Effects of chronically administered venlafaxine on 5-HT receptor activity in rat hippocampus and hypothalamus

Gur, Eitan; Dremencov, Eliyahu; Kar, Louis D. Van de; Lerer, Bernard; Newman, Morris

doi:10.1016/s0014-2999(01)01578-3

Cited by 21 publications

(8 citation statements)

References 47 publications

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“…Our results provide further support for the theory (Moret and Briley, 2000;Dremencov et al, 2002) that induction of subsensitivity of 5-HT 1B autoreceptors in the hypothalamus is a characteristic effect of chronic treatment of experimental animals with antidepressant drugs. This phenomenon was observed by Sayer et al (1999) using in vivo microdialysis with the tricyclic drug desipramine and the SSRI paroxetine, and has been observed by us using the same technique after chronic administration to rats of the tricyclic clomipramine (Newman et al, 2000b) and the serotonin and noradrenaline uptake blocker venlafaxine (Gur et al, 2002b). In frontal cortex we have shown a similar phenomenon after repeated transcranial magnetic stimulation .…”

Section: Discussionsupporting

confidence: 78%

Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences

Lifschytz

Gur

Lerer

et al. 2004

Journal of Neuroscience Methods

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Section: Discussionsupporting

confidence: 78%

Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences

Lifschytz

Gur

Lerer

et al. 2004

Journal of Neuroscience Methods

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“…Neither were abnormalities found in the animals' general health or demeanor. In fact, the doses used in the present study have been demonstrated to be effective in animal models (Stockert et al, 1988;Bodnoff et al, 1989;Malatynska et al, 1995;Ferretti et al, 1995;McGrath and Norman 1998;Gur et al, 2002). Although we have not yet determined the causative factors for this paradox, the dose-related effects of the drugs on the BDNF immunostaining in hippocampal neurons may have functional significance and should be explored further.…”

Section: Discussionmentioning

confidence: 82%

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Richardson

2003

Neuropsychopharmacol

157

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It has been proposed that antidepressants have neuroprotective effects on hippocampal neurons. To further test this hypothesis, brainderived neurotrophic factor (BDNF), B cell lymphoma protein-2 (Bcl-2), and copper-zinc superoxide dismutase (Cu/Zn-SOD) were examined immunohistochemically in hippocampal neurons of Sprague-Dawley rats following daily treatment with 5 or 10 mg/kg of amitriptyline or venlafaxine for 21 days. At 5 mg/kg, both amitriptyline and venlafaxine increased the intensity of BDNF immunostaining in hippocampal pyramidal neurons, and the intensity of Bcl-2 immunostaining in hippocampal mossy fibers, but did not alter the Cu/Zn-SOD immunoreactivity. The high dose of venlafaxine, however, decreased the intensity of BDNF immunostaining in all subareas of the hippocampus and increased the intensity of Cu/Zn-SOD immunostaining in the dentate granular cell layer. The high dose of amitriptyline increased the intensity of Cu/Zn-SOD immunostaining, but did not affect the immunoreactivity of Bcl-2 or BDNF. These findings suggest that the chronic administration of amitriptyline or venlafaxine at 5 mg/kg, but not 10 mg/kg, may be neuroprotective to hippocampal neurons. These dose-related effects of antidepressant drugs on hippocampal neurons may have relevance to disparate findings in the field.

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“…In the hippocampus, discrepancies cannot be explained by the specific subregions investigated. For example, no changes in 5-HT levels after all classes of antidepressants have been observed in both the dorsal (Bosker et al, 1995a(Bosker et al, , 1995bAuerbach, 1994, 1999;Invernizzi et al, 1995;Keck et al, 2005;Tachibana et al, 2006) and the ventral hippocampus (Gardier et al, 2003;Gur et al, 1999aGur et al, , 1999bGur et al, , 2002aNewman et al, 2000). Washout times are also not likely to be responsible for the discrepancies.…”

Section: Introductionmentioning

confidence: 97%

“…The most striking discrepancies are observed in studies using SSRIs, including citalopram (Gundlah et al, 1997;Auerbach, 1994, 1999;Invernizzi et al, 1995;Wegener et al, 2003), fluoxetine (Kreiss and Lucki, 1995), fluvoxamine (Bosker et al, 1995a(Bosker et al, , 1995bTachibana et al, 2006), and paroxetine (Gardier et al, 2003;Hajos-Korcsok et al, 2000;Keck et al, 2005). Chronic administration of tricyclic antidepressants (Gur et al, 1999b;Hajos-Korcsok et al, 2000;Newman et al, 2000) and SNRIs (Gur et al, 1999a(Gur et al, , 2002aTachibana et al, 2006) more consistently show no increase hippocampal dialysate 5-HT levels.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, treatment with the tricyclic antidepressants imipramine (Gur et al, 2004) or desipramine (Sayer et al, 1999) did not change 5-HT levels in hypothalamus, while clomipramine was reported to increase dialysate 5-HT (Newman et al, 2000). Only one SNRI, venlafaxine, has been studied and it was found to have no effect on dialysate hypothalamic 5-HT (Gur et al, 2002a). With the exception of the study by Moret and Briley (1996), all of the papers pertaining to hypothalamus utilized a minimum of 24 h for drug washout.…”

Section: Introductionmentioning

confidence: 99%

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Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake

Luellen¹,

Gilman²,

Andrews³

2010

Experimental Models in Serotonin Transporter Research

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benzonitrile), recently developed for positron emission tomography (PET) imaging, has been investigated by autoradiography in mice lacking one or both copies of the SERT gene (Li et al., 2004). High densities of [ 3 H]AFM and [ 3 H]DASB binding were observed in the hippocampus, thalamus, raphe nuclei, and locus coeruleus of SERTþ/þ mice. SERTþ/À mice exhibited reduced binding to $50% of that detected in wildtype mice. As anticipated, no binding was observed for either ligand in any of the brain regions analyzed in SERTÀ/À mice (Li et al., 2004). Thus, there is agreement among published studies that intact serotonin transporter protein labeled by many different radioligands is reduced in a gene dose-dependent manner in SERT-deficient mice generated by alternate strategies in a variety of genetic backgrounds. Many studies have been conducted that have assessed the effects of long-term pharmacologic inhibition of serotonin reuptake on SERT protein levels. Here, the majority of studies conclude that a reduction in SERT occurs after chronic administration of selective serotonin reuptake inhibitors (SSRIs) to mice (

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Effects of chronically administered venlafaxine on 5-HT receptor activity in rat hippocampus and hypothalamus

Cited by 21 publications

References 47 publications

Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences

Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake

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