Effects of Clonidine on Anesthetic Drug Requirements and Hemodynamic Response during Aortic Surgery

Engelman, Edgard; Lipszyc, M.; Gilbart, E.; Linden, Philippe Van der; Bellens, Bernard; Romphey, A. Van; Rood, M. de

doi:10.1097/00000542-198908000-00002

Cited by 165 publications

(32 citation statements)

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“…Similarly, lower fentanyl requirements in our clonidinetreated patients as well as our finding of decreased intraoperative SBP indirectly support the results of previous studies. On the other hand, uncontrolled hypotension and bradycardia are the major potential adverse effects of clonidine that may be encountered in intraoperative intravenous use of clonidine (18)(19)(20). In this study, the requirement for fluid challenge was comparable between the two groups, and no case of significant bradycardia was observed, which supports the safety of premedication with oral clonidine.…”

Section: Discussionsupporting

confidence: 73%

Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section

Ebneshahidi¹,

Mohseni

2011

Anesth Pain

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Background: Intentional lowering of blood pressure helps to produce a desirably clean surgical field. Many drugs can be used to induce a hypotensive state, but due to their high potency and rapid effect, drugs that more easily and safely control the induction of hypotension are desirable. Objectives: To investigate the effects of premedication with oral clonidine on intraoperative bleeding and hemodynamic variables in patients undergoing cesarean sections. Patients and Methods: A total of 110 patients classified as American Society of Anesthesiologists (ASA) physical status I and II and who were scheduled for elective cesarean section under general anesthesia were enrolled. The patients were randomized to receive either oral clonidine (0.2 mg) or identical-looking placebo tablets 90 minutes before arriving at the operating room. Induction of anesthesia was performed by the same standard protocol in all patients. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) and heart rate (HR) were recorded before and after induction; immediately after intubation; 5, 10, and 15 minutes thereafter; at the time of extubation; and one hour after the operation. The surgeons were asked to rate the quality of the operative field on a four-point scale that ranged from mild (1) to abundant bleeding (2). Results: Intraoperative SBP was lower in the clonidine group. After both intubation and extubation, the increases in SBP, DBP, and HR in clonidine-treated subjects were significantly less than the changes in the control patients. The amount of fentanyl given to control blood pressure and HR was significantly less in the clonidine group (18 ± 38 vs. 39 ± 53 μg, P = 0.02). The responses to the four-point scale indicated that intraoperative bleeding in the clonidine group was less than in the placebo group (1.2 ± 0.4 vs. 1.7 ± 0.6, P < 0.05). Conclusions: Premedication with oral clonidine can improve the hemodynamic management of cesarean cases.

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Section: Discussionsupporting

confidence: 73%

Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section

Ebneshahidi¹,

Mohseni

2011

Anesth Pain

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“…Without Clonidine it is mandatory to go up on concentrations of inhalational anaesthetics and narcotics to achieve desired hypotensive levels. 11,12 In our study, there was significant decrease in requirement of inhalational anaesthetics compared to placebo group.…”

Section: Discussionsupporting

confidence: 45%

Clonidine Premedication as a Desirable Part of Hypotensive Anaesthesia for Functional Endoscopic Sinus Surgery

Praveen¹,

R²

2016

jemds

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BACKGROUNDClonidine an ideal agent for hypotensive anaesthesia, also attenuates stress response to laryngoscopy, decreases requirement of inhalational anaesthetic agents, decreases postoperative analgesic requirements, prevents post-operative shivering. MATERIAL AND METHODS60 patients under 16-60 years age group posted for functional endoscopic sinus surgery (FESS) were randomly divided into 2 groups of 30 each. Placebo group (Group P) received 20 mL normal saline intravenously and Clonidine group (Group C) received 2.5 micrograms Clonidine per kilogram body weight in 20 mL saline intravenously 20 mins before surgery. Haemodynamic variability during surgery, intraoperative inhalational agent requirement and perioperative bleeding as assessed by surgeon, postoperative analgesic requirement and post-operative shivering were compared between two groups. RESULTSThere was statistically significant reduction in heart rate, systolic blood pressure, diastolic blood pressure and mean blood pressure in Group C compared to Group P. There was statistically significant decrease in requirement of Isoflurane, decreased bleeding from surgical site, decreased analgesic consumption and nil incidence of postoperative shivering in Group C compared to Group P. CONCLUSIONClonidine is an ideal agent for hypotensive anaesthesia as it has got other favourable effects along with controlled hypotension, as it was observed in this study.

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“…So we decided to compare oral clonidine and oral atenolol as premedication, as both of them posses nearly similar pharmacokinetic and pharmacodynamic profile. We compare these two drugs as oral premedication, because hypotension and bradycardia are major adverse effects of intravenous administration of clonidine and beta blockers as compared with oral premedication, so oral premedication is considered as safe option [3,4] . Clonidine is a centrally acting selective alpha 2 adrenergic agonist with alpha 2 : alpha 1 activity 200:1.…”

Section: Discussionmentioning

confidence: 99%

“…So we designed the present study to compare the effects of oral premedication with tablet clonidine and tablet atenolol by as both of them posses nearly similar pharmacokinetic and pharmacodynamic profile. Oral route is www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 71.58 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i11.183 considered as safe option, because hypotension and bradycardia are major adverse effects with intravenous administration of clonidine and beta blockers [3,4] . So, we decided to compare clonidine and atenolol as oral premedication for functional endoscopic sinus surgery and study their merits and demerits.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Oral Clonidine and Oral Atenolol as Premedication in Functional Endoscopic Sinus Surgery (FESS) Under General Anaesthesia

Patil¹

2017

jmscr

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Effects of Clonidine on Anesthetic Drug Requirements and Hemodynamic Response during Aortic Surgery

Cited by 165 publications

References 0 publications

Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section

Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section

Clonidine Premedication as a Desirable Part of Hypotensive Anaesthesia for Functional Endoscopic Sinus Surgery

Comparative Evaluation of Oral Clonidine and Oral Atenolol as Premedication in Functional Endoscopic Sinus Surgery (FESS) Under General Anaesthesia

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