2013
DOI: 10.1016/j.ejphar.2013.02.009
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Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats

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Cited by 12 publications
(7 citation statements)
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“…Acetylcholine is the primary neurotransmitter for parasympathetic nerves to exert their protective effect, and it is degraded by AchE, which binds to its nicotinic and muscarinic receptors (37). According to our result, DON significantly repressed the AchE activity in both plasma and lung tissue of MCT rats, suggesting that intraperitoneal injection 1 mg/kg DON effectively corrected the downregulation of parasympathetic activity in PAH, whose dosage function has been evidenced in previous studies (22,23,38,39). We also showed that DON treatment obviously reduced α-7nAchR expression in the lung tissue of PAH rats.…”
Section: Discussionsupporting
confidence: 83%
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“…Acetylcholine is the primary neurotransmitter for parasympathetic nerves to exert their protective effect, and it is degraded by AchE, which binds to its nicotinic and muscarinic receptors (37). According to our result, DON significantly repressed the AchE activity in both plasma and lung tissue of MCT rats, suggesting that intraperitoneal injection 1 mg/kg DON effectively corrected the downregulation of parasympathetic activity in PAH, whose dosage function has been evidenced in previous studies (22,23,38,39). We also showed that DON treatment obviously reduced α-7nAchR expression in the lung tissue of PAH rats.…”
Section: Discussionsupporting
confidence: 83%
“…Rats in control group were given equal volume of saline by intraperitoneal injection. MCT-induced PAH rats were intraperitoneal injected with DON (1 mg/kg, Selleck, USA) daily after 1-week delivery of MCT to the end of the fourth week (22,23). All animal care and experiments were approved by the Animal Research Committee of Central South University in Hunan, China.…”
Section: Animalsmentioning
confidence: 99%
“…We have previously demonstrated the efficacy of morphine on breathing and analgesia in anesthetized rats [18], where morphine (1.0 and 3.0 mg/kg, i.v.) suppressed V E and prolonged the paw withdrawal latency in a dose-dependent manner.…”
Section: Experiments 1: Effects Of Rolipram and Caffeine On Morphine-imentioning
confidence: 99%
“…The method was similar to that reported previously [18]. Male Wistar rats (6-7 weeks, 120-200 g) were anesthetized intraperitoneally with urethane (1.1-1.3 g/kg) and placed on a cloth holder in the prone position.…”
Section: Experiments 1: Simultaneous Measurements Of Spontaneous Ventimentioning
confidence: 99%
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