Effects of Coffee Consumption on Oxidative Susceptibility of Low-Density Lipoproteins and Serum Lipid Levels in Humans

Abstract

Since little is known about how coffee intake affects low-density lipoprotein (LDL) oxidative susceptibility and serum lipid levels, we conducted an in vivo study in 11 healthy male students of Wakayama Medical University aged between 20 and 31 years fed an average Japanese diet. On days 1-7 of the study, the subjects drank mineral water. On day 7, the subjects began drinking coffee, 24 g total per day, for one week. This was followed by a one week "washout period" during which mineral water was consumed. Fasting peripheral venous blood samples were taken at the end of each one-week period. LDL oxidation lag time was approximately 8% greater (p < 0.01) after the coffee drinking period than the other periods. Serum levels of total cholesterol and LDL-cholesterol (LDL-C) and malondialdehyde (MDA) as thiobarbituric acid reactive substances (TBARS) were significantly decreased after the coffee drinking period. Finally, regular coffee ingestion may favorably affect cardiovascular risk status by modestly reducing LDL oxidation susceptibility and decreasing LDL-cholesterol and MDA levels.

Consumo de café segundo métodos de preparo da bebida e associação com perfil lipídico sérico em hipertensos e diabéticos

“…Nardini et al 45 encontraram aumento significativo na resistência da LDL à oxidação, associado à incorporação dos ácidos cafeico, ferúlico e p-cumárico à LDL, 30 a 60 minutos após o consumo de 200 mL da bebida café (12g de pó), sendo o resultado mais expressivo observado após 60 minutos. Um resultado similar foi encontrado com a ingestão de 450mL de café (24g de pó) durante 7 dias de estudo, verificando-se uma diminuição significativa da oxidação lipídica 46 .…”

Does coffee consumption alter plasma lipoprotein(a) concentrations? A systematic review

“…There were no differences between serum Lp(a) concentrations at the end of the baseline period (25.1± 16.2 mg/dL), the end of the coffee consumption period (23.2 ± 11.4 mg/dL), and the washout period (23.7 ± 13.9 mg mg/dL) (Yukawa et al 2004). It is likely that this trial was underpowered to detect differences in Lp(a) over the time period employed, however, statistically significant decreases in TC and LDL-C were observed (Yukawa et al 2004). The authors suggested that the relatively high dose of coffee used in this study (150 ml three times a day) may explain the fact that opposite effects of coffee on TC and LDL-C were seen here, compared to other studies (Yukawa et al 2004).…”

“…An initial screen of titles and abstracts was performed in order to remove articles, which were clearly irrelevant. After reading the full-texts of the remaining 121 papers, we identified 6 relevant papers (Urgert et al 1996, Urgert et al 1997, Strandhagen et al 2003, Yukawa et al 2004, Bukowska et al 2006, Correa et al 2013.…”

“…The study aimed to investigate the effects of coffee on lipid metabolism and the oxidative modification of LDL-C. There were no differences between serum Lp(a) concentrations at the end of the baseline period (25.1± 16.2 mg/dL), the end of the coffee consumption period (23.2 ± 11.4 mg/dL), and the washout period (23.7 ± 13.9 mg mg/dL) (Yukawa et al 2004). It is likely that this trial was underpowered to detect differences in Lp(a) over the time period employed, however, statistically significant decreases in TC and LDL-C were observed (Yukawa et al 2004).…”

“…Yukawa conducted a study in 11 healthy male students in which participants drank 150 ml coffee three times per day for a week, preceded and followed by abstinence periods in which they drank only mineral water (Yukawa et al 2004). The study aimed to investigate the effects of coffee on lipid metabolism and the oxidative modification of LDL-C.…”