Effects of cigarette smoking on erectile dysfunction

Kovac, Jason R.; Labbate, Craig; Ramasamy, Ranjith; Tang, Dongdong; Lipshultz, Larry I.

doi:10.1111/and.12393

Cited by 78 publications

(39 citation statements)

References 49 publications

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“…Smoking has previously been linked with erectile dysfunction [34], probably mediating its effects via microvascular circulatory impairment, although the mechanism in women has not been well studied. Regular exercise would likely counteract this mechanism, and our data suggest an association with sexual function score, and satisfaction with sexual function after adjusting for depression and fatigue.…”

Section: Discussionmentioning

confidence: 99%

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

et al. 2016

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BackgroundSexual dysfunction (SD) is very common in people with multiple sclerosis (PwMS) and contributes a significant burden of disease, particularly for young people. SD has direct neurological contributions from depression and fatigue, which occur commonly in PwMS. Modifiable factors may represent potential targets for treatment and prevention of SD. We aimed to assess the prevalence of SD and explore associations between SD and demographic and modifiable risk factors, as well as depression and fatigue in a large cohort of PwMS.MethodsWe analysed self-reported data from a large, international sample of PwMS recruited via Web 2.0 platforms, including demographic, lifestyle and disease characteristics. Specific sexual function questions included 4 items from the sexual function scale and 1 item regarding satisfaction with sexual function, part of the MS Quality of Life-54 instrument.Results2062 PwMS from 54 countries completed questions on sexual function. 81.1 % were women, mean age was 45 years, most (62.8 %) reported having relapsing-remitting MS. The majority (54.5 %) reported one or more problems with sexual function and were classified as having SD. Lack of sexual interest (41.8 % of women), and difficulty with erection (40.7 % of men) were most common. The median total sexual function score was 75.0 out of 100, and 43.7 % were satisfied with their sexual function. Regression modeling revealed independent associations between sexual function and satisfaction and a range of demographic factors, including age, as well as depression risk, antidepressant use, and fatigue in PwMS.ConclusionThis cross-sectional study shows that SD and lack of satisfaction with sexual function are associated with depression risk and fatigue, as well as modifiable lifestyle factors diet and physical activity (after adjusting for depression and fatigue). Planned longitudinal follow-up of this sample may help clarify these associations and the underlying mechanisms. There is potential to prevent and treat SD in PwMS by addressing depression and fatigue and their determinants. Clinicians and PwMS should be aware of SD and associated factors as part of a comprehensive preventive approach to managing MS.

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Section: Discussionmentioning

confidence: 99%

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

et al. 2016

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“…In another review examining the effect of smoking on ED, the risk caused by smoking in the development of ED was found to be higher in smokers compared to age and comorbidities. As a result of several studies, it has been concluded that smoking worsens erectile functions by disrupting vascular mechanisms (Kovac, Labbate, Ramasamy, Tang, & Lipshultz, ). The present study is in support of this data and similarly demonstrates high RDW levels are associated with ED.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of red cell distribution width on erectile dysfunction

et al. 2019

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Red cell distribution width (RDW), one of the biomarkers used to measure vascular ageing, is known to correspond with cardiovascular diseases. As coronary artery disease and erectile dysfunction (ED) are both caused by the same shared pathophysiology, in this study, we compared the RDW values of men diagnosed with ED and those of healthy controls. Ninety‐nine patients who were diagnosed with ED were included in the study. The control group consists of 100 men who presented to our outpatient clinic. Patients' fasting blood glucose, triglyceride, total cholesterol and LDL cholesterol levels were significantly higher in men diagnosed with ED. While the mean RDW value was 13.49 ± 1.52 in men with ED, it was 12.91 ± 1.13 in the control group. When RDW values were compared between the two groups, the RDW values of men with ED were found to be statistically significantly higher. Multivariate analyses showed that only the patients' body mass index, fasting blood sugar, triglyceride (TG), low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol levels (HDL‐C), TG/HDL‐C ratio and RDW levels' relationship with ED was statistically significant. Although some studies have shown that RDW may be related to some diseases such as cardiovascular diseases and cancer, this appears to be the first study demonstrating a relationship between RDW and ED. RDW can be utilised as a predictor for the determination of the presence and monitoring of the severity of ED.

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“…The coronary artery tone is also influenced by smoking, which impacts the coagulation mechanisms dependent on nitric oxide. In animal models, it was found that chronic smoking can potentially cause an ageindependent high blood pressure with a significant decline in nitric oxide synthesis in the penis [16] .…”

Section: Smoking and Endothelial Dysfunctionmentioning

confidence: 99%

Smoking and Vascular Disease

Alabdalqadir

Aldrees

Sayah

et al. 2018

Egyptian Journal of Hospital Medicine

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Background:Smoking is considered a crucial predisposing factor for the development of carotid diseases, cardiovascular disease, and peripheral artery disease. Around 10% of Americans have peripheral artery disease that is most likely related to smoking, and smoking is strongly associated with abdominal aortic aneurysms. The most important cause of death among smokers continues to be cardiovascular diseases. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: smoking, cardiovascular diseases, abdominal aortic aneurysms, peripheral vascular diseases, tobacco chemicals, smoking effects on blood vessels Aim: In this review, we aim to study the pathophysiology and mechanism of adverse effects caused by cigarette smoking upon the vascular system. Conclusion: Exposure to smoking both directly and indirectly is associated with significant increase in strokes, coronary heart diseases, aneurysms, and peripheral artery diseases. Atherosclerosis is also strongly associated with cigarette smoking. Smoking cessation will rapidly improve the overall health status and decrease the risk of cardiovascular diseases. More studies are needed to evaluate and assess mechanisms associated with smoking-related cardiovascular diseases.

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Effects of cigarette smoking on erectile dysfunction

Cited by 78 publications

References 49 publications

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

The predictive value of red cell distribution width on erectile dysfunction

Smoking and Vascular Disease

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