Effects of Cimetidine on Prostanoid Production in the Gastric Corpus Specimens from Rats

Abstract

Abstract-In order to examine the effect of cimetidine on the production of pro stanoids in the stomach mucosa, the amounts of prostaglandin (PG) E2, F1a and thromboxane (TX) B2 were determined after the specimens from the rat stomach corpus were incubated in the presence of cimetidine.Cimetidine significantly stimulated the production of PGE2 in the specimens at a concentration of 10 ,tM, but did not significantly affect the production of PGF1a and TXB2 at concentrations of 1 to 100 11M.