Effects of Combination Therapy with Bunium persicum and Foeniculum vulgare Extracts on Patients with Polycystic Ovary Syndrome

Mohammadi, Belgheis; Aliakbari, Fatemeh; Mirsadeghi, Misa Naghdipour; Hashemi, Elmira; Amini‐Khoei, Hossein

doi:10.4103/abr.abr_163_21

Cited by 4 publications

(7 citation statements)

References 21 publications

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“…Based on the results of numerous articles, black caraway has antioxidant, hypoglycemic, weight-reducing, antihypertensive, and antidyslipidemic properties. Possible mechanisms include (1) the reduction of ghrelin (appetite-stimulating hormone); (2) the reduction of production of visceral fat and, thereby lowering pro-inflammatory cytokines produced in these tissues (by carvacrol) (28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial

et al. 2023

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Background: The prevalence of obesity has almost tripled since 1975, and obesity places a heavy economic burden on healthcare systems. There is a high tendency to use a variety of complementary medicine modalities for weight management among obese patients. Persian Medicine is an ancient medical school practiced for thousands of years in Iran. Found in reliable Iranian traditional resources, Komouni formulation (KF) is a compound medicine that can be effective in the treatment of obesity. It comprises black caraway (Bunium persicum Boiss.), anise (Pimpinella anisum L.), fennel (Foeniculum vulgare Miller), and ajwain (Trachyspemum ammi L.) Objectives: This study aimed to determine the effects of KF on anthropometric indices and metabolic parameters in overweight and obese women. Methods: This triple-blinded randomized controlled clinical trial was performed on 70 overweight or obese women aged 20 - 40 years, with a body mass index (BMI) of 25 - 34.9 kg/m2. The subjects were randomly divided into two groups (each group n = 35) to receive a calorie-restricted diet with 2 g/day (500 mg 30 minutes before breakfast, 1000 mg 30 minutes before lunch, and 500 mg 30 minutes before dinner) KF or placebo for 8 weeks. Anthropometric indices, food intake, and biochemical parameters were measured at baseline and after the intervention. Results: A total of 60 women (intervention = 30; placebo = 30) completed the trial. After the intervention, the KF group experienced a significant reduction in weight (-4.8 vs. -3.2 kg; P = 0.0001), BMI (-1.8 vs. -0.79 kg/m2; P = 0.0001), waist circumference (-5.28 vs. -3.20 cm; P = 0.004), hip circumference (-0.018 vs. -0.008 cm; P = 0.047), fasting blood sugar (-5.6 vs. 0.33; P = 0.025), and low-density lipoprotein (-11.7 vs. 6.7; P = 0.0001), compared to the placebo group. None of the patients in the intervention and placebo groups reported any side effects. Conclusions: Using KF, along with a calorie-restricted diet, can reduce cardiometabolic risk factors in overweight and obese women. However, further studies are needed to elucidate the efficacy of KF as a complementary therapy in obesity.

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Section: Discussionmentioning

confidence: 99%

Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial

et al. 2023

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“…Several studies reported that the testosterone level increased after receiving treatment [38,39,41,47,48]. Tumors have the potential to overproduce androgens, resulting in increased testosterone levels.…”

Section: Testosteronementioning

confidence: 99%

“…Progesterone, the synthesis of which depends on the corpus luteum, regulates reproductive cycles and assists the uterus in implantation during conception [74]. Progesterone levels significantly increased after treatment in several studies [39][40][41]46], and significantly decreased in another study [50,51]. Phytoestrogens contain compounds that mimic or interact with estrogen in the body.…”

Section: Progesteronementioning

confidence: 99%

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Exploring the Therapeutic Potential of Natural Products in Polycystic Ovarian Syndrome (PCOS): A Mini-Review of Lipid Profile, Blood Glucose, and Ovarian Histological Improvements

Wahid,

Ramli,

Fazleen

et al. 2024

Life

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is characterized by fluid-filled sacs in the ovaries and various symptoms, including high androgen levels, endometrial irregularities, and cysts. Although the main cause of PCOS remains unknown, it has been linked to genetic, endocrine, and metabolic factors, and there are several treatment options, including lifestyle modifications, medications, and surgery. Natural products such as medicinal plants and fruits are being explored as potential treatments for PCOS because of their bioactive compounds with pharmacological effects related to antioxidant, antimicrobial, anticancer, and antidiabetic properties. Some of these compounds improve insulin sensitivity, reduce inflammation, and enhance glucose metabolism, thereby benefiting patients with PCOS. This mini-review examined the effects of natural products on PCOS, including their effects on ovarian histological changes, blood glucose, sex hormones, and lipid profiles, based on animal and human studies. This study suggests that the use of natural products as complementary medicines can be a promising resource for the development of effective therapeutics for PCOS; however, further research is needed to fully understand their benefits.

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“…Fennel has undergone extensive research revealing its numerous benefits, which encompass antimicrobial, antifungal, anti-inflammatory, antioxidant, anxiolytic, cardioprotective, and potential hormonal properties [13]. Notably, fennel acetone extract shows promise in menstrual cycle regulation [14], and it may affect hormone levels by increasing the follicle-stimulating hormone while decreasing the luteinizing hormone and testosterone [15]. Moreover, fennel essential oils notably influence oocyte maturation and sexual maturity in fishes [16,17].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Effects of Fennel (Foeniculum vulgare) Seed Essential Oil as a Diet Supplement on the Biochemical Parameters and Reproductive Function in Female Common Carps (Cyprinus carpio)

Ahmadniaye Motlagh,

Horie,

Rashid

et al. 2023

Water

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The present study aimed to investigate the effect of Foeniculum vulgare essential oil on the health of the common carp (Cyprinus carpio). A total of 120 healthy fish were provided with feed containing 200, 400, and 600 mg/kg of F. vulgare oil for 60 days. Findings revealed that the oral administration of 200 mg/kg of F. vulgare oil significantly increased final weight, weight gain, and specific growth rate compared to the control group (p < 0.05). Plasma biochemical enzyme levels remained unchanged in 200 and 400 mg/kg treatments, whereas they were found to be significantly increased in treatments with 600 mg/kg. Although no significant alterations in glucose, triglyceride, and cholesterol levels were observed, the treated groups exhibited significant increases in total protein, albumin, globulin, and creatinine levels. Results also indicated significantly decreasing levels of glutathione peroxidase, whereas superoxide dismutase activity increased. The gonadosomatic index showed notable improvement in the 200 and 400 mg/kg groups. Furthermore, plasma concentrations of estradiol and testosterone were significantly affected by doses of 400 and 200 mg/kg. Findings suggest that, following the administration of F. vulgare extract, the reproductive and general health of the fish appears to be improved. Nevertheless, it is recommended to supplement fish diets with up to 200 mg/kg of F. vulgare extract to improve their reproductive and general health. Concentrations above this limit can potentially cause harm.

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Effects of Combination Therapy with Bunium persicum and Foeniculum vulgare Extracts on Patients with Polycystic Ovary Syndrome

Cited by 4 publications

References 21 publications

Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial

Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial

Exploring the Therapeutic Potential of Natural Products in Polycystic Ovarian Syndrome (PCOS): A Mini-Review of Lipid Profile, Blood Glucose, and Ovarian Histological Improvements

Unveiling the Effects of Fennel (Foeniculum vulgare) Seed Essential Oil as a Diet Supplement on the Biochemical Parameters and Reproductive Function in Female Common Carps (Cyprinus carpio)

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