Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic changes in peripheral blood lymphocytes

Belyaeva, A. G.; Кудрин, В. С.; Koshlan, I. V.; Koshlan, N. A.; Isakova, Mariya D.; Bogdanova, Y. V.; Тимошенко, Г. Н.; Krasavin, E. A.; Blokhina, Taisia; Yashkina, E I; Осипов, А. Н.; Nosovsky, Andrey N.; Perevezentsev, A. A.; Штемберг, А. С.

doi:10.1016/j.lssr.2021.05.004

Cited by 4 publications

(1 citation statement)

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“…After 40 days, the same monkeys were re-irradiated by 12 C (1 Gy, 10 keV/µm, head only), which caused learning disabilities in monkeys with the strong and unbalanced (excitable) but not with the strong and balanced type of higher nervous activity [ 11 ]. Recently, these data have been confirmed using lower doses of IR (combined 1 Gy γ-rays, 0.23 Gy/h and 12 C, 1 Gy, 10 keV/µm), but it should be kept in mind that in this study the combined effects of IR and antiorthostatic hypokinesia were used [ 100 ]. Taken together, this data confirms the paramount role of the animals’ emotional state in the manifestation of HZE effects on CNS functions, which was hypothesized previously [ 54 ].…”

Section: Cognition and Ionizing Radiationmentioning

confidence: 69%

The Effects of Galactic Cosmic Rays on the Central Nervous System: From Negative to Unexpectedly Positive Effects That Astronauts May Encounter

Kokhan

Dobynde

2023

Biology

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Galactic cosmic rays (GCR) pose a serious threat to astronauts’ health during deep space missions. The possible functional alterations of the central nervous system (CNS) under GCR exposure can be critical for mission success. Despite the obvious negative effects of ionizing radiation, a number of neutral or even positive effects of GCR irradiation on CNS functions were revealed in ground-based experiments with rodents and primates. This review is focused on the GCR exposure effects on emotional state and cognition, emphasizing positive effects and their potential mechanisms. We integrate these data with GCR effects on adult neurogenesis and pathological protein aggregation, forming a complete picture. We conclude that GCR exposure causes multidirectional effects on cognition, which may be associated with emotional state alterations. However, the irradiation in space-related doses either has no effect or has performance enhancing effects in solving high-level cognition tasks and tasks with a high level of motivation. We suppose the model of neurotransmission changes after irradiation, although the molecular mechanisms of this phenomenon are not fully understood.

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Section: Cognition and Ionizing Radiationmentioning

confidence: 69%