Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation

Zhang, Hao; Yang, Yuwei; Cao, Yan; Guan, Jingzhi

doi:10.1016/j.biopha.2024.116609

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116609

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Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation

Hao Zhang,

Yuwei Yang,

Yan Cao

et al.

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2024

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Cited by 2 publications

References 282 publications

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Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

Fan,

Liang,

Tang

2024

MedComm

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Cancer neuroscience is an emerging field that investigates the intricate relationship between the nervous system and cancer, gaining increasing recognition for its importance. The central nervous system governs the development of the nervous system and directly affects brain tumors, and the peripheral nervous system (PNS) shapes the tumor microenvironment (TME) of peripheral tumors. Both systems are crucial in cancer initiation and progression, with recent studies revealing a more intricate role of the PNS within the TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating a bidirectional interaction between nerves and cancers. Notably, immune cells also contribute to this communication, forming a triangular relationship that influences protumor inflammation and the effectiveness of immunotherapy. This review delves into the intricate mechanisms connecting the PNS and tumors, focusing on how various immune cell types influence nerve‒tumor interactions, emphasizing the clinical relevance of nerve‒tumor and nerve‒immune dynamics. By deepening our understanding of the interplay between nerves, cancer, and immune cells, this review has the potential to reshape tumor biology insights, inspire innovative therapies, and improve clinical outcomes for cancer patients.

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Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

Fan,

Liang,

Tang

2024

MedComm

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Neurobiology of cancer: Adrenergic signaling and drug repurposing

Dong,

Wang,

et al. 2024

Pharmacology & Therapeutics

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Effects of chronic stress on cancer development and the therapeutic prospects of adrenergic signaling regulation

Cited by 2 publications

References 282 publications

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

Neurobiology of cancer: Adrenergic signaling and drug repurposing

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