Effects of chronic chagasic infection on the number and size of cardiac neurons of the wild rodent Calomys callosus

De-Souza, Romeu Rodrigues; Vasconcelos, D C De; Maifrino, Laura Beatriz Mesiano; Liberti, Édson Aparecido

doi:10.1590/s0074-02761999000500020

Cited by 3 publications

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“…The savannah environment in the middle eastern part of Brazil is one of its main natural habitats. Calomys callosus have been described as an alternative for the construction of experimental models of trypanosomiasis, toxoplasmosis and schistosomosis (Andrade et al 1994;De-Oliveira et al 1997;Favoreto-Junior et al 1998;De-Souza et al 1999).…”

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Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Berbert

Faria

Gennari-Cardoso

et al. 2006

Int J Experimental Path

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The responses of animal experimental models related to the infectivity, virulence and pathogenicity of Paracoccidioides brasiliensis is constantly used to develop new perspectives of investigation. The rodent Calomys callosus, Rengger 1830 (Rodentia: Cricetidae) is an indigenous inhabitant of the savannah environment found in the central regions of Brazil. The aim of the present work was to evaluate the histopathological and serological features of C. callosus after inoculation with the Pb18 strain of P. brasiliensis. Furthermore, A/Sn and B10.A mice strains were also tested to compare the results obtained in C. callosus to these well-established experimental models of resistance and susceptibility respectively. In every instance, survival analysis was performed, and histopathological study of the lungs, liver and spleen was employed to investigate tissue involvement, degree of inflammation and fungal presence. Levels of antibodies to P. brasiliensis were measured by using an enzyme-linked immunosorbent assay after 4 weeks and at the advanced stage of infection. The mortality rate was proportional to inoculation dose in all groups, but overall it was much superior in C. callosus than in the B10.A-susceptible mice. Macroscopical and microscopical pathological alterations were also more extensive and remarkable for C. callosus, once again proportional to inoculation dose, but more noticeable differences among the studied groups were found with 0.6x10(5) inoculum. In addition, the serological profile of C. callosus was similar to that found for B10.A-susceptible mice. Infection of C. callosus with 0.6x10(8) Pb18 inoculum resulted in more serious illness, and it decreased in severity in proportion to the inoculum dose. This difference was more pronounced in C. callosus, and the clinical, serological and pathological findings in this animal were more intense and precocious compared with the B10.A-susceptible mice. The present results suggest that C. callosus is a potentially alternative experimental animal model for paracoccidioidomycosis infection.

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confidence: 99%

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Berbert

Faria

Gennari-Cardoso

et al. 2006

Int J Experimental Path

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“…In a range of studies the neuron number and sizes have appeared as significant indexes displaying the age-related alterations in the intrinsic neurons of the trachea [3], small intestine [9,12] and heart [1]. Furthermore, counting of neurons and determination of neuron sizes have played an important role in studies that were aimed to analise the effects of pre-natal undernutrition on the rat intestines [2,25] as well as the effect of the Chagasic infection on the rat heart [ (7].…”

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Training alters cardiac neuron sizes in Wistar rats

Souza¹,

Gama²,

Santarém³

et al. 2009

Biol Sport

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Abstract. The action of the parasympathetic nerves on the heart is made through a group of neurons located on the surface of the atria. This study evaluated the effect of a chronic training protocol on the number and sizes of the cardiac neurons of Wistar rats. Whole mount preparations of the atria of 12-month old male sedentary and trained rats (40 weeks of running on a treadmill 3 times a week, 16 m/min) were assessed for number and size (maximal cellular profile area) of the cardiac neurons. The cardiac neurons were ascertained by using the NADH-diaphorase technique that stains the cell bodies of the neurons in dark blue. The number of cardiac neurons in the trained rats (P>0.05) did not change significantly. In the sedentary group there were small, medium sized and large neurons. However there was a notable increase in the percentage of small neurons in the rats submitted to the training compared to the sedentary group (P<0.05). Previous studies have shown that electrophysiologically, the small neurons are more easily excitable than the large neurons. It is possible that the results of the present work reflect an adaptation mechanism of the cardiac neurons presumably with the objective of increasing the excitability of the neurons for the vagal action and resulting facilitation of the sinusal bradycardia observed at rest and in the exercise. We concluded that the training affects significantly the size of the cardiac neurons in Wistar rats.

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Comparative quantitative study of the intrinsic cardiac ganglia and neurons in the rat, guinea pig, dog and human as revealed by histochemical staining for acetylcholinesterase

Pauža¹,

Paužienė²,

Pakeltyte³

et al. 2002

Annals of Anatomy - Anatomischer Anzeiger

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Effects of chronic chagasic infection on the number and size of cardiac neurons of the wild rodent Calomys callosus

Cited by 3 publications

References 0 publications

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Training alters cardiac neuron sizes in Wistar rats

Comparative quantitative study of the intrinsic cardiac ganglia and neurons in the rat, guinea pig, dog and human as revealed by histochemical staining for acetylcholinesterase

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