Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants

Neto, Nicolau Conte; Andrade, Cléverton Roberto de; Spolidorio, Luís Carlos; Planeta, Cleópatra da Silva; Cruz, Fábio C.; Bastos, Alliny de Souza; Marcantônio, Élcio

doi:10.1111/cid.12046

Cited by 7 publications

(17 citation statements)

References 51 publications

(62 reference statements)

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“…The high-dose group exhibited greater potential to promote osseointegration than the low-dose group. Moreover, the effect of CatKI on the removal torque values and BIC observed in this study is comparable to that of ALN noted in the previous studies2930.…”

Section: Discussionsupporting

confidence: 90%

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Hao

et al. 2017

Sci Rep

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The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous implants. The inhibitors of cathepsin K (CatK) significantly affect bone turnover, bone mineral density (BMD) and bone strength in the patients with osteoporosis. Therefore, we hypothesised that the application of a CatK inhibitor (CatKI) could increase the osseointegration of endosseous implants under osteoporotic conditions. Odanacatib (ODN), a highly selective CatKI, was chosen as the experimental drug. Sixteen rats were randomised into 4 groups: sham, ovariectomy (OVX) with vehicle, OVX with low-dose ODN (5 mg/kg) and OVX with high-dose ODN (30 mg/kg). Titanium implants were placed into the distal metaphysis of bilateral femurs of each OVX rat. After 8 weeks of gavaging, CatKI treatment increased the removal torque, BMD and bone-to-implant contact (BIC). Moreover, high-dose CatKI exerted a better influence than low-dose CatKI. Furthermore, CatKI treatment not only robustly suppressed CatK gene (CTSK) expression, but also moderately reduced expression of the osteoblast-related genes Runx2, Collagen-1, BSP, Osterix, OPN, SPP1 and ALP. Thus, CatKI could affect the osteoblast-related genes, although the balance of bone turnover was achieved mainly by CatK inhibition. In conclusion, CatKI prevented bone loss and aided endosseous implantation in osteoporotic conditions.

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Section: Discussionsupporting

confidence: 90%

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Hao

et al. 2017

Sci Rep

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“…These results also show that, during the osseointegration period, the rats in the chronic stress group did not adapt to the stress protocol. 9,29 The cortisol levels can be evaluated as physiological data related to the presence of stress, and this study shows that the experimental stress model increases cortisol in the bloodstream. 9,29 Stress can suppress or stimulate the immune system, and activates the hypothalamic-pituitaryadrenal pathway.…”

Section: Discussionmentioning

confidence: 89%

“…9,29 The cortisol levels can be evaluated as physiological data related to the presence of stress, and this study shows that the experimental stress model increases cortisol in the bloodstream. 9,29 Stress can suppress or stimulate the immune system, and activates the hypothalamic-pituitaryadrenal pathway. Activation of this pathway results in the release of neuroendocrine and adrenal corticosteroid hormones, making people susceptible to disease.…”

Section: Discussionmentioning

confidence: 89%

“…In addition, some experimental animal studies have reported that glucocorticoids delay soft-tissue wound healing and thereby adversely affect bone-implant connections. 7,8,9,0 Dental implant-supported prostheses are a commonly used and scientifically accepted treatment option for both partial and complete edentulism. However, the systemic condition of the patient, the quality of the bone, the shape and surface characteristics of the implant, and smoking habits are all important factors in relation to the success of dental implant therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Although there is a growing body of evidence suggesting that chronic stress negatively affects wound healing, the effects of stress on the bone-implant connection (BIC) have not yet been fully investigated in the literature and hence remain controversial. 8,9,11,12 The aim of this study was to investigate the effects of an HFD and chronic stress on the osseointegration of titanium implants in the tibial bones of rats.…”

Section: Introductionmentioning

confidence: 99%

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Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study

et al. 2020

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This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.

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Osseointegration Pharmacology: A Systematic Mapping Using Artificial Intelligence

Mahri

Shen²,

Berrizbeitia³

et al. 2021

Acta Biomaterialia

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Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants

Abstract: Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects.

Cited by 7 publications

References 51 publications

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats

Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study

Osseointegration Pharmacology: A Systematic Mapping Using Artificial Intelligence

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