Effects of Cold-Induced Vasospasm in Glaucoma: The Role of Endothelin-1

Nicolela, Marcelo T.; Ferrier, Suzanne; Morrison, Christine; Archibald, Michele L.; LeVatte, Terry L.; Wallace, Karin; Chauhan, Balwantray C.; LeBlanc, Raymond P.

doi:10.1167/iovs.02-0913

Cited by 118 publications

(95 citation statements)

References 40 publications

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“…Kunimatsu et al [25] found a higher ET-1 plasma level in patients with POAG as compared to the control group (1.33 § 0.50 pg/mL), but with no statistical significance, unlike our results (Table 4). In 1997, Tezel et al [14] and, in 2003, Nicolela et al [9] also did not find significant differences in the EG-1 plasma concentration between healthy and POAG patients as well (Table 4). …”

Section: Resultsmentioning

confidence: 89%

“…Increased levels of ET-1 are found in acute renal failure, hypertension, heart failure, ischemic heart disease, Prinzmetal angina, pulmonary hypertension, Raynaud's disease, subarachnoid hemorrhage, cerebral vasospasm, migraine and diabetes [5,9]. EG-1 is normally found in the eye, where it is produced by the non-pigmented ciliary epithelium and is released into the intraocular liquid [10].…”

Section: Introductionmentioning

confidence: 99%

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Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Mihaylova

Petkova

Rankova-Yotova

et al. 2017

Biotechnology & Biotechnological Equipment

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Endothelin-1 (ET-1) is a potent vasoconstrictor and is considered to have a key role in the regulation of ocular perfusion and glaucoma pathogenesis. High ET-1 and ET A -receptor levels are reported in patients with primary open-angle glaucoma (POAG). We compared the mean plasma ET-1 and ET Areceptor concentration of controls and patients with early and advanced POAG stage, and assessed the correlation with the retinal nerve fibre layer (RNFL) thickness. The study included a total of 75 participants, aged 45-83 years: 25 (controls), 22 (early glaucoma) and 28 (advanced glaucoma). The plasma concentration of ET-1 and ET A -receptor was determined by enzyme-linked immunosorbent assay. The RNFL thickness was evaluated with spectral-domain optical coherence tomography. The mean ET-1 concentration was lower in the control group (4.88 § 1.75 pg/mL) than in the early and advanced POAG group (6.33 § 2.38 and 6.34 § 1.56 pg/mL). Statistically significant difference was found between the mean ET-1 concentrations in controls and glaucoma patients (p = 0.029 -early glaucoma, p = 0.018 -advanced glaucoma), and no significant difference was observed between the two POAG groups (p = 0.998). The mean ET A -receptor concentration was highest in the control group (1209.28 § 314.48 pg/mL) and the differences between the three groups were significant. Significant relationship was found only between ET-1 and RNFL. This study demonstrated the role of ET-1 in glaucoma pathogenesis based on the observed significant high ET-1 and ET A -receptor plasma levels in POAG patients. A new therapeutical approach needs to be considered in some patients.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Mihaylova

Petkova

Rankova-Yotova

et al. 2017

Biotechnology & Biotechnological Equipment

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“…In fact, previous studies demonstrated that patients with glaucoma, in contrast to the control subjects, have an abnormal hyperactivity of ET-1 in response to vasospastic stimuli such as cold. 58 It has been postulated that an imbalance between vasoconstrictor substances such as 59,60 It was reported that patients with glaucoma who have vasospasm have a higher susceptibility to glaucomatous damage, which could be a consequence of a decreased dilation of blood vessels that properly autoregulate blood flow. 55 If our speculation is correct, BCACs induce normalization of ET-1, and its receptor balance may be beneficial for ocular blood circulation, since an increased ET-1 reactivity could lead to decreased ocular blood flow as indicated above.…”

Section: Discussionmentioning

confidence: 99%

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida

Ohguro

2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Our recent study, which involved a randomized, placebo-controlled, double-masked 24-month trial (Ophthalmologica 2012;228:26-35), revealed that oral administration of black currant anthocyanins (BCACs) slowed down the visual field deterioration and elevation of ocular blood flow of open-angle glaucoma (OAG). To elucidate the underlying mechanisms of these BCAC-induced effects, as possible factors affecting glaucomatous optic neuropathy, changes of serum endothelin-1 (ET-1), nitric oxide (NO), and antioxidative activities were examined in the present study. Methods: From among patients with OAG who participated in the randomized, placebo-controlled, doublemasked trial, serum specimens were obtained from BCAC-treated (n = 19) or placebo-treated (n = 19) patients at baseline and every 6 months. Healthy volunteers (n = 20) with age and gender matching the patients were used as a control. Serum ET-1 concentration, [NO 2 -] and [NO 2 -+ NO 3 -] levels, advanced oxidation protein products (AOPP), and antioxidant activities were measured by using commercially available kits. Results: At the trial baseline, serum ET-1 concentrations were significantly lower in patients with OAG (BCACs, 3.18 -1.06 pg/mL; placebo, 3.44 -0.84 pg/mL) than those in healthy volunteers (4.38 -1.03 pg/mL) (one-way analysis of variance and a Tukey's multiple comparison post hoc test, P < 0.05). Upon administration of BCACs, serum ET-1 concentrations increased to the levels of those in healthy volunteers during the 24-month period. In contrast, those of placebo-treated patients remained at lower levels (3.82 -1.14 pg/mL). While [NO 2 -] and [NO 2 -+ NO 3 -] levels, AOPP, and antioxidative activities of patients from both the BCACs and placebo groups showed comparable levels to those of healthy subjects at baseline, no significant changes were observed during the observational period in either the BCAC or placebo groups. Conclusions: Among the possible beneficial effects of BCACs toward visual field progression in patients with OAG, our present results suggest that BCACs caused normalization of serum ET-1 levels, and this may modulate ET-1-dependent regulation of the ocular blood hemodynamics.

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“…33,[40][41][42][43] These apparent alterations in the circulation of the glaucomatous optic nerve may implicate dysfunction of vascular regulatory mechanisms. Further support for vascular dysregulation has been suggested by the finding of elevation of ET-1, a potent vasoconstricting peptide, in the plasma 39,[44][45][46] and aqueous humor 47,48 of patients with glaucoma. In the optic nerve, evidence of decreased blood flow correlating with visual field damage has been reported in glaucoma patients.…”

Section: Glaucoma and Systemic Vascular Diseasementioning

confidence: 98%

Ischemic model of optic nerve injury

Cioffi

2006

American Journal of Ophthalmology

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Effects of Cold-Induced Vasospasm in Glaucoma: The Role of Endothelin-1

Abstract: Patients with glaucoma have an abnormal increase in plasma ET-1 after the body cools. It is possible that at least in some patients, increased levels of ET-1 in response to vasospastic stimuli may be involved in the pathogenesis of glaucomatous damage.

Cited by 118 publications

References 40 publications

Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Ischemic model of optic nerve injury

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