The changes in climatic variables in Ethiopia are not entirely understood. This paper investigated the recent trends of precipitation and temperature on two eco-regions of Ethiopia. This study used the observed historical meteorological data from 1980 to 2016 to analyze the trends. Trend detection was done by using the non-parametric Mann-Kendall (MK), Sen's slope estimator test, and Innovative Trend Analysis Method (ITAM). The results showed that a significant increasing trend was observed in the Gondar, Bahir Dar, Gewane, Dembi-Dolo, and Negele stations. However, a slightly decreasing trend was observed in the Sekoru, Degahabur, and Maichew stations regarding precipitation trends. As far as the trend of temperature was concerned, an increasing trend was detected in the Gondar, Bahir Dar, Gewane, Degahabur, Negele, Dembi-Dolo, and Maichew stations. However, the temperature trend in Sekoru station showed a sharp decreasing trend. The effects of precipitation and temperature changes on water resources are significant after 1998. The consistency in the precipitation and temperature trends over the two eco-regions confirms the robustness of the changes. The findings of this study will serve as a reference for climate researchers, policy and decision makers.