Effects of combined administration of vasopressin, epinephrine, and norepinephrine during cardiopulmonary resuscitation in pigs*

Prengel, Andreas W.; Linstedt, Ulf; Zenz, M.; Wenzel, Volker

doi:10.1097/01.ccm.0000186774.30674.15

Cited by 25 publications

(25 citation statements)

References 33 publications

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“…This trigger for FFP is widely accepted (or implicit) in guidelines (16). They identified patients in whom an international normalized ratio of Ն1.5 was found during intensive care unit stay and evaluated FFP use in this subgroup for patients who were not actively bleeding.…”

Section: Was Sick and You Cared For Me-matthew 25:36mentioning

confidence: 99%

Fresh frozen plasma: Friend or faux pas in critical illness?*

Stanworth

Walsh

2005

Critical Care Medicine

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Section: Was Sick and You Cared For Me-matthew 25:36mentioning

confidence: 99%

Fresh frozen plasma: Friend or faux pas in critical illness?*

Stanworth

Walsh

2005

Critical Care Medicine

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“…[1][2][3] Animal studies, in contrast, have demonstrated superior survival rates with drug use. [4][5][6][7][8][9][10][11][12][13] One reason for failure of animal studies to translate to clinical practice may be the time at which the first drug is delivered. Previous work has demonstrated the average time to first drug administration in clinical trials is 19.4 minutes (range 13.3-25.0; 95% CI around the mean 12.8, 25.9).…”

Section: Introductionmentioning

confidence: 99%

Drug administration in animal studies of cardiac arrest does not reflect human clinical experience

2007

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Introduction-To date, there is no evidence showing a benefit from any advanced cardiac life support (ACLS) medication in out-of-hospital cardiac arrest (OOHCA), despite animal data to the contrary. One explanation may be a difference in the time to first drug administration. Our previous work has shown the mean time to first drug administration in clinical trials is 19.4 minutes. We hypothesized that the average time to drug administration in large animal experiments occurs earlier than in OOHCA clinical trials.Methods-We conducted a literature review between 1990 and 2006 in MEDLINE using the following MeSH headings: swine, dogs, resuscitation, heart arrest, EMS, EMT, ambulance, ventricular fibrillation, drug therapy, epinephrine, vasopressin, amiodarone, lidocaine, magnesium, and sodium bicarbonate. We reviewed the abstracts of 331 studies and 197 full manuscripts. Exclusion criteria included: non-peer reviewed, all without primary animal data, and traumatic models. From these, we identified 119 papers that contained unique information on time to medication administration. The data are reported as mean, ranges, and 95% confidence intervals. Mean time to first drug administration in animal laboratory studies and clinical trials was compared with a t-test. Regression analysis was performed to determine if time to drug predicted ROSC.Results-Mean time to first drug administration in 2378 animals was 9.5 minutes (range 3.0-28.0; 95% CI around mean 2. 78, 16.22). This is less than the time reported in clinical trials (19.4 min, p<0.001). Time to drug predicted ROSC (Odds Ratio 0.844; 95% CI 0.738, 0.966).Conclusion-Shorter drug delivery time in animal models of cardiac arrest may be one reason for the failure of animal studies to translate successfully into the clinical arena.

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“…19 Another study conducted, using a swine cardiac arrest model, concluded that vasopressin with or without epinephrine and norepinephrine resulted in higher myocardial and cerebral perfusion than with epinephrine alone. 20 In people, a recent meta-analysis showed that the combination use of both drugs led to significantly higher 24-hour survival rates. 21,22 The RE-COVER guidelines for ALS conclude that the use of vasopressin with or without epinephrine is a reasonable intervention during CPR.…”

Section: Discussionmentioning

confidence: 99%

Successful cardiopulmonary resuscitation following cardiopulmonary arrest in a geriatric chinchilla

Fernandez

Peyton

Miller

et al. 2013

J Vet Emergen Crit Care

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Published reports from clinical practice on the outcomes of CPR for exotic small mammals are limited. This report details the successful outcome of the use of combined basic and advanced life support measures for the provision of CPR in a chinchilla. This report also highlights the utility of an intraosseous catheter for administration of drugs and fluids novel to this species during resuscitation and recovery. To the authors' knowledge this is the first published report of successful CPR following CPA in a geriatric chinchilla.

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Effects of combined administration of vasopressin, epinephrine, and norepinephrine during cardiopulmonary resuscitation in pigs*

Cited by 25 publications

References 33 publications

Fresh frozen plasma: Friend or faux pas in critical illness?*

Fresh frozen plasma: Friend or faux pas in critical illness?*

Drug administration in animal studies of cardiac arrest does not reflect human clinical experience

Successful cardiopulmonary resuscitation following cardiopulmonary arrest in a geriatric chinchilla

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