Effects of Cholinergic Drugs on Ureteral Function in Anesthetized Dogs

Abstract

Our results demonstrate that in anesthetized dogs cholinergic receptor stimulation has a suppressive effect on ureteral pressure and peristalsis in obstructed ureters, in contrast to its activation of bladder smooth muscle.

Autonomic and sensory nerve modulation of peristalsis in the upper urinary tract

“…Carbachol also decreases ureteric pressure and peristalsis in partially or completely obstructed ureters of anaesthetised dogs in a manner unaffected by muscarinic antagonists (Tomiyama et al, 2004).…”

First Prize: Pharmacologic Manipulation of the Porcine Ureter: Acute Impact of Topical Drugs on Ureteral Diameter and Peristaltic Activity

“…Studies to evaluate ureteral peristalsis have largely used endoluminal methods, employing either a pressure transducer [1][2][3][4] or an ultrasound probe 5 to evaluate ureteral physiology. However, these endoluminal devices can themselves alter ureteral peristalsis, and, hence, intraluminal evaluation technologies cannot be applied to measure ureteral peristalsis and the ureter's response to interventions such as stenting accurately.…”

Physiology and Pharmacology of the Human Ureter: Basis for Current and Future Treatments

“…However, Roshani et al [24] demonstrated that smooth muscle motor activity in the mid and the distal ureter was not modulated by muscarinic receptors in the porcine model. In another study, cholinergic receptor stimulation by muscarinic agonist carbachol in anesthetized dogs had a suppressive effect on ureteral pressure and peristalsis in obstructed ureters [25] . Tomiyama et al [26] suggested that carbachol-induced contraction in the isolated canine ureter was mediated through the M 3 -receptor.…”