Effects of coenzyme Q₁₀on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

Abstract

The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ10/kg BW with LPS (LCQI) and 300 mg of CoQ10/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ10 to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ10 to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ10 unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ10 exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats.

The effects of coenzyme Q10 supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet

“…The body weight gain and relative weights of the liver and abdominal fat were not influenced by the CoQ 10 supplement. These results were in agreement with the previous study [8], which reported that the CoQ 10 did not affect animal performance and organ weights in the SD rats. As expected, it is well known that high-cholesterol diet can increase in the weights of body, liver and abdominal fat pads, as well as blood cholesterol and triglyceride levels [23,24].…”

“…Numerous studies have demonstrated that dietary CoQ 10 supplement significantly alleviates various degenerative diseases and toxicity via activating the antioxidant defense system in human and rodents [1,6,7]. In particular, dietary supplementation with CoQ 10 has been recommended to improve clinical and metabolic disorder for cardiovascular disease, especially in abnormal conditions such as ageing and oxidative stress [3,8]. Especially because of the vital role of CoQ 10 in antioxidant defense system, it has been suggested that dietary CoQ 10 may protect against oxidative damage induced by reactive oxygen species (ROS), which is produced under certain physiological conditions [6,9].…”

The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

“…Thus, there is still a lack of evidence about whether the administration of CoQ10 to animals during oxidative stress can affect the antioxidant system, despite the rather well recognized antioxidant effects of CoQ10 in vitro. 21 In the above context, the aim of this study was designed to examine the effects of dietary CoQ10 on blood biochemical profiles, the histopathological changes in lungs of adult rats exposed to early cyclophosphamideinduced lung toxicity.…”

AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells

“…qRT-PCR was performed as previously described 52 . Briefly, total RNA was extracted using TRIzol reagent (Ambion) and converted to complementary DNA using M-MLV reverse transcriptase (Promega, Madison, WI, USA) according to the manufacturer’s instructions.…”