Effects of combined endurance and resistance training in Amyotrophic Lateral Sclerosis: A pilot, randomized, controlled study

Merico, Antonio; Cavinato, Marianna; Gregorio, Caterina; Lacatena, Alessandra; Gioia, Elisabetta; Piccione, Francesco; Angelini, Corrado

doi:10.4081/ejtm.2018.7278

Cited by 52 publications

(51 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In another study, conducted in a few SLA patients with respiratory failure, exercise slowed the clinical deterioration of the disease [28]. Current studies support the effectiveness of exercise in patients with motoneuron disease: two recent clinical trials in ALS patients [9,29] demonstrated safety and tolerability of resistance and endurance training. Lunetta and collaborators [30] proved that monitored exercise programs reduce motor deterioration.…”

Section: Discussionmentioning

confidence: 90%

“…Recent studies suggest that skeletal muscle contributes to a retrograde signaling cascade that impairs motor neurons [6][7][8]. In a trial [9] we found that regular, rehabilitative exercise in ALS patients helps to reduce pain and fatigue of skeletal muscle origin. If a patient is inactive, the loss of training and disuse leads to muscular atrophy, which adds to the weakness and muscular atrophy caused by denervation and degeneration of motor neurons in ALS.…”

Section: Introductionmentioning

confidence: 86%

“…The rehabilitation programme consisted of an individualized progressive training of muscular strengthening and aerobic endurance exercises to avoid muscle damage, performed daily for 6 weeks during hospitalization. In relation to the disability the ALS patients performed a cycle ergometer, ergometry arm-leg and/ or treadmill or a standard rehabilitation consisting of a one-hour session of stretching, active mobilization, and general reinforcement as previously described [9]. In addition, all ALS patients underwent speech, occupational, and psychological therapy.…”

Section: Patient Rehabilitation Protocolmentioning

confidence: 99%

“…Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 30 October 2018 doi:10.20944/preprints201810.0709.v1Peer-reviewed version available at Brain Sci. 2019,9,8; doi:10.3390/brainsci9010008…”

mentioning

confidence: 99%

See 3 more Smart Citations

Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

Pegoraro¹,

Merico²,

Angelini³

2018

Preprint

Self Cite

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads from lower motor neuron involvement to progressive muscle atrophy, weakness, fasciculations for the upper motor neuron involvement to spasticity. Muscle atrophy in ALS is caused by a dysregulation in the molecular network controlling fast and slow muscle fibres. Denervation and reinnervation processes in skeletal muscle occur in the course of ALS and are modulated by rehabilitation. MicroRNAs (miRNAs) are small non-coding RNAs that modulate a wide range of biological functions under various pathophysiological conditions. MiRNAs can be secreted by various cell types and they are markedly stable in body fluids. MiR-1, miR-133 a, miR-133b, and miR-206 are called “myomiRs” and are considered markers of myogenesis during muscle regeneration and neuromuscular junction stabilization or sprouting. We observed a positive effect of a standard aerobic exercise rehabilitative protocol conducted for six weeks in 18 ALS patients during hospitalization in our center. We correlated clinical scales with molecular data on myomiRs. After six weeks of moderate aerobic exercise, myomiRNAs were down-regulated, suggesting an active proliferation of satellite cells in muscle and increased neuromuscular junctions. Our data suggest that circulating miRNAs modulate during skeletal muscle recovery in response to physical rehabilitation in ALS.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 86%

Section: Patient Rehabilitation Protocolmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

Pegoraro¹,

Merico²,

Angelini³

2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…A number of clinical trials showed the benefit of physical exercise in ALS patients. In a recent study, a significant increase of the score of the functional independence scale was observed in ALS patients after a specific program training in which improvement of oxygen consumption, muscle strength and fatigue was reported [125]. An ALS-like condition was observed in old people [126] where physical exercise determined re-innervation of muscle fibers at neuromuscular junctions normally reduced by aging [126].…”

Section: Sirtuins In Neurodegenerative Disorders Of Interest For Rehamentioning

confidence: 98%

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Mongelli¹,

Gaetano²

2018

Preprint

View full text Add to dashboard Cite

A large body of evidence report about the positive effects of physical activity in some pathophysiological conditions associated with age. Physical exercise alone or in combination with other medical therapies, unquestionably, causes reduction of symptoms in chronic non-transmissible diseases often leading to significant amelioration or complete healing. The molecular basis of this exciting therapeutic outcome, however, remain obscure. Epigenetics, exploring at the interface between the environment and the remodelling of chromatin structure, promises to shed light on this intriguing matter possibly contributing to the identification of novel therapeutic targets. In this review, we shall focalize on the role of class III histone deacetylases (HDACs), sirtuins (Sirts), which altered function has been frequently associated to the pathogenesis of aging-associated diseases including cancer, cardiovascular, muscular, neurodegenerative, bones and respiratory diseases, often with a controversial role. Numerous studies, in fact, demonstrate that Sirt-dependent pathways are activated upon physical and cognitive exercises linking the modulation of mitochondrial function, DNA structure and gene expression to designed medical therapies eventually leading to tangible beneficial outcomes. However, in similar conditions, other studies assign to sirtuins a negative pathophysiological role. Nevertheless, to study sirtuins in chronic diseases might lead to improve life quality in the elderly.

show abstract

High‐frequency motor rehabilitation in amyotrophic lateral sclerosis: a randomized clinical trial

Zucchi

Malagoli

Fini

et al. 2019

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Exercise may be physically and psychologically important for people with ALS , especially in the earlier stages of the disease, and, as a consequence, current ALS clinical management includes individualized rehabilitation as part of multidisciplinary care because. However, while recent studies focused on which type of exercise is more indicated to ALS patients, there is no evidence at which frequency training sessions should be performed. Methods We performed an assessor blinded randomized clinical trial to investigate the superiority of two different frequencies of exercise on rate of progression in ALS . We enrolled 65 patients in two groups: intensive exercise regimen ( IER , five sessions/week) versus usual exercise regimen ( UER , two sessions/week). The primary aim was to assess if IER decreased disease progression, measured through Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised, with respect to UER . Secondary aims included assessment of adverse events, tracheostomy‐free survival, motor and respiratory functions, fatigue, quality of life and caregiver burden. Treatment regimen consisted for both groups of the same kind of exercise including aerobic training, endurance training, stretching or assisted active mobilization, differing for frequency of intervention. Results No significant changes in disease progression were found in patients under IER versus UER . At the end of the study, there were no significant differences between the two groups in survival, respiratory function, time to supporting procedures, and quality of life. Adverse events, fatigue, and caregiver burden were not different between the two treatment regimens. Conclusions Despite some limitations, our trial demonstrated that high‐frequency physical exercise was not superior to UER on ALSFRS ‐R scores, motor and respiratory functions, survival, fatigue, and quality of life of ALS patients.

show abstract

Effects of combined endurance and resistance training in Amyotrophic Lateral Sclerosis: A pilot, randomized, controlled study

Cited by 52 publications

References 35 publications

Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

High‐frequency motor rehabilitation in amyotrophic lateral sclerosis: a randomized clinical trial

Contact Info

Product

Resources

About