Effects of Combined Interventions of Exercise and Diet or Exercise and Supplementation on Breast Cancer Patients: A Systematic Review

Abstract

This systematic review investigated the effects of exercise interventions combined with diet and/or dietary supplement interventions on anthropometry, body composition, metabolic biomarkers, physical function, healthy lifestyles, quality of life, psychosocial variables and fatigue for women with breast cancer. A systematic search was performed in the PubMed and Web of Science databases (from inception to 1 March 2022). A review was carried out following the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) guidelines. The methodological quality and the risk of bias of the included studies was assessed with the Physiotherapy Evidence Database (PEDro) scale. A total of 13 randomised controlled trial studies were included, comprising 1569 breast cancer patients. The main finding of this systematic review is that groups performing interventions combining exercise plus diet show significant improvements in cardiorespiratory fitness, muscular strength, body composition, quality of life, fatigue, anxiety, depression and sleep compared to control groups. On the other hand, the use of interventions combining exercise plus supplementation does not result in an improvement compared to groups using exercise alone or supplementation alone.

Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

“…Nevertheless, lifestyle and nutrition has changed within the last 30 years, which could also be a possible explanation for this difference. A recent systematic review indicated the importance of exercise interventions as well as supplement interventions (e.g., vitamin D) in breast cancer patients, and their positive effects on cardiorespiratory fitness, body composition, and quality of life [ 37 ].…”

Differential Impact of Exercises on Quality-of-Life Improvement in Breast Cancer Survivors: A Network Meta-Analysis of Randomized Controlled Trials

“…The search was conducted in the aforementioned databases to scrutinize eligible trials. Additionally, the reference lists of various review articles [ 5 , 7 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] were examined and manual searches were performed. In situations where the two initial reviewers were unable to reach a consensus, a third reviewer and study author (PLC) was consulted.…”

The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

“…Compared with control groups, groups who performed interventions that combine exercise and diet demonstrate significant improvements in cardiorespiratory fitness, muscle strength, body composition, quality of life, fatigue, anxiety, depression, and sleep. Conversely, exercise combined with supplementation does not result in an improvement over exercise alone or supplementation alone [ 171 ].…”