Effects of Clozapine (Leponex^®) On Sleep Patterns in the Cat

Abstract

1 figure)This study examined the effects of clozapine on sleep-wakefulness profile in cats prepared for chronic recording of sleep. Clozapine in single dose (Lp.) of 5 mg/kg drastically reduced slow-wave sleep (SWS) and paradoxical sleep (PS), while wakefulness and drowsy pattern were increased. These changes lasted approximately 24 h and were followed by sleep recovery. PS had a priority of recovery. Some similarities between clozapine effects on sleep in cat and human were mentioned. Archives of Physiology and Biochemistry Downloaded from informahealthcare.com by McMaster University on 12/03/14 For personal use only. physiology, Endocrinology, Episodes, Dreams, Epilepsy and Intracranial Pathology (LEVIN, P. & KOELLA, W. P., eds) p. 31 1-315. Karger, Basel. Brit. J. Pharmacol. 46, 736-140. SUSIC, V. & KOVAEEVI~, R. (1974) Brain Res. 65, 427-441. Veselinka SUSIC Fiziolski Institut Medicinskog Fakulteta 26, ViSegradska, 1 1O00, Beograd, Jugoslavija Archives of Physiology and Biochemistry Downloaded from informahealthcare.com by McMaster University on 12/03/14 For personal use only.