Acute pancreatitis (AP) is an inflammatory disease with high mortality and morbidity, characterized by elevated amylase and lipase, accompanied by typical abdominal pain. In this case, we present a case of acute pancreatitis developed after the use of thiocolchicoside in a 52-year-old patient with a history of cholecystectomy. There was no history of intrahepatic and choledochal stones or enlargement, hyperlipidemia, and alcohol use on MRCP. After excluding the possible cause, a diagnosis of AP caused by thiocolchicoside, a rare side effect of this drug, was made. There are case reports about the development of AP secondary to drugs in the literature, but the development of AP after thiocolchicoid is extremely rare. It is important to determine the etiology in AP cases. It is aimed to raise awareness on this issue with this case, which shows that thiocolchicoid, which is frequently prescribed in primary and secondary health care institutions, may rarely cause AP.