Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Mansy, Wael; Alogaiel, Deema M; Hanafi, Mona; Zakaria, Enas

doi:10.4314/tjpr.v16i12.8

Cited by 18 publications

(25 citation statements)

References 15 publications

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“…Another possible explanation for the alteration in these parameters is the ureainduced activation of xanthine oxidase, which accelerates the rate of uric acid biosynthesis from xanthine (Obochi et al, 2010). In contrast to previous studies that reported a significant increase in serum creatinine levels, no significant changes were detected in the current study which can be explained by the shorter experimentation period in this study compared to the previous reports (Mansy et al, 2017). Peroxide free radicals are excessively produced as a result of the oxidative stress induced by the persistent hyperglycemia, eliciting renal oxidative damage in the form of interstitial inflammation, increased proteinuria and histopathological changes of the renal tissue (Gheith, 2017).…”

Section: Discussioncontrasting

confidence: 99%

“…It is to be noted that both heart and liver tissues did not show pathological changes despite the biochemical changes observed in the animals' lipid profile. This can possibly be assigned to the relatively short duration of the current experiment in comparison to the other studies that showed changes in the liver tissue after 12 weeks of ED administration (Mansy et al, 2017).…”

Section: Discussionmentioning

confidence: 80%

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The metabolic disorders associated with chronic consumption of soft and energy drinks in rats*

Eltahir

Alamri

et al. 2020

Acta Biochim Pol

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Background: Energy Drinks (EDs) and Soft Drinks (SDs) are widely consumed among adolescents and young adults. These drinks contain variable amounts of caffeine which is a central nervous system stimulator; in addition to sugar, taurine, vitamins and herbal extracts. Several adverse effects have been reported for the excessive consumption of caffeine and sugar. Aim: This work aimed at providing a comparison between the effect of chronic consumption of both drinks on metabolism biochemically as well as at the histopathological level. Methods: Adult albino rats were randomly divided into three groups and treated for 4 weeks. Animals received water (control, group 1), 12.5 ml/kg/day of either Pepsi ® (SD, group 2) or Power Horse ® (ED, group 3). All animals had free access to water and standard animal chow. Results: ED and SD groups showed a significant weight gain compared to control. ED animals showed a significant increase in serum urea, hyperlipidemia and hyperglycemia in comparison to control and SD groups. Serum uric acid significantly increased in ED and SD groups. ED group showed congestion and inflammation in their renal tissues in addition to splenomegaly and increased phagocyte infiltration. Conclusion: The high caffeinesugar content in ED exerts a more significant influence on the metabolic pathways than SDs. Both increase the incidence of cardiovascular diseases and tissue inflammation due to their effect on lipid profile and blood glucose. The other ingredients in EDs may play a role in the observed metabolic disturbances. Chronic use of EDs should be especially discouraged to avoid these negative effects.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 80%

The metabolic disorders associated with chronic consumption of soft and energy drinks in rats*

Eltahir

Alamri

et al. 2020

Acta Biochim Pol

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“…These results were in agreement with Reis et al [27] and Mansy et al [28] . Seifert et al [2] found that these effects may be caused by the mixture of various ingredients in the ED due to synergistic interaction and augmented oxidative effect of them.…”

Section: Discussionsupporting

confidence: 93%

“…Also, Attia and Nasr [38] found that the suppression of AChE resulted in the cumulation of acetylcholine (ACh), that may cause lymphocytes stimulation and elevated cellular cyclic guanosine monophosphate concentration, increased lymphocyte motility and cytotoxicity. Mansy et al [28] explained the congestion of blood vessels by microcirculatory disturbance that caused by energy drink intake. Also, Kassab and Tawfik, [41] mentioned that ED had been associated with many cardiovascular disorders as well as increased platelet aggregation and impaired endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Study of the biochemical, histological and cytogenetic effects of two different energy drinks (EDs); Red bull and power horse; on brain of adult male Albino rats and to determine the possible protective role of omega-3 on the adverse effects of EDs".

El-Sayed

Afify

Abdelwahab

et al. 2020

Journal of Recent Advances in Medicine

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Background: Energy drinks (EDs) became a worldwide phenomenon and popular especially among young adult and the brain is one of the most vulnerable organs to toxicity. Objective: This work aimed to study the sub chronic effect of consumption of two different popular energy drinks (power horse and red bull) on the brain of adult male albino rats through biochemical, histological and cytogenetic parameters, and to determine the possible protective role of Omega-3 on the adverse effects of EDs. Also, to determine the effects of EDs withdrawal (recovery period). Methodology: Forty-eight adult male albino rats were divided into 8 groups; control, omega 3, RB, PH, each of EDs combined with omega 3 and after 2 weeks of withdrawal. Blood samples, brains and femora from the rats were obtained for biochemical, histological and cytogenetic evaluation. Results: The studied EDs resulted in elevation of the oxidative stress marker malondialdehyde, structural and numerical chromosomal aberrations. While they decreased the antioxidant markers (catalase and Superoxide dismutase), acetylcholinesterase activity, total content of DNA and RNA in brain tissue and the mitotic index with disturbance in the normal histology of the brain. Either treatment with omega 3 or EDs withdrawal improve these changes with better effect to omega 3. Conclusion: EDs are toxic to the brain. Omega 3 or EDs withdrawal can ameliorate this toxicity with better effect to omega 3. Therefore, strict control of EDs consumption is urgently needed.

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“…In the present study, in RB treated group there were a decrease in SOD and GSH levels in the pancreatic tissue. This result was in accordance with that of Mansy et al [19] who gave two oral doses of energy drink (1.1 and 2.2 ml/100g body weight/day) for 12 weeks and reported a significant decrease in SOD. Also, Al-Eryani et al [20] reported a significant decrease in GSH in homogenized testes after administration of Red Bull and Power Horse for 7 weeks.…”

Section: Energy Drinksupporting

confidence: 92%

The Toxic Effect of Energy Drinks on The Structure of Pancreas of Adult Male Albino Rats

Hulail¹,

Qenawy²,

Abdel-Kareem³

et al. 2019

Zagazig University Medical Journal

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Background: A controversy developed between the benefits of energy drinks versus the possible health threats since its revolution. Lack of information was a call to assess the effect of chronic consumption of Red Bull (RB) as one of the energy drinks, on the structure of the pancreas. The Aim of this Work is to evaluate the effect of Energy drinks (Red Bull) on rat pancreas and ability of rat pancreas to recover from effects of Red Bull. Methods: Thirty adult male albino rats divided into three groups, control, treated and recovered. Treated group was received 7.5 ml of RB by oral gavage daily for 4weeks. Recovered group was left to recover for 15 days without any additional treatment. The rats will be anaesthetized and sacrificed. Pancreas prepared for light microscopic examination and tissue homogenate. Results: Red Bull (RB) induced pancreatic injury in the rats evidenced by histopathological alterations like, distorted pancreatic acini with vacuolated cytoplasm and vacuolated islets of Langerhans. Furthermore, RB administration caused oxidative damage by decreasing in reduced glutathione (GSH) and superoxide dismutase (SOD) levels in the pancreatic tissue. Stoppage of RB exposure resulted in amelioration in the histological alterations as compared with the RB treated rats. Conclusion: RB produces degenerative changes in the pancreas and causes oxidative stress. Stoppage of RB exposure results in some restoration of the normal histological structure of the pancreas. So, it is recommended to stop the usage of RB.

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Effects of chronic consumption of energy drinks on liver and kidney of experimental rats

Abstract: Purpose: To investigate the effects of chronic intake of a brand of energy drink (ED) on

Cited by 18 publications

References 15 publications

The metabolic disorders associated with chronic consumption of soft and energy drinks in rats*

The metabolic disorders associated with chronic consumption of soft and energy drinks in rats*

Study of the biochemical, histological and cytogenetic effects of two different energy drinks (EDs); Red bull and power horse; on brain of adult male Albino rats and to determine the possible protective role of omega-3 on the adverse effects of EDs".

The Toxic Effect of Energy Drinks on The Structure of Pancreas of Adult Male Albino Rats

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