Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats

Dremencov, Eliyahu; Grinchii, Daniil; Romanova, Zuzana; Chomanic, Pavol; Lacinová, Ľubica; Ježová, Daniela

doi:10.1007/s43440-023-00485-1

Cited by 4 publications

(7 citation statements)

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“…In male offspring of dams treated with SNC80, the firing rate and the percentage of spikes in bursts were lower compared to corresponding values in control offspring. Chronic treatment with the same delta-opioid agonist during adulthood in our previous study ( Dremencov et al, 2023 ) led to an opposite effect, namely, increased firing rate of glutamate and dopamine neurons in male rats. In the mentioned study, the SNC80 effects in female rats were however not investigated.…”

Section: Discussionmentioning

confidence: 69%

“…It was also shown that the activation of delta-opioid receptors in adult rats experienced hypoxia improve spatial cognition, and hippocampal neurogenesis and synaptic transmission ( Wang et al, 2016 ; Zhang et al, 2021 ). Treatment of adult rats with delta-opioid agonists appears to induce mild anxiolytic effects ( Saitoh et al, 2004 ; Dremencov et al, 2023 ). However, as shown in the present study, such effects were not transferred to the offspring.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo electrophysiological experiments described previously ( Dremencov et al, 2022 ; Grinchii et al, 2022 ; Dremencov et al, 2023 ; Grinchii et al, 2023 ) were performed in male and female adult offspring of the SNC80- and vehicle-treated dams 24 h following behavioral testing. Urethane (1.25 g/kg, intraperitoneally: i. p.) or chloral hydrate (0.4 g/kg, i. p) anesthesia was used in experiments aiming to assess the excitability of hippocampal glutamate and brainstem monoamine neurons, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Linear regression was used to evaluate the habituation course of locomotor activity. The individual rate of habituation (k-value) expresses the rapidity of habituation (Dubovicky et al, 1999;Dubovicky and Jezova 2004;Dremencov et al, 2023).…”

Section: The Open Field (Of) Testsmentioning

confidence: 99%

“…We have shown in rats that chronic treatment with the delta-opioid agonist SNC80 induced mild anxiolytic effects and increased locomotion. The behavioural changes were accompanied by alterations in central neurotransmission as revealed by in vivo electrophysiology ( Dremencov et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Maternal treatment with a selective delta-opioid receptor agonist during gestation has a sex-specific pro-cognitive action in offspring: mechanisms involved

Dremencov,

Oravcova,

Grinchii

et al. 2024

Front. Pharmacol.

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Background: There is growing evidence that the treatment of several mental disorders can potentially benefit from activation of delta-opioid receptors. In the future, delta-agonists with a safe pharmacological profile can be used for the treatment of mood disorders in pregnant women. However, the data on prenatal exposure to delta-opioid agonists are missing. The present study is aimed to test the hypothesis that the activation of delta-opioid receptors during gravidity has positive effects on the behaviour accompanied by changes in glutamate and monoamine neurotransmission.Methods: Gestating Wistar rats were chronically treated with a selective delta-agonist SNC80 or vehicle. Adult male and female offspring underwent novel object recognition (for the assessment of cognition) and open field (for the assessment of anxiety and habituation) tests, followed by in vivo electrophysiological examination of the activity of hippocampal glutamate and midbrain serotonin (5-HT) and dopamine neurons.Results: We found that the maternal treatment with SNC80 did not affect the offspring’s anxiety, habituation, and 5-HT neuronal firing activity. Female offspring of SNC80-treated dams exhibited improved novelty recognition associated with decreased firing rate and burst activity of glutamate and dopamine neurons.Conclusion: Maternal treatment with delta-opioid agonists during gestation may have a pro-cognitive effect on offspring without any negative effects on anxiety and habituation. The putative pro-cognitive effect might be mediated via mechanism(s) involving the firing activity of hippocampal glutamate and mesolimbic dopamine neurons.

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Section: Discussionmentioning

confidence: 69%