Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials

Abstract

Previous studies have advocated that collagen peptide supplementation (CPS) can positively affect cardiovascular health. However, the widespread impact of CPS on cardiovascular disease-related markers is not fully resolved. Consequently, the current systematic review and meta-analysis aimed to assess the efficacy of CPS on cardiovascular disease-related markers. A systematic search in the Scopus, PubMed, and ISI Web of Science databases were completed to identify relevant randomized, placebo-controlled trials (RCTs) published up to November 2021. Mean Differences were pooled using a random-effects model, while publication bias, sensitivity analyses, and heterogeneity were assessed using previously validated methods. Twelve RCTs, comprising of a total of eleven measured markers, were selected for the quantitative analysis. Pooled data revealed that CPS significantly decreased fat mass (-1.21 kg; 95% CI: -2.13, -0.29; I2 = 0.0%; p = 0.010), and increased fat-free mass, based on body mass percentage (1.49 %; 95% CI: 0.57, 2.42; I2= 0.0%; p = 0.002). Moreover, collagen peptide supplementation led to a significant decrease in serum low-density lipoprotein (-4.09 mg/dl; 95% CI: -8.13, -0.04; I2 = 93.4%; p = 0.048) and systolic blood pressure (-5.04 mmHg; 95 % CI: -9.22, -0.85; I2 = 98.9%; p = 0.018). Our analysis also indicated that CPS did not affect glycemic markers. Our outcomes indicate that CPS reduces fat mass, low-density lipoprotein, and systolic blood pressure while increasing fat-free mass. Future investigations with longer CPS duration are needed to expand on our results.

Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

“…In line with the findings of two systematic reviews [39,52], significant favorable body composition changes have been observed following several weeks of consuming CP together with either resistance (RT) or concurrent (CT) training with a moderate certainty of evidence. Furthermore, the current meta-analysis demonstrated enhanced fat-free mass (FFM) along with muscle architectural adaptations, expressed as augmentations in one-, two-, and three-dimensional measurements.…”