Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Dixit, Devarshi; Singh, Sanjeev K.; Tiwari, Anil Kumar; Mandal, Maloy B

doi:10.5455/njppp.2017.7.0518906062017

Cited by 8 publications

(7 citation statements)

References 17 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, animals given the low and high oral doses of BPS exhibited the same gastric changes as those reported by Dixit et al 20 These researchers found that BPS inhibited Ach‐induced contractions of the intestine and stomach. Further, Sharma and Madal 21 demonstrated the same previous finding by exposure to cumulative bath concentrations of BPA (0.1–100 μM) and BPS (0.1–100 μM), and this coincides with reduced serum gastrin levels in rats exposed to BPS in our study, with the long contact time between BPS and the gastric wall explaining the gastric changes.…”

Section: Discussionsupporting

confidence: 87%

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Khalifa

Hosny

Matter

et al. 2022

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Bisphenol S (BPS) is used as an alternative to bisphenol A (BPA) in polycarbonate plastics, epoxy resins and thermal receipt sheet manufacturing. We examined the toxic effects of BPS on gastric and renal functions, as well as the efficacy of allopurinol as a treatment. Albino rats were given only BPS (30 and 120 mg/kg BW/day), and some were treated with allopurinol prior to sacrifice. Gastric and renal specimens were evaluated histologically and immunohistochemically, and blood from the tail vein was analysed for levels of gastrin, uric acid (UA), erythropoietin and 8‐deoxyguanosine (8‐OHdG). Gastrin levels decreased while erythropoietin, UA and 8‐OHdG levels increased significantly. The severity of gastric and renal damage observed in BPS‐treated animals increased with increasing doses. The mean percentage of COX‐2 immunoreactivity and the mean number of CD45 immunoreactive cells were significantly increased in the stomach and kidney of BPS rats. Allopurinol ameliorated the biochemical, histological and immunohistochemical alterations induced by BPS, with superior protection at lower doses. Allopurinol can reverse the effects of BPS on the stomach and kidneys.

show abstract

Section: Discussionsupporting

confidence: 87%

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Khalifa

Hosny

Matter

et al. 2022

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…The relaxative effect of BPA was also observed in studies using smooth muscle collected from other tissues. It was shown that BPA inhibited the contractile activity of the duodenum ( 37 ) and the distal ileum and mid colon in rats ( 8 ). This means that regardless of the origin of the smooth muscle origin it acts upon, BPA always has a relaxative effect.…”

Section: Discussionmentioning

confidence: 99%

Effects of bisphenol A and bisphenol F on porcine uterus contractility

Zygmuntowicz

Markiewicz

Grabowski

et al. 2022

Journal of Veterinary Research

View full text Add to dashboard Cite

Introduction Bisphenols, as endocrine disruptors, may cause a wide range of health problems in humans, but so far, not all of them have been confirmed in animals, including pigs. Since animals are also exposed to bisphenols, we hypothesised that these substances may have an effect on uterine contractility in pigs. Therefore, the aim of the study was to investigate the effect of the most-used bisphenol, bisphenol A (BPA), and a selected analogue, bisphenol F (BPF), on the contractile activity of the pig uterus. Material and Methods The investigation utilised smooth muscles from immature pigs (n = 6), cyclic pigs on days 12–14 of the oestrous cycle (n = 6) or early pregnant pigs on days 12–16 of pregnancy (n = 6). Strips of the myometrium were exposed to BPA and BPF at concentrations of 10−13–10−1 M. Smooth muscle contractility was determined with equipment for measuring isometric contractions. Results BPA caused a significant decrease in contraction amplitude, and frequency and in myometrial tension in all groups examined. BPF caused a decrease in the amplitude and frequency of contractions in all groups and in myometrial tension in the early pregnant group. Conclusion The obtained results indicate that both BPA and BPF relaxed the porcine myometrium, but these changes, especially in the amplitude and frequency of contractions, were more evident after BPF treatment. The extent of relaxation is dependent on the physiological status of the animals.

show abstract

“…Recently, chronic ingestion high-concentration BPA (25 times the concentration used in the present study) decreased rat ileal contractions. [10] On reproductive system, BPA exerts toxic effect on uterine endometrial proliferation, uterine receptivity associated with implantation failure in animals. [6] In human beings, BPA exposure is associated with adverse birth outcome, sexual dysfunction, and impaired implantation.…”

Section: Discussionmentioning

confidence: 99%

Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro

Gupta¹,

Deshpande²

2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

Background: Bisphenol A (BPA), a chemical used in the manufacture of plastics, has toxic effects on reproductive, developmental, and metabolic systems. It is implicated as a causative factor for infertility. The uterine and tubal contractility play a vital role in fertilization and implantation of zygote. The chronic exposure to BPA on myometrial contractions is not known. Aims and Objectives: The aim of this study is to examine the effect of chronic ingestion of BPA on rat uterine contractions evoked by acetylcholine. Materials and Methods: Rats weighing 90-150 g were fed BPA (2 µg/kg/day) or placebo containing pellets (time-matched control; TMC) orally for 28 days. The contractility of the uterus was also assessed in group of rats at the beginning (initial control [IC]). After 28 days, animals showing estrous phase were chosen for in vitro recording of uterine contractions (35 ± 1°C). Evoked contractions to different concentrations of acetylcholine were recorded followed by the effect on spontaneous contractions. Results: Acetylcholine evoked uterine contractions in vitro in a concentration-dependent manner. The contractions were similar in magnitude in IC and TMC. The uterus from BPA-fed animal exhibited decreased responsiveness to acetylcholine-evoked contractions as compared to TMC. In the presence of acetylcholine, frequency and force of spontaneous contractions increased in a concentration-dependent manner. However, in BPA-fed group, the frequency and force of spontaneous contractions were significantly attenuated. Conclusions:The results indicate that chronic exposure to BPA decreased the acetylcholine-evoked contractions as well as the spontaneous uterine contractions. The decreased contractility may account for the infertility seen after exposure to BPA.

show abstract

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Cited by 8 publications

References 17 publications

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Effects of bisphenol A and bisphenol F on porcine uterus contractility

Chronic ingestion of bisphenol A decreases the cholinergically evoked and spontaneous contractions of rat uterus in vitro

Contact Info

Product

Resources

About