Effects of cigarette smoking on morphological features of platelets in healthy men

Ghahremanfard, Farahnaz; Semnani, Vahid; Ghorbani, Raheb; Malek, Farhad; Behzadfar, Ali; Zahmatkesh, Mehrdad

doi:10.15537/smj.2015.7.11026

Cited by 16 publications

(17 citation statements)

References 24 publications

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“…This result was in the line with the ROA Mustafa study, 15 that, smoking significantly reduced platelet count (212.30±55.71 vs. 238.23±36.89×10 9 /l) and previous study carried out by Metta S et al, 16 in 2015 reported that, platelet count was significantly lower in chronic smokers. The current results was not in agreement with the findings stated by Ghahremanfard et al, 17 who concluded that, the mean platelet count was significantly higher in adult smokers than in adult non-smokers and Al-Dahr study, 18 reported that, no significant difference between adult smokers and non-smokers regarding platelet count. Concerning PT the current study revealed that, the mean PT was significantly shorter in smokers when compared to the non-smokers, (12.9±1.15s versus 13.7±1.04s, p <0.000), the significantly reduced PT value was agreed with the results obtained by Akpotuzor et al, 19 who reported that, mean prothrombin time values of smokers were significantly lower when compared with the non-smokers and disagree with the findings obtained from the study carried out by Metta S et.al, 16 who showed that no significant difference in PT, on the other hand the current study results regarding PT value inconsistent with the results of Al-Dahr study, 18 who reported that PT was not changed significantly in the smoker groups.…”

Section: Discussioncontrasting

confidence: 99%

Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Elkhalifa

2018

SMJ

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Objectives:To study the effects of heavy cigarette smoking on coagulation (CGG) screening tests and platelet counts (PLTs) in a Sudanese male adults population.Methods:A case control study was conducted at both Kosti and Gabalein towns, Sudan, during October 2016 to May 2017. A 100 adult cigarette smokers were selected and another 100 matched non-smokers were selected as healthy controls. Blood samples were collected in trisodium citrate anti-coagulant for prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR), analyzed using standard methods (co-agulometer machine) and Ethylenediaminetetraacetic acid for the platelet counts, using an automated haematology analyzer (Sysmex, Tokoyo, Japan).Results:The results showed that the mean platelet counts were significantly lower in the smokers (183x103/cmm±64x103/cmm) versus (244x103/cmm±38x103/cmm) in non-smokers, (p<0.000). Pearson correlation analysis suggested a weak negative correlation between platelet counts with the duration of smoking (r= -0.289, p<0.004) and the age of the smokers (r= -0.238, p<0.017). The mean PT and INR were also significantly lower in smokers (12.9±1.2 seconds) compared with the non-smokers (13.7±1.04 seconds, p<0.000), for PT and (0.95±0.09 versus 1.01±0.08, p<0.000) for INR. In contrast, PTT had no significant variation in smokers (30.5±3.8 seconds) and the non-smokers (37.9±4.6 seconds). A p-value>0.05 was considered significant.Conclusion:Cigarette smokers tend to have lower platelet counts, shorter PT, and INR values, compared to non-smokers. Therefore, smoking might be associated with bleeding disorders but further investigations are needed.

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Section: Discussioncontrasting

confidence: 99%

Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Elkhalifa

2018

SMJ

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“… 1 Recently, the role of cigarette smoking in abnormalities in platelet activation and aggregation, along with other coagulation processing disruptions resulting in thrombotic formations, has been suggested. 2 In smokers, the endothelial lining is damaged, which causes platelets to adhere to the subendothelial collagen and therefore, the number of platelets in circulation might vary. There have been conflicting results in previous studies on the effect of smoking on platelet counts.…”

Section: Introductionmentioning

confidence: 99%

The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

Pujani

Chauhan

Singh

et al. 2021

Hematology, Transfusion and Cell Therapy

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Introduction Smoking is associated with the occurrence and progression of cardiovascular diseases, inflammatory disorders and malignancies. Objective To study the platelet indices, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in smokers and their correlation with smoking pack-years. Method A total of 110 smokers and 110 non-smokers were included. The smokers were grouped into three groups: mild (<5 pack-years), moderate (5−10 pack-years) and heavy (>10 pack-years). The platelet count, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were noted. The NLR and PLR were calculated and the statistical analysis was made using the Student’s T-test, Analysis of Variance (ANOVA) and Spearman’s correlation coefficient. Results The platelet count, PCT and PDW were significantly higher with mean values: 218.56 ± 121.31 vs 203.23 ± 80.35 ( p -value = 0.038), 0.27 ± 0.10 vs 0.26 ± 0.10 ( p -value = 0.041) and 12.54 ± 1.45 vs 11.99 ± 1.70 ( p -value = 0.001) in smokers and non-smokers, respectively. The PLR differed significantly with mean values: 119.40 ± 84.81 in smokers and 181.99 ± 313.09 in non-smokers, with a p -value of 0.045. A significant positive correlation was found between pack-years of smoking and platelet count and PLR with the Pearson correlation coefficient of 0.250 and 0.198 and p -values, 0.008 and 0.037, respectively. The Platelet Count, PCT, MPV and PDW varied significantly between mild, moderate and heavy smoker groups, with p -values of 0.045, 0.010, 0.015 and 0.017, respectively. Conclusion The platelet indices and inflammatory markers NLR and PLR are derived from routine blood investigations, which are easily available and inexpensive. The monitoring of platelet indices, along with the PLR, can be used as early predictors of morbidity in smokers.

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“…We suggest that the dose of ASA should be kept at twice a day in patients with higher anticipated turnover, such as smokers or diabetics. 26 27 …”

Section: Discussionmentioning

confidence: 99%

Use of pCONUS HPC for the treatment of unruptured wide-necked bifurcation aneurysms: early clinical experience using single antiplatelet therapy

et al. 2020

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BackgroundIn recent years, a growing number of stents and stent-like devices have become available to facilitate the treatment of challenging aneurysms. However, the need for dual antiplatelet therapy can limit their use, especially in ruptured aneurysms. The hydrophilic polymer coating (pHPC, phenox) is a novel glycan-based multilayer polymer that reduces platelet adhesion. This study aims to report our initial experience using the pCONUS HPC device for the treatment of unruptured wide-necked bifurcation aneurysms (WNBA) using acetylsalicylic acid (ASA) as single antiplatelet therapy (SAPT).MethodsWe retrospectively identified all patients who were treated with the pCONUS HPC for unruptured WNBA in a multi-staged procedure using ASA as SAPT. Records were made of periprocedural complications, clinical outcome and angiographic and clinical follow-up.ResultsWe identified 15 patients with 15 WNBA. The average age was 69 years old (range, 41–76). Seven aneurysms were located in the middle cerebral artery, five in the anterior communicating artery, two at the basilar tip and one in the posterior communicating artery. Immediate post-treatment angiography showed five aneurysms with modified Raymond-Roy classification (mRRC) grade I and four aneurysms with mRRC grade II. There were no haemorrhagic complications. Four patients developed thrombus formation during the second treatment session, all of them completely resolving after administration of glycoprotein IIb/IIIa antagonists. Angiographic follow-up data were available for 10 patients and showed adequate occlusion (mRRC I or II) in eight aneurysms (80%). In-stent stenosis was observed in one patient whereas two patients showed de novo stenosis in one of the efferent branches.ConclusionsThis early experience on the use of the pCONUS HPC device suggests that it can be useful for treating unruptured WNBA under ASA as SAPT. Further investigation with a randomised treatment registry and larger cohort is needed.

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Effects of cigarette smoking on morphological features of platelets in healthy men

Cited by 16 publications

References 24 publications

Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

The effect and correlation of smoking with platelet indices, neutrophil lymphocyte ratio and platelet lymphocyte ratio

Use of pCONUS HPC for the treatment of unruptured wide-necked bifurcation aneurysms: early clinical experience using single antiplatelet therapy

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