Effects of Chronic Peripheral Venous Congestion on Renal Sodium Excretion

Frieden, Julian; Rice, Lester; Elisberg, Edward I.; Eisenstein, Bernard; Katz, Louis N.

doi:10.1152/ajplegacy.1952.168.3.650

Cited by 10 publications

(1 citation statement)

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“…These infusions, however, undoubtedly did not prevent local pooling of blood (in the lower extremities), transudation in the area of increased venous pressure, and consequent redistribution of the flow and volume of the circulating blood. The importance of these factors in the control of salt excretion may be inferred from studies of other abnormal circulatory states in which they may also be operative: Sodium retention occurs with the venous congestion produced by tourniquets on the limbs (21) or by obstruction of the inferior vena cava (22,23) and with the portal congestion of decompensated hepatic cirrhosis (24) just as it does when a large volume of blood is actually removed from the circulation by hemorrhage (25). With venous obstruction, cardiac output and arterial blood pressure tend to fall (26).…”

Section: A Infusions Of Mannitolmentioning

confidence: 99%

The Effects of Quiet Standing on Solute Diuresis 1

Goodyer¹,

Seldin²

1953

J. Clin. Invest.

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Section: A Infusions Of Mannitolmentioning

confidence: 99%

The Effects of Quiet Standing on Solute Diuresis 1

Goodyer¹,

Seldin²

1953

J. Clin. Invest.

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Renal Function During General Anesthesia and Operation

Papper¹

1953

JAMA

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does not alter the mode of entrance of these drugs. In the presence of an unobstructed common bile duct and normal liver function the drugs are excreted from the liver into the biliary tract in high concentration. In the presence of an actively obstructed common bile duct or impaired liver function the drugs are excreted either not at all or in very small concentrations. When obstruction is overcome and liver function improves, the drug is again excreted in high concentration.The local pathological changes of acute obstructive calculous cholecystitis are not affected by the therapeutic agents studied. In an occasional case acute non¬ calculous cholecystitis may be cured by one of these agents. In the usual mild case of acute obstructive cal¬ culous cholecystitis the clinical course is not affected by the administration of these drugs. In the gravely ill pa¬ tient with acute obstructive cholecystitis the systemic symptoms are often relieved by the administration of these drugs; the local process appears to be unaffected.The percentage of cases of acute obstructive cholecystitis with empyema or perforation is the same, whether or not the drugs are used. The drugs should be used in cases of acute cholecystitis with systemic manifestations in order to better prepare patients for operation. The availability of these drugs should not alter the indications for opera¬ tion in acute cholecystitis.In patients with obstructive jaundice the drugs do not overcome any active local infection as long as the obstruc¬ tion persists. When obstruction is relieved, the drugs are excreted in high concentration and may be expected to aid the natural healing processes. During active common bile duct obstruction the drugs should be given to protect the liver from ascending infection. During active com¬ mon bile duct obstruction the drugs often do relieve any associated systemic symptoms, making these patients better operative risks. The availability of these drugs should not alter the indications for operation in cases of obstructive jaundice with cholangitis. They should be used only as adjuncts both in the preoperative and post¬ operative periods.Interest in renal function during anesthesia and operation and in the postoperative period has increased greatly in recent years. There has been an intensive effort to gain further knowledge about renal activity in surgical patients, with a greater appreciation of the subtle physiological changes that occur during and after operation. Renal function was not previously emphasized in care of surgical patients because of pressing demands for study of cardiovascular function and respiration, which are immediate problems in every surgical patient. Although not so apparent, the influence of the kidney on the ultimate success of surgical procedures is no less striking. This paper reviews briefly some of the aspects of renal function during anesthesia and surgery. Perhaps it is not generally realized that the kidney is a circulatory organ of considerable importance; it normally accommodates approximat...

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