Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Iriondo‐DeHond, Amaia; Uranga, José Antonio; Castillo, María Dolores del; Abalo, Raquel

doi:10.3390/nu13010088

Cited by 83 publications

(59 citation statements)

References 236 publications

(293 reference statements)

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“…The copyright holder for this this version posted December 30, 2021. ; https://doi.org/10.1101/2021.12.23.21268179 doi: medRxiv preprint metabolism of these bacteria. Of note, coffee is rich in antioxidants 29 and affects gut motility, which could also affect the sampling and the bacterial community 30 . In summary, we report novel association of previously reported coffee biomarkers with the abundance in the gut microflora with a set of bacteria from the Eubacteriales order and with Streptococcus saliviarus.…”

Section: (Which Was Not Certified By Peer Review) Preprintmentioning

confidence: 99%

An online atlas of human plasma metabolite signatures of gut microbiome composition

Dekkers

Sayols-Baixeras

Baldanzi

et al. 2021

Preprint

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The human gut microbiota produces a variety of small compounds, some of which enter the bloodstream and impact host health. Conversely, various exogenous nutritional and pharmaceutical compounds affect the gut microbiome composition before entering circulation. Characterization of the gut microbiota—host plasma metabolite interactions is an important step towards understanding the effects of the gut microbiota on human health. However, studies involving large and deeply phenotyped cohorts that would reveal such meaningful interactions are scarce. Here, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for detailed characterization of the fecal microbiota and plasma metabolome, respectively, of 8,584 participants invited at age 50 to 64 of the Swedish CArdioPulmonary bioImage Study (SCAPIS). After adjusting for multiple comparisons, we identified 1,008 associations between species alpha diversity and plasma metabolites, and 318,944 associations between specific gut metagenomic species and plasma metabolites. The gut microbiota explained up to 50% of the variance of individual plasma metabolites (mean of 4.7%). We present all results as the searchable association atlas "GUTSY" as a rich resource for mining associations, and exemplify the potential of the atlas by presenting novel associations between oral medication and the gut microbiome, and microbiota species strongly associated with levels of the uremic toxin p-cresol sulfate. The association atlas can be used as the basis for targeted studies of perturbation of specific bacteria and for identification of candidate plasma biomarkers of gut flora composition.

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Section: (Which Was Not Certified By Peer Review) Preprintmentioning

confidence: 99%

An online atlas of human plasma metabolite signatures of gut microbiome composition

Dekkers

Sayols-Baixeras

Baldanzi

et al. 2021

Preprint

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“…As one of the most popular and consumed beverage in the world, coffee is constantly a subject of scientific study, namely for the identification of the compounds responsible for coffee consumption associated health effects [1][2][3][4][5][6][7][8][9]. One theme of great importance on coffee consumption is its relation to the inflammation process as coffee contains multiple substances that individually are known to impact inflammatory markers [10].…”

Section: Introductionmentioning

confidence: 99%

Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects

Passos

Costa

Ferreira

et al. 2021

Foods

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Coffee brews have High Molecular Weight (HMW) compounds with described immunostimulatory activity, namely polysaccharides and melanoidins. Melanoidins are formed during roasting and are modified during brews technological processing. In addition, brews have Low Molecular Weight (LMW) compounds, namely free chlorogenic acids and caffeine, with well-known anti-inflammatory properties. However, this study shows that both espresso and instant coffee brews did not present immunostimulatory neither anti-inflammatory in vitro activities. It is possible that the simultaneous existence of compounds with antagonistic effects can mitigate their individual effects. To test this hypothesis, an ultrafiltration separation process was applied, studying the behavior of coffee brews’ HMW on retention of LMW compounds. Several ultrafiltration sequential cycles were required to separate retentates from LMW compounds, suggesting their retention. This effect was higher in instant coffee, attributed to its initial higher carbohydrate content when compared to espresso. Separation of HMW and LMW compounds boosted their immunostimulatory (6.2–7.8 µM nitrites) and anti-inflammatory (LPS induced nitrite production decrease by 36–31%) in vitro activities, respectively. As coffee anti-inflammatory compounds are expected to be first absorbed during digestion, a potential in vivo fractionation of LMW and HMW compounds can promote health relevant effects after coffee intake.

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“…Moreover, a coffee intake of ≥2 cups/day was shown to be significantly associated with lower Aβ accumulation when compared with a coffee intake of <2 cups/day, even after controlling for potential confounders [ 259 ]. As recently reviewed, coffee and its components may exert multiple effects on the digestive tract, including antioxidant and anti-inflammatory actions, which in turn can influence the health and functioning of the gut-brain axis [ 260 ].…”

Section: Prevention Of Cognitive Decline Through Nutritional Interventionsmentioning

confidence: 99%

In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function

Melzer

Manosso

Yau

et al. 2021

IJMS

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Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and fish may reduce age-related cognitive decline and the risk of developing various neurodegenerative diseases. Numerous studies have been published over the last decade focusing on nutrition and how this impacts health. The main objective of the current article is to review the data linking the role of diet and nutrition with aging and age-related cognitive decline. Specifically, we discuss the roles of micronutrients and macronutrients and provide an overview of how the gut microbiota-gut-brain axis and nutrition impact brain function in general and cognitive processes in particular during aging. We propose that dietary interventions designed to optimize the levels of macro and micronutrients and maximize the functioning of the microbiota-gut-brain axis can be of therapeutic value for improving cognitive functioning, particularly during aging.

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Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Cited by 83 publications

References 236 publications

An online atlas of human plasma metabolite signatures of gut microbiome composition

An online atlas of human plasma metabolite signatures of gut microbiome composition

Role of Coffee Caffeine and Chlorogenic Acids Adsorption to Polysaccharides with Impact on Brew Immunomodulation Effects

In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function

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