Effects of chronic irisin treatment on brain monoamine levels in the hypothalamic and subcortical nuclei of adult male and female rats: An HPLC-ECD study

Yardımcı, Ahmet; Ertugrul, Nazife Ulker; Ozgen, Aslisah; Ozbeg, Gulendam; Ozdede, Mehmet Ridvan; Ercan, Eda Coban; Canpolat, Sinan

doi:10.1016/j.neulet.2023.137245

Cited by 8 publications

(1 citation statement)

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“…The sex-dependent behavioral differences are due to the differential activities of various brain regions and their associated neurotransmitter systems [38,39], which can also be affected by environmental stress. For example, stress is reported to increase dopamine and serotonin concentrations in subcortical regions controlling social behavior in females, while increasing the metabolites of these neurotransmitters in males [15,41]. Similarly, the expression of mAChRs in the ventral hippocampus is reported to increase due to stress in male mice only [42].…”

Section: Discussionmentioning

confidence: 99%

Sexually Dimorphic Effects of Neuromodulatory Drugs on Normal and Stress-Induced Social Interaction in Rats

Ishaq,

Ahmed

2023

Brain Sciences

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Social behavior is a complex term which involves different interactions between various individuals of a community. It is controlled by different neurotransmitter systems in a sexually dimorphic way. Certain environmental factors, like stress, cause various neurological disorders with associated social abnormalities in a sexually dimorphic way. Multiple drugs are used in clinical settings to treat behavioral disorders. However, the sexually dimorphic effects of these drugs, particularly on social behavior, still need to be studied. The present study was designed to investigate the sex-dependent effects of Risperidone, Donepezil, and Paroxetine in 8–12 weeks old male and female rats under normal and stressed conditions. There were four male and four female groups, i.e., control group (no drug treatment), Risperidone (3 mg/kg/day) treated group, Donepezil (5 mg/kg/day) treated group, and Paroxetine (10 mg/kg/day) treated group. Each group received its respective drug during phase 1 for 21 days, followed by a 10-day break with no drug treatment. After the break, same groups received the same drugs along with tilt-cage stress for an additional 21 days during phase 2. A social preference and novelty test was performed at the end of both phases (1 and 2). During phase 1, Risperidone treatment caused impaired social behavior and reduced locomotion in the male group only, compared to its control group. Donepezil treatment caused a reduction in social interaction, while Paroxetine treatment caused increased social interaction and locomotion in a sex-dependent manner. During phase 2, social novelty was affected in both male and female stress groups. Treatment with drugs along with stress showed differential sex-dependent effects. The study showed a predominant effect of Risperidone on males while there were differential effects of Donepezil and Paroxetine on both sexes. This study has paved the way for the development of more targeted and effective neuromodulatory drugs for use against various psychiatric and social deficits.

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