Effects of clarithromycin in patients with active rheumatoid arthritis

Öğrendik, Mesut

doi:10.1185/030079906x167642

Cited by 48 publications

(40 citation statements)

References 28 publications

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“…In 2006, Ogrendik reported a study of the use of clarithromycin for the treatment of RA [51]. This was a 6-month, randomized, double blind, and placebo-controlled study.…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Öğrendik¹

2014

OJRA

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A significant association has been shown to exist between periodontitis and rheumatoid arthritis (RA) in observational studies. Some intervention studies have suggested that periodontal treatment can reduce serum inflammatory biomarkers such as C-reactive protein, or erythrocyte sedimentation rate. Serum antibodies to oral bacteria have been found at increased levels in RA patients. In addition, DNAs from these bacteria have been identified from samples of RA patients. Several antibiotics are effective on RA. Finally, oral bacteria are responsible for the etiology of RA.

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“…In 2006, Ogrendik reported a study of the use of clarithromycin for the treatment of RA [51]. This was a 6-month, randomized, double blind, and placebo-controlled study.…”

Section: Macrolide Antibioticsmentioning

confidence: 99%

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Öğrendik¹

2014

OJRA

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“…CM showed a very rapid onset of action (10 days) and lowered the plasma levels of PLA2 and PGE2. More recently, Ogrendik [15] conWrmed the eYcacy of CM in a double-blind trial versus placebo in 81 RA patients obtaining a signiWcant improvement following ACR criteria. In 2006 Moskowitz [16] published a report of seven patients aVected by undiVerentiated connective tissues disease (UCTD) successfully treated with CM in a 12-week open-label study; he also conWrmed the very rapid onset of action (as early as 1 week).…”

Section: Introductionmentioning

confidence: 97%

Clarithromycin in adult-onset Still’s disease: a study of 6 cases

et al. 2009

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Adult-onset Still's disease (AOSD) is a rare rheumatological condition characterized by an acute systemic involvement. There are no treatment guidelines. Glucocorticoids (GC), methotrexate (MTX), cyclosporin A and biologic agents have been successfully used, often in association. We treated six cases of AOSD with clarithromycin (CM) in combination with low-mild dose of GC and MTX. Four of them were not responsive to high-dose GC added to DMARDs, while two of them were treated with low-mild dose of GC added to CM from the beginning. CM, 500 mg b.i.d., was added to a mild-low dose of GC and to MTX. The dose of the drugs was reduced (and stopped where possible) following clinical and laboratory parameters. ACR criteria were used to assess clinical improvement. At 6 months 5 patients reached ACR 70% and could stop any therapy in 6-18 months; 1 continued chronic therapy with low-dose GC added to CM and MTX to maintain ACR 50%. CM can be a useful drug for the treatment of AOSD, even in patients not responsive to high-dose GC and DMARDs. No definitive conclusion can be drawn based on the present study.

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“…The components of this barrier coalesce to minimize the contact and dilute any possible pathological microbial trigger between the commensal microbes in the gut lumen and intestinal epithelial cells that line the gut wall [50,51].…”

Section: Mucosal Bufer Zone: "Irst-line Defense"mentioning

confidence: 99%

The Gut Microbiota and Inflammation in Rheumatoid Arthritis

Mohammed¹,

Elmakhzangy²

2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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Abstract"Mutualism" is a well-deined relationship that describes a form of cooperation between two living organisms of diferent species that ends up with a beneicial outcome for each one. Any disruption to such a relationship by an external trigger or a potential intruder puts at risk the well-being of both. In humans, oral and gut microbiota provide a noteworthy model of beneicial mutualism. Multiple recent evidences point to the possible pathologic consequences of a disruption to this ecosystem (altered microbiota proile or dysbiosis) on human well-being. The gut-joint axis found its clear way "Proof of Principle" in the pathogenesis of autoimmune rheumatic diseases including rheumatoid arthritis (RA), seronegative spondyloarthropathies, and Behcet's disease in a number of studies. Current therapeutic trends are directed towards the diverse biologic and immune-pathogenic factors involved in the disease process. Addressing dysbiosis in RA features an atractive future therapeutic target. In this chapter, authors aim to explore the recent evidences regarding the pathogenic role of "gut dysbiosis" in rheumatoid arthritis (RA), highlighting the spectrum of immune-pathogenic events that might contribute to disease evolution and inspecting future directives of research.

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Effects of clarithromycin in patients with active rheumatoid arthritis

Abstract: In patients with early active rheumatoid arthritis, treatment with clarithromycin significantly improved the signs and symptoms of rheumatoid arthritis. Clarithromycin has been shown to be effective against rheumatoid arthritis.

Cited by 48 publications

References 28 publications

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Clarithromycin in adult-onset Still’s disease: a study of 6 cases

The Gut Microbiota and Inflammation in Rheumatoid Arthritis

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