Effects of Chronic Treatment with a Water-Alcohol Extract from Erythrina mulungu on Anxiety-Related Responses in Rats

Onusic, Gustavo Massaro; Nogueira, Ricardo de Carvalho; Pereira, Ana Maria Soares; Flausino, Júnior Otavio Aparecido; Viana, Milena de Barros

doi:10.1248/bpb.26.1538

Cited by 34 publications

(35 citation statements)

References 21 publications

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“…Some researches already showed many effects of these species in rodents, like the sedative and neuromuscular blocking actions from the crude extract from the leaves of E. velutina (Dantas et al, 2004), the antinociceptive and the depressant activities of the hydroalcoholic extracts (HAE) from the stem bark of both species (Vasconcelos et al, 2003;2007) and the anxiolytic effect of the HAE from the inflorescence of E. mulungu and from the stem bark of E. velutina (Onusic et al, 2003;Sarragiotto et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan-and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24 th h. Em (200 or 400 mg/kg) presented antiinflammatory effect at the 2, 3 and 4 th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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“…In herbal medicine, EM is used to calm agitation and for insomnia and other disorders of the nervous system. In previous studies from our laboratory (7,8), the effects of acute and chronic treatment with a water-alcohol extract of the inflorescence of EM were investigated in rats submitted to models specifically related to different types of anxiety disorder: the elevated T-maze (ETM, for inhibitory avoidance and one-way escape measurements), the light/dark transition, and the cat odor tests. Acute treatment with EM altered both inhibitory avoidance latencies in the ETM and the behavior of rats in the light/dark transition model, in a way similar to DZP.…”

Section: Introductionmentioning

confidence: 99%

<a name="home"></a>Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression

Ribeiro

Onusic

Poltronieri

et al. 2006

Braz J Med Biol Res

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Erythrina velutina (EV) and Erythrina mulungu (EM), popularly used in Brazil as tranquilizing agents, were studied. The effects of acute and chronic oral treatment with a water:alcohol extract of EV (7:3, plant grounded stem bark; acute = 100, 200, 400 mg/kg; chronic = 50, 100, 200 mg/kg) were evaluated in rats (N = 11-12) submitted to the elevated T-maze (for avoidance and escape measurements) model of anxiety. This model was selected for its presumed capacity to elicit specific subtypes of anxiety disorders recognized in clinical practice: avoidance has been related to generalized anxiety and escape to panic. Additionally, animals were treated with the same doses of EV and EM (water:alcohol 7:3, inflorescence extract) and submitted to the forced swim test for the evaluation of antidepressant activity (N = 7-10). Both treatment regimens with EV impaired elevated T-maze avoidance latencies, without altering escape, in a way similar to the reference drug diazepam (avoidance 1, mean ± SEM, acute study: 131.1 ± 45.5 (control), 9.0 ± 3.3 (diazepam), 12.7 ± 2.9 (200 mg/kg), 28.8 ± 15.3 (400 mg/kg); chronic study: 131.7 ± 46.9 (control), 35.8 ± 29.7 (diazepam), 24.4 ± 10.4 (50 mg/kg), 29.7 ± 11.5 (200 mg/kg)). Neither EV nor EM altered measurements performed in the forced swim test, in contrast to the reference drug imipramine that significantly decreased immobility time after chronic treatment. These results were not due to motor alterations since no significant effects were detected in an open field. These observations suggest that EV exerts anxiolytic-like effects on a specific subset of defensive behaviors which have been associated with generalized anxiety disorder.

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“…The cloth was placed in a corner in the cage. In the control group 3 rats were housed in a cage and were exposed to a clean cloth (20)(21)(22)(23)(24)(25). The rats in both groups received drinking water and standard laboratory food ad libitum during the study period.…”

Section: Methodsmentioning

confidence: 99%

Effect of psychological stress on orthodontic tooth movement in rats

Mirzakouchaki

Firoozi²,

Shahrbaf³

2011

Med Oral

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Introduction: The purpose of this study was to investigate the effect of psychological stress on orthodontic tooth movement in Wistar rats. Materials and methods: Forty-eight female ten-week old Wistar rats with an average weight of 188 ±12 gr were selected and randomly divided into two experimental and control groups. The experimental group received crowded environment-induced and cat odour stresses 4 weeks before spring insertion. On the 29th day in both groups, maxillary incisors were moved by the insertion of springs and exactly after 7 days, 9 rats from each group and after 14 days the remaining rats were sacrificed. Then the mesioincisal distance between maxillary incisors was measured. Afterwards, histological sections were prepared to count osteoclasts under a light microscope. The data on the extent of orthodontic tooth movement and the number of osteoclasts were analyzed by independent sample t-test. Results: The results indicated that on the 7th day after spring placement the orthodontic tooth movement was significantly higher in the control group compared to the experimental group (p<0.05). The number of osteoclasts at a significance level of α=0.1 in the control group was higher compared to the experimental group. On the 14th day after spring placement, the orthodontic tooth movement in the control group was significantly higher compared to the experimental group (p<0.05). However, there were no significant differences in the number of osteoclasts between the two groups. The rats experienced weight loss in the experimental group (p<0.05). Conclusions: Psychological stress led to a decrease in orthodontic tooth movement and in the number of osteoclasts around the root in the movement direction in rats, but a decrease in osteoclast counts was not parallel with time and demonstrated a nonlinear pattern. In addition, psychological stress led to weight loss in rats.

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Effects of Chronic Treatment with a Water-Alcohol Extract from Erythrina mulungu on Anxiety-Related Responses in Rats

Cited by 34 publications

References 21 publications

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

<a name="home"></a>Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression

Effect of psychological stress on orthodontic tooth movement in rats

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