Effects of Chronic Occupational Exposure to Measured Concentrations of Benzene

Fishbeck, William A.; Townsend, J.C.; Swank, Marlene G.

doi:10.1097/00043764-197808000-00005

Cited by 28 publications

(19 citation statements)

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“…Many authors have shown that routine blood tests are not sensitive enough to detect early changes due to the toxic effects of benzene (17,28,31,(35)(36)(37)(38). According to the finding of this study, exposure to benzene concentrations below 1 ppm was reported in painters, causing few changes in blood cells, besides hematological changes associated with exposure to higher concentrations of benzene.…”

Section: Discussionmentioning

confidence: 56%

“…Reduction in complete blood cell (CBC) count to levels below the normal limit is termed as pancytopenia, leading to aplastic anemia (16). Some authors have proposed hemoglobin (17,18), mean corpuscular volume (MCV) (19,20), absolute lymphocyte count (21)(22)(23), and CBC count (24)(25)(26) as appropriate tests for the detection of toxic effects.…”

Section: Introductionmentioning

confidence: 99%

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Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

et al. 2017

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Background: Exposure to benzene causes several adverse effects, including decreased number of erythrocytes, leucocytes, and red blood cells, and results in aplastic anemia. The aim of this study was to investigate hematological changes due to benzene exposure in painting workers. Methods: This study was conducted on benzene-exposed and nonexposed workers in Tehran, Iran. The study sample included 40 painters exposed to different levels of benzene and 40 unexposed controls in an automobile manufacturing company. Sampling was carried out with an active pump sampler, using the NIOSH method 1501. Varian C-3800 gas chromatography-flame ionization detector (GC-FID) was used for the analysis of 40 benzene samples. Blood samples from 80 workers were collected from both the case and control groups. Hematological indices were analyzed for red blood cell, white blood cell, hematocrit, hemoglobin, platelet, and white cell differential count.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

et al. 2017

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“…Benzene is widely used in the petroleum industry, and known a myelotoxic effect in human (Ert & Rhoads 1939, Thorpe 1974, Fishbeck et al 1978, Kipen et al 1989). Occupational exposure to benzene could decrease the levels of hemoglobin, white cell counts, absolute lymphocyte counts, and red cell counts, mean corpuscular volume, and platelets, as well as increase a risk of leukemia (Fishbeck et al 1978, Kipen et al 1989, Ward et al 1996, Khuder et al 1999, Duarte-Davidson et al 2001, Costantini et al 2003, Rothman et al 1996.…”

Section: Introductionmentioning

confidence: 99%

“…Occupational exposure to benzene could decrease the levels of hemoglobin, white cell counts, absolute lymphocyte counts, and red cell counts, mean corpuscular volume, and platelets, as well as increase a risk of leukemia (Fishbeck et al 1978, Kipen et al 1989, Ward et al 1996, Khuder et al 1999, Duarte-Davidson et al 2001, Costantini et al 2003, Rothman et al 1996. However, some studies suggested that benzene exposure could increase the red blood cell mean corpuscular volume (Fishbeck et al 1978, Rothman et al 1996. The demand of benzene in Taiwan occupies at least 2 % (560*106 ton) over the world.…”

Section: Introductionmentioning

confidence: 99%

Hematological effects of benzene in the petroleum industry

Liao

2015

IJH

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Purpose: To follow up the hematological changes in petroleum workers with continuous exposure to benzene.Approach: The hematological data of two petroleum company male employees was obtained from the annual health check-ups during 2001 to 2005. Workers were classified into exposed and unexposed groups on the basis of their exposure operation performed, and the industrial hygiene surveys.Results: There was not any difference between the exposed and the unexposed groups in the frequency of abnormalities with CBC differential and WBC differential almost. The frequency of higher than the normal range with eosinophils was significantly higher in exposed group (31.73%) than in unexposed group (11.54%, p < 0.05) in 1994, only.Conclusion: The study suggested that the eosinophil counts could be a hematological effect maker among workers exposed to benzene in the petroleum industry.

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“…A small number of cohort studies (13)(14)(15)(16)(17)(18) have reported on the hematologic effects of benzene as monitored by routine counts of peripheral blood cells in groups of workers. Significant abnormalities of all three cell types were reported in individuals with high exposure from the preWorld War II era in the U.S. and in Turkey from the 1960s and 1970s (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure.

Kipen¹,

Cody²,

Goldstein³

1989

Environ Health Perspect

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We studied over 17,000 peripheral blood counts, accumulated during hematologic surveillance from 1940 through 1975, from a cohort of 459 benzene-exposed workers. Linear regressions demonstrated significant decreases in white and red cell counts, as well as hemoglobin, for workers exposed during the 1940s, without persistent trends over the ensuing 25 years. Strongly positive correlations were observed between these blood count fluctuations and fluctuations in retrospective estimates of benzene exposures for these workers in the earlier period of surveillance (mean estimated exposure 1940 to 1948, 75 ppm); but not for later years, (mean estimated exposure 1948 to 1975, 15 to 20 ppm). These data suggest substantial limitations of hematologic examination of populations to detect abnormalities in populations currently exposed to benzene. The analysis also demonstrates a novel approach to the biological validation of exposure estimates based upon limited industrial hygiene and historical record data. The application of biologic monitoring data may be useful for assisting decisions in reconstruction of a previous exposure.

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Effects of Chronic Occupational Exposure to Measured Concentrations of Benzene

Cited by 28 publications

References 0 publications

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

Hematological effects of benzene in the petroleum industry

Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure.

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