Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

Chen, Zhitong; Lin, Li; Cheng, Xiaoqian; Gjika, Eda; Keidar, Michael

doi:10.1002/ppap.201600086

Cited by 53 publications

(41 citation statements)

References 31 publications

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“…In Ar bubble discharge,

N {normalO}_{2}^{-}

and

N {normalO}_{3}^{-}

also can be generated resulting from the dissolved air in deionized water . In gas phase and gas‐liquid interface, HNO 2 and HNO 3 can be originated from reactions of NO radicals with other molecules (R16‐R19), and then dissolved in water with high Henry's law constants (1.15 × 10 3 and 4.8 × 10 6 , respectively) .…”

Section: Resultsmentioning

confidence: 99%

Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a

Zhou

Wang

Yang

et al. 2018

Plasma Processes & Polymers

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An underwater Ar bubble discharge is excited by nanosecond pulsed power, and the effects of adding N2/O2 in Ar discharge on products are investigated. This work focus on regulating species concentration in plasma activated water (PAW), and then seeking specific concentrations for future application. The optical emission spectra (OES) and colorimetric chemical probes are used to diagnose and measure active species in plasma region or liquid phase. The H2O2 energy yield with Ar bubble can be up to 3.04 g kWh−1. The emission intensity characteristics of Ar (4p‐4s), OH (A‐X), Hα, and O (3p‐3s) in plasma region, and the concentrations of H2O2, NnormalO3−, and NnormalO2− in liquid are investigated with adding varying N2/O2 proportion in Ar bubble discharge.

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“…In Ar bubble discharge,

N {normalO}_{2}^{-}

and

N {normalO}_{3}^{-}

Section: Resultsmentioning

confidence: 99%

Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a

Zhou

Wang

Yang

et al. 2018

Plasma Processes & Polymers

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“…The accumulation of nitrates and nitrites is a concern due to induced changes in cell viability (Tresp, Hammer, Weltmann, & Reuter, ). Furthermore, ROS and RNS detected in PAW treated with helium gas plasma have resulted in significant effects on the rate of apoptosis (Chen, Lin, Cheng, Gjika, & Keidar, ), while H 2 O 2 and O 2 − produced have led to generation of OH• in cells via the Haber‐Weiss reaction, which resulted in apoptosis and cell death (Xu et al., ).…”

Section: Effect Of Ntp Species and Their Toxicitymentioning

confidence: 99%

Effects of Nonthermal Plasma Technology on Functional Food Components

Muhammad

Liao

Cullen

et al. 2018

Comp Rev Food Sci Food Safe

104

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Understanding the impact of nonthermal plasma (NTP) technology on key nutritional and functional food components is of paramount importance for the successful adoption of the technology by industry. NTP technology (NTPT) has demonstrated marked antimicrobial efficacies with good retention of important physical, chemical, sensory, and nutritional parameters for an array of food products. This paper presents the influence of NTPT on selected functional food components with a focus on low-molecular-weight bioactive compounds and vitamins. We discuss the mechanisms of bioactive compound alteration by plasma-reactive species and classify their influence on vitamins and their antioxidant capacities. The impact of NTP on specific bioactive compounds depends both on plasma properties and the food matrix. Induced changes are mainly associated with oxidative degradation and cleavage of double bonds in organic compounds. The effects reported to date are mainly time-dependent increases in the concentrations of polyphenols, vitamin C, or increases in antioxidant activity. Also, improvement in the extraction efficiency of polyphenols is observed. The review highlights future research needs regarding the complex mechanisms of interaction with plasma species. NTP is a novel technology that can both negatively and positively affect the functional components in food.

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“…After 24h incubation at 37 ˚C (19), MTT solution was added into each well and the plates were then incubated for 3 to 4 hours at 37 ˚C. After incubation, the solution was removed and 1 ml DMSO (Dimethyl sulfoxide) was added to cells in order to dissolve crystals.…”

Section: Mtt Assaymentioning

confidence: 99%

Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells

2017

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Cold atmospheric plasma (CAP) has received great attention due to its noteworthy ability, and has also been widely studied over few decades in physics, biology and medicine. The purpose of this study is to evaluate the cold atmospheric pressure plasma effects on the proliferation of breast cancer cells. MDA-MB-231 was used for this experiment. MDA-MB-231 cells were cultured in 24-well plate and treated with non-thermal plasma. The viability of the cancer cells was determined by MTT assay. Different input power was applied in this experience (20-35W), and treatment time was between 5s and 25s. For reducing thermal damage, gas temperature was less than 37 ˚C. The Viability of breast cancer cells was significantly decreased after plasma treatment. The results showed that viability was decreased with an increment of plasma power and plasma exposure time. These results suggest that non-thermal atmospheric pressure plasma could strongly have cytotoxicity effect on cancerous breast cell.

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Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

Cited by 53 publications

References 31 publications

Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a

Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a

Effects of Nonthermal Plasma Technology on Functional Food Components

Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells

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Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

Cited by 53 publications

References 31 publications

Controlling of reactive species in atmospheric Ar bubble discharge by adding N2/O2a

Controlling of reactive species in atmospheric Ar bubble discharge by adding N2/O2a

Effects of Nonthermal Plasma Technology on Functional Food Components

Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells

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Product

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Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a

Controlling of reactive species in atmospheric Ar bubble discharge by adding N₂/O₂^a