Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum

Mustafa, Ebtihal; Zarga, Musa Abu; Abdalla, Shtaywy

doi:10.1016/0306-3623(92)90127-6

Cited by 34 publications

(19 citation statements)

References 15 publications

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“…The mechanism of spread antibiotic resistance from food animals to humans remains controversial and resistance to the same drugs [47]. The most of the bacteria isolated from bovine mastitis showed a multidrug resistant for antibiotics due to the presences of drug resistant gene as beta lactimase which easily detected and evaluated by PCR as in Figure 4 this result is in agreement with [48]. The explanation of antibacterial activity of essential oil on bacterial cell depend on the action of terpenes fraction that involving their action by causing membrane perturbation and marked leakage of cytoplasmic material lead to induce irreversible damage to the cytoplasmic membran but fully action of terpenes still unknown and this explanation is agreement with [48,49].…”

Section: Discussionsupporting

confidence: 75%

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Zeedan¹

2014

J Microb Biochem Technol

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Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in treatment of antibiotic-resistant bacteria. The present study aimed to evaluate the efficacy of essential oil extracted from Achillea fragrantissima plant growing in Egypt for antimicrobial, antiviral activities and chemical composition analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). We also performed determination of essential oil antimicrobial activity by agar desk diffusion method and Minimal Inhibitory Concentration (MIC). Also, antiviral activity on ORF virus by pock reduction test was performed. It was reduced virus titer from 5.9 to 1.00 at 180 minutes. Detection of beta lactams resistant bacteria (Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis (MRSA) and Gram-negative bacteria Escherichia coli) by PCR with primers of mecA gene and Bela gene. The essential oil obtained by hydrodistillation was analyzed by GC-MS. The major components were found to be Santolina triene (1.97%), 2,5,5-trimethyl-3,6-heptadien-2-ol (8.23%) Eucalyptol 8.17, trans-2,7-Dimethyl-4,6octadien-2-ol (24.40%), 1,5-Heptadien-4-one-3,6-trimethyl (7.65%), Artemisia alcohol (3.49%), à Thujone (33.97%), Cissabinol (1.92%), Lavandulol (0.71%), 2-Octen-4-ol, 2-methyl (2.02%), 3-Cyclohexen1ol,4-methyl1 (1 methylethyl) (CAS) (2.15%), à terpineol ( 0.05% ), Estragole (0.71%) Lavandulyl acetate (0.49%), Sabinyl acetate (2.12 %), Germacrened (0.94%). Finally, our study proved that the essential oil has bactericidal effect on some bacterial resistant antibiotic (Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis (MRSA) and Gram-negative bacteria Escherichia coli ) as well as antiviral activity on ORF virus but it is still need further extensive studies for safety and drug interaction. Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential IntroductionMedicinal plants still constitute one of the major source of drugs in modern as well as traditional medicine throughout the world [1,2]. Since a long period of time, plants have been a valuable source of natural products for maintaining animals and human health [2,3]. The development of multidrug-resistant(MDR) bacteria takes place because of the accumulation of different antibiotic resistance mechanisms inside the same strain which able to live in the presence of antibiotics drugs so that standard treatments become ineffective [4,[14][15][16]. Although, the pharmacological companies have produced a number of new antibiotics recently, but even then microorganism resistance to antibiotics increased throughout the world [5,7]. This situation has attract attention of researchers towards herbal products for developing and improve the antibacterial drugs quality [6,7].Natural products of higher plants may possess a new source of antimicrobial agents with possibly novel mechanisms for treatment of infectious diseases [8,9]. Medicinal plants contain active principles which can be used as alternative effective herbal dru...

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Section: Discussionsupporting

confidence: 75%

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Zeedan¹

2014

J Microb Biochem Technol

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“…The exact phytochemicals responsible for the observed antiproliferative effects are precisely not known at the present time. Nevertheless, previous investigations have identified various groups of phytoconstituents, including flavones (e.g., cirsiliol), flavonols (quercetin glycosides) and triterpenoids (1,8-cineole, fragranol and terpenen-4-ol), present in the desert plants we studied (Afifi et al, 1991;Al-Dabbas et al, 2006a;Barakat et al, 1991;Dudai et al, 2003;El-Shazly et al, 2004;Mustafa et al, 1992). Several aforementioned compounds have demonstrated potent antitumor activities in several in vitro and in vivo models of liver cancer Thoppil & Bishayee, 2011).…”

Section: Discussionmentioning

confidence: 88%

“…It has been used for many years in traditional medicine in the Arabia region for the treatment of gastrointestinal complications (Segal et al, 1987). The extracts and phytoconstituents from this plant have been shown to possess antioxidant (Al-Mustafa & Al-Thunibat, 2008), anti-inflammatory (Ageel et al, 1989;Elmann et al, 2011), antispasmodic (Mustafa et al, 1992), antimicrobial (Abutbul et al, 2005;Barel et al, 1991;El-Shazly et al, 2004), antiviral (Soltan & Zaki, 2009) and hypoglycemic (Yaniv et al, 1987) activities. Sathiyamoorthy et al (1999) reported a strong cytotoxic effect of an aqueous extract of the A. fragrantissima against cultured melanoma cell lines.…”

Section: Discussionmentioning

confidence: 99%

Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells

Thoppil

Harlev

Mandal

et al. 2013

Pharmaceutical Biology

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Context: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer. Although many desert plants have been investigated for their antitumor properties, a large number of them still remain to be explored for possible therapeutic applications in oncologic diseases.

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“…fragrantissima has been used for many years in traditional medicine in Middle Eastern countries for the treatment of respiratory diseases, skin diseases, gastrointestinal disturbances, high blood pressure, stomach aches and diabetes [11][12][13][14]. Recent reports demonstrated anti-inflammatory, antioxidant and antiproliferative capacities of A. fragrantissima extracts [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Biological activities of the hydro-alcoholic and aqueous extracts of <i>Achillea fragrantissima</i> (Forssk.) grown in Jordan

Hammad¹,

Matar²,

Liţescu³

et al. 2014

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Aqueous and hydro-alcoholic extracts of Achillea fragrantissima L. (Asteraceae) grown in Jordan were screened for their antioxidant, antimicrobial, antiplatelet, anti-proliferative and acetylcholinesterase (AChE) inhibition efficacy. Total phenols and flavonoids were determined colorimetrically. The radical scavenging activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activity assays. High performance liquid chromatography-mass spectrometry (HPLC-MS) analysis resulted in the identification of 7 phenolic compounds in the hydro-alcoholic extract and 4 compounds in the aqueous extract; quercetin 3-β-D-glucoside was the main component for both extracts. Antimicrobial activities were determined by antimicrobial susceptibility testing such as agar well-diffusion method, minimum inhibition concentration and minimum bactericidal concentration. Gram positive bacteria showed sensitivity to hydro-alcoholic extract in the agar-well diffusion test. No significant activity was observed against gram negative bacteria and Candida albicans. Hydro-alcoholic extract had a bactericidal activity against Streptococcus pneumoniae and Bacillus cereus at high concentrations (MIC 12.5 mg/ml) rather than inhibitory effect. In vitro antiplatelet activity was tested on human whole blood using an electrical impedance method. At concentrations (50, 100, and 200 μg/ml), no effect on platelet aggregation was noticed. Anti-proliferative activity was investigated using the MTT assay. At concentrations up to 200 μg/ml, extracts did not possess cytotoxic activity against the MCF-7 cells. Acetylcholinesterase (AChE) inhibitory capacity of A. fragrantissima extracts was tested using TLC assay method, and neither aqueous, nor hydroalcoholic extracts showed AChE inhibition. The present investigation supported the traditional use of A. fragrantissima in the Jordanian folk medicine as an antimicrobial active representative of the genus Achillea. A. fragrantissima extracts should be further studied for their potential use in preventing/treating diseases in which oxidative stress is a part of the pathophysiology.

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Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum

Cited by 34 publications

References 15 publications

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells

Biological activities of the hydro-alcoholic and aqueous extracts of <i>Achillea fragrantissima</i> (Forssk.) grown in Jordan

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Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum

Cited by 34 publications

References 15 publications

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Antimicrobial, Antiviral Activity and GC-MS Analysis of Essential Oil Extracted from Achillea fragrantissima Plant Growing In Sinai Peninsula, Egypt

Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells

Biological activities of the hydro-alcoholic and aqueous extracts of &lt;i&gt;Achillea fragrantissima&lt;/i&gt; (Forssk.) grown in Jordan

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Biological activities of the hydro-alcoholic and aqueous extracts of <i>Achillea fragrantissima</i> (Forssk.) grown in Jordan