Effects of cimetidine and atropine sulfate in gastric secretion and healing of gastric and duodenal ulcers in rats

Okabe, Susumu; Takeuchi, Koji; Murata, Tomoki; Takagi, Keijiro

doi:10.1016/0014-2999(77)90209-6

Cited by 53 publications

(20 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comparison between this study and those of other workers (Okabe, Takata, Takeuchi, Naganuma & Takagi, 1976;Okabe, Takeuchi, Murata & Takagi, 1977) suggests that in the rat calcitonin may be more effective than carbenoxolone sodium and of comparable effectiveness to cimetidine in promoting the healing of acetic acid induced gastric ulcers.…”

Section: Pharnacokinetics Of Vitamin K In Young Andsupporting

confidence: 61%

Proceedings of the British Pharmacological Society

1980

British J Pharmacology

View full text Add to dashboard Cite

Section: Pharnacokinetics Of Vitamin K In Young Andsupporting

confidence: 61%

Proceedings of the British Pharmacological Society

1980

British J Pharmacology

View full text Add to dashboard Cite

“…Doses used to obtain clear-cut effect on GE were very much greater than those necessary to inhibit gastric secretion: however, in other studies (Okabe, Takeuchi, Murata & Takagi, 1977;Pare, Glavin & Vincent, 1978;Bunce, Daly, Humphray & Stables, 1980) similarly high amounts of H2 blockers had to be employed to obtain clear-cut effects on healing of experimentally induced ulcers in the rat.…”

Section: Discussionmentioning

confidence: 98%

HISTAMINE H₂‐ANTAGONISTS MODIFY GASTRIC EMPTYING IN THE RAT

Bertaccini

Scarpignato

1982

British J Pharmacology

View full text Add to dashboard Cite

1 Histamine H2-receptor antagonists were tested for their effect on gastric emptying in the rat. 2 At low doses all the compounds were inactive except for burimamide which delayed and ranitidine which accelerated gastric emptying. 3 At high doses burimamide, metiamide, cimetidine and oxmetidine delayed, whereas ranitidine accelerated gastric emptying; tiotidine remained ineffective. 4 Changes in emptying rate were not accompanied by changes in emptying pattern which, with all the compounds examined, proceeded, as in the controls, by apparent first order kinetics. 5 The mechanism of the ranitidine-induced acceleration of gastric emptying seemed to be connected with an interference with the cholinergic system, whereas the mechanism of cimetidineand oxmetidine-induced slowing of gastric emptying was apparently related to cholinolytic and possibly also relaxant effects of the compounds.6 These different effects of the various H2-blockers are consistent with the idea that changes in emptying rate are independent of H2-receptor blockade. IntroductionIn a thorough investigation concerning histamine receptors and gastrointestinal motility we observed that histamine delayed gastric emptying (GE) in the conscious rat through stimulation of HI-receptors (Bertaccini, Scarpignato, Coruzzi & Bertaccini, 1981). In a previous study (Bertaccini, Coruzzi, Molina & Chiavarini, 1977) it was also observed that the H2-blocker, burimamide, exerted a spasmogenic effect on the rat pylorus and other investigations carried out in our department (Scarpignato, Capovilla & Bertaccini, 1980;Bertaccini, De Castiglione & Scarpignato, 1981; have emphasized the importance of the pylorus in the regulation of gastric emptying in the rat. Several non-specific effects of the H2-receptor antagonists have been reported (Bertaccini & Dobrilla, 1980;Bertaccini, 1982): some of these effects concerned gut motility.We decided to investigate more thoroughly the effect of all the available H2-receptor antagonists on gastric emptying in the conscious rat. MethodsMale Wistar rats weighing approximately 200 g and fasted 24 h prior to experiments were used. Gastric emptyingThe test meal consisted of 1.5 ml/rat of a solution of 50 mg phenol red in 100 ml of aqueous methylcellulose (1.5%), given by oral intubation. H2-blockers were injected in a constant volume of saline (1 ml/kg), by the intraperitoneal route, 5 min before administration of the meal. The animals were killed at various time intervals after intubation to evaluate the duration of the pharmacological effects. The effect of the H2-blockers on gastric emptying as well as the interference of other pharmacological compounds was evaluated at a fixed time (20 min). This time was selected because gastric emptying at 20 min (54.5 ± 3.1%) allowed us to evaluate drug-induced acceleration or delay in emptying. Doses employed in this study were selected on the basis of the relative activity of the various drugs on gastric secretion. In each experiment a group of 4 animals was killed immediately after the meal a...

show abstract

“…Conversely, a significant delay in acetic acid ulcer healing was observed with propantheline and atropine (29,30). The healing of this experi mental ulcer was hastened by pirenzepine, an anti -chol1nergic, selective muscarinic an tagonist, and also by H2-receptor antagonists (25,31).…”

Section: Gastric Secretionmentioning

confidence: 99%