Effects of Chronic Caffeine Alimentation on the Performance Indicators of Rat Neocortex Background Electrical Activity

Turitskaya, T. G.; LUKASHEV, S.; Lyashenko, V. P.

doi:10.25040/ecpb2016.03.011

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…An analysis of electrohypothalamograms showed that in the trophotropic zone of the hypothalamus, after two weeks of caffeine alimentation, an increase in the absolute and normalized power of the main deltarhythm was observed. Our previous studies (Turic'ka et al, 2015(Turic'ka et al, , 2016 showed that this growth is much smaller than in the neocortex and hippocampus under similar conditions, but is clearly indicative of the activation of mediator synthetic systems. The most specific for this focus of the rat brain is the significant inhibition of both the power and the representation of high-frequency rhythms of the electrohypothalamogram after 4-8 weeks of the experiment.…”

Section: Discussionmentioning

confidence: 73%

The features of summary background electric activity of the hypothalamus of rats under conditions of chronic caffeine alimentation

Turitskaya

LUKASHEV

Lyashenko

et al. 2018

Regul. Mech. Biosyst.

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One of the factors of the environment which essentially shifts homeostasis is diets which contain caffeine. The aim of the study was to find out the basic characteristics of background electrical activity of trophotrophic and ergotrophic zones of the hypothalamus in conditions of chronic caffeine alimentation. Experiments were carried out on non-linear white male rats. The first group consisted of control animals (n = 22). The second group (n = 24) was represented by the animals that were given pure caffeine in an amount of 150 mg/kg/day with their meal. The registration on a electrohypothalamogram was carried out in conditions of acute experiment, every 2 weeks for 12 weeks. The spectral (mkV2) and the normalized power (%) of electrohypothalamogram waves were analyzed within the common frequency band. The analysis of the results allowed us to establish a certain specificity of the reaction of the neuronal system of the trophotropic and ergotropic zones of the rat hypothalamus to the effect of chronic caffeine alimentation. The main difference in the reactive state of electrophysiological indices in the trophotrophic zone of rats is the lack of a typical desynchronization from the 4th to the 8th week of the study and the hypersynchronization after 12 weeks of the experiment. The most probable mechanism that explains the results obtained is the ultra-powerful GABA-ergic modulation of this zone, the main energy-accumulating center. Perhaps, this powerful inhibitory resource in this cerebral locus is the main stress-limiting factor that makes this zone of the central nervous system of rats less sensitive to caffeine exposure. Instead, under the influence of chronic caffeine load in the ergotropic zone of the hypothalamus, after 6 weeks of the experiment desynchronous high-frequency rhythms dominated. During the subsequent time of the experiment, we observed a decrease in both low-frequency and high-frequency components of the electrohypothalamogram of this zone. This gives reason to assume that the key component of the neurophysiological response of the posterior hypothalamus of rats to the caffeine ration is the powerful glutamatergic effects on the pre-synaptic and post-synaptic neurons under conditions of reactive exhaustion of local neurosynthetics. Caffeine depletion of the hypothalamic neurotransmission at the end of the experiment is replaced by an effective adaptive ergotropic restoration of neurosynthetic activity in this locus of the central nervous system of rats. Thus, caffeine has a powerful activating effect on the ergotropic function of the posterior hypothalamus of rats. Such a difference in the chronic effect of caffeine on the trophotropic and ergotropic zone of the rat hypothalamus is primarily due to the different mediator support of these zones underlying their physiological purpose. GABA is the main mediator of the trophotropic zone and the main neurotransmitter of its synchronous activity. At the same time, neurotransmitter support of the ergotropic zone is represented by glutamate, which, along with other agents, implements its desynchronous activity. Since caffeine stimulates excitation, activating the pathways traditionally associated with motivational and motor reactions in the brain, it can be assumed that this explains the fact of a more powerful influence of caffeine precisely on the ergotrophic zone of the hypothalamus.

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Section: Discussionmentioning

confidence: 73%

The features of summary background electric activity of the hypothalamus of rats under conditions of chronic caffeine alimentation

Turitskaya

LUKASHEV

Lyashenko

et al. 2018

Regul. Mech. Biosyst.

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“…Some authors showed (Murzin et al, 2015;Berchenko et al, 2016) that delta-activity and rhythm synchronization are prevalent in on electrocorticograms of juvenile and young rats. According to some studies (Chaus et al, 2008;Turic'ka et al, 2016), indicators of the power of the delta-rhythm of bioelectric activity of the cerebral cortex of control animals in percentages fluctuated within 73.2-87.6%. Also, works of these authors indicate a decrease in the absolute power of bioelectric activity in all rhythms starting at 7 months, which is similar to our results.…”

Section: Discussionmentioning

confidence: 99%

The bioelectric type of the visual area of the cerebral cortex of rats of all ages and sexes

Мизин

Lyashenko

Lukashov

2018

Regul. Mech. Biosyst.

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In the ontogenesis process, the cerebral cortex undergoes age-related changes. So far as, unlike practically all other systems of mammalian organs, the brain continues to develop and receive new functionality in the postnatal period. Thus with age, there are changes in the bioelectric characteristics of the neocortex. The purpose of the research is to determine the age and sex changes in the bioelectric activity of the cerebral visual cortex of male and female rats of different ages. In the article, we examined changes in absolute (μV2) and normalized (%) indicators of electrical activity of the visual area of rats of different sexes in four age groups: juvenile, young, mature, and presenile age. The research was carried out by the method of registration of bioelectric activity of electrocorticograms (ECoG). Results of multifactorial dispersion analysis of absolute and normalized ECoG indicators of the visual area of the cerebral cortex of rats of all ages showed that there were reliable changes in the frequency-amplitude characteristics of bioelectric activity related to age. At a young age, males have probably lower absolute and normalized power of the delta-rhythm and the normalized beta-like rhythm rate. There was a tendency of decrease in the theta-rhythm. As a result of this redistribution of rhythms a desynchronization of the electrical activity of young males was observed. Mature males have lower absolute power indicators than younger age groups. According to normalized indicators, a synchronization of rhythms of males in the mature age group was observed, which together with values of absolute power can indicate a decrease of the functional activity level of the neocortex and an increase of the influence of endogenous mechanisms on neuronal activity of the visual area of the cerebral cortex. In the presenile age, there was a desynchronization of rhythms. The indicators of an absolute and normalized power of females in the young age group pointed to the synchronization of the bioecoactivity of the neocortex. Among the low-frequency waves, theta-rhythm rhythm dominated in the females of young age. In the mature and presenile age females, there was a probable increase in the percentage of normalized parameters of high-frequency beta waves. The predominance of this rhythm may indicate an increase of cortical tone. The correlation of values of absolute and normalized indicators of bioelectric activity affirmed the desynchronization of the ECoG rhythms of females of mature and presenile age. Sex differences are expressed by a decrease in the absolute power of all ECoG rhythms of the visual area of the cerebral cortex of females relative to males. The age-related changes occurred in a different way in rats of different sex. At a young age, males had desynchronization of rhythms, and females had synchronization, in the mature age it was vice versa. The age changes of the electric activity of the cerebral visual cortex of rats in our opinion may be largely associated with involutional changes of various neurotransmitter and hormonal systems.

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Effects of Chronic Caffeine Alimentation on the Performance Indicators of Rat Neocortex Background Electrical Activity

Cited by 2 publications

References 7 publications

The features of summary background electric activity of the hypothalamus of rats under conditions of chronic caffeine alimentation

The features of summary background electric activity of the hypothalamus of rats under conditions of chronic caffeine alimentation

The bioelectric type of the visual area of the cerebral cortex of rats of all ages and sexes

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