“…All had been reported in published form. In response to inquiries seeking morbidity data absent from the published reports, the investigators of 12 trials furnished unpublished data (34,36,47,49,60,65,66,71,72,74,92,96).…”
Albumin reduces morbidity in acutely ill hospitalized patients. Concomitant administration of albumin in the control group can obscure the effects of albumin on clinical outcome in randomized trials.
“…All had been reported in published form. In response to inquiries seeking morbidity data absent from the published reports, the investigators of 12 trials furnished unpublished data (34,36,47,49,60,65,66,71,72,74,92,96).…”
Albumin reduces morbidity in acutely ill hospitalized patients. Concomitant administration of albumin in the control group can obscure the effects of albumin on clinical outcome in randomized trials.
“…In another study Gallagher, Moore et al confLrmed that EVLW does not change during coronary artery bypass grafting as long as PCWP is maintained less than 14 mmHg in spite of different types of intravenous fluid administration. 17 Shires et al compared the effects of crystalloid versus colloid infusion in patients undergoing abdominal aortic surgery, 's in whom the PCWP was kept within 2 mmHg of preoperative levels. No change was found in EVLW immediately after surgery in both groups compared with the preoperative measurements.…”
“…This could thus affect the contribution of infusion fluids to pulmonary edema formation. Indeed, researchers have documented an increase in extravascular lung water (EVLW) after cardiac or major vascular surgery and fluid loading, at least transiently in some patients 57–59,67–70. Verheij et al71 hypothesized that colloid fluid loading would aggravate less edema formation in the lungs than saline loading in the treatment of presumed hypovolemia after major surgery, even if complicated by increased pulmonary permeability.…”
Section: Pulmonary Mechanics: Comparison Of Hes 130/04 and Other Fluidsmentioning
ObjectivesRestoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery.Material and methodsA subjective, not systematic, review of literature was performed. Papers were searched to answer questions about efficacy of HES, its impact on coagulation and inflammation and its effects on pulmonary mechanics and renal function.ConclusionsHES 130/0.4 is effective for volume therapy and is less expensive than human albumin. Its effects on coagulation and renal function are manageable; it may ameliorate pulmonary permeability and reduce inflammation.
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