Effects of combined treatment with blood flow restriction and low‐intensity electrical stimulation on diabetes mellitus‐associated muscle atrophy in rats

Tanaka, Minoru; Morifuji, Takeshi; Yoshikawa, Makoto; Nakanishi, Ryosuke; Fujino, Hidemi

doi:10.1111/1753-0407.12857

Cited by 11 publications

(12 citation statements)

References 48 publications

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“…Receptor for advanced glycation end products (RAGE) is a transmembrane signaling receptor that is associated with diabetic renal and vascular complications. AGEs can induce muscle atrophy or myogenesis impairment through the RAGE-mediated, AMPK-induced downregulation of AKT signaling ( 51 ). Furthermore, AGEs have been shown to modulate muscle anabolic signaling by inhibiting the mTORC1 signaling pathway ( 50 ).…”

Section: Molecular Mechanism Of Diabetic Muscular Atrophymentioning

confidence: 99%

Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies

Shen

Wang

et al. 2022

Front. Endocrinol.

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Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types, dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications gradually increase as the disease progresses. Studies in diabetes complications have mostly focused on kidney and cardiovascular diseases, as well as neuropathy. However, DM can also cause skeletal muscle atrophy. Diabetic muscular atrophy is an unrecognized diabetic complication that can lead to quadriplegia in severe cases, seriously impacting patients’ quality of life. In this review, we first identify the main molecular mechanisms of muscle atrophy from the aspects of protein degradation and synthesis signaling pathways. Then, we discuss the molecular regulatory mechanisms of diabetic muscular atrophy, and outline potential drugs and treatments in terms of insulin resistance, insulin deficiency, inflammation, oxidative stress, glucocorticoids, and other factors. It is worth noting that inflammation and oxidative stress are closely related to insulin resistance and insulin deficiency in diabetic muscular atrophy. Regulating inflammation and oxidative stress may represent another very important way to treat diabetic muscular atrophy, in addition to controlling insulin signaling. Understanding the molecular regulatory mechanism of diabetic muscular atrophy could help to reveal new treatment strategies.

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Section: Molecular Mechanism Of Diabetic Muscular Atrophymentioning

confidence: 99%

Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies

Shen

Wang

et al. 2022

Front. Endocrinol.

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“…Therefore, the fast‐twitch muscle causes capillary regression to a greater extent compared with the slow‐twitch muscle. In addition, the fast‐twitch muscle results from harmful effects such as muscle atrophy and dysfunction of mitochondrial metabolism due to a low tolerance to hyperglycemia induced‐oxidative stress compared with slow‐twitch muscle in diabetic conditions (Ciciliot et al, 2013; Nakamoto & Ishihara, 2020; Tanaka et al, 2019). Furthermore, fast‐twitch muscle in the hindlimb plays an important role as locomotor and for physical activity (Ikezoe et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus (DM) is a widely prevalent metabolic disorder that is associated with a marked increase in hyperglycemia‐induced diabetic complications (Tanaka et al, 2019; Zhao et al, 2014). Hyperglycemia leads to diverse complications such as muscle atrophy (Tanaka et al, 2019), insulin resistance, and a decline in the number of capillaries in skeletal muscle (Lillioja et al, 1987). In particular, type 2 diabetes is, in essence, a vascular disease that is frequently associated with capillary regression, which is a diabetic complication (Ko et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of low‐intensity endurance exercise for severe hyperglycemia‐induced capillary regression in non‐obese type 2 diabetes rat skeletal muscle

et al. 2021

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“…Nonetheless, the results support the use of BFRT in this population with clinically relevant improvements in hemodynamics and relevant metabolic syndrome markers. In addition, a recent study on rats with DM displayed that BFRT plus electrical stimulation prevented diabetes-associated muscle atrophy, highlighting that muscular responses to BFR exercise can be elicited despite the impaired systemic changes (albeit with evoked electrical stimulation) ( Tanaka et al, 2019 ).…”

Section: Diabetes Mellitus and Blood Flow Restriction Trainingmentioning

confidence: 99%

A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation

et al. 2022

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Blood flow restriction training (BFRT) is a modality with growing interest in the last decade and has been recognized as a critical tool in rehabilitation medicine, athletic and clinical populations. Besides its potential for positive benefits, BFRT has the capability to induce adverse responses. BFRT may evoke increased blood pressure, abnormal cardiovascular responses and impact vascular health. Furthermore, some important concerns with the use of BFRT exists for individuals with established cardiovascular disease (e.g., hypertension, diabetes mellitus, and chronic kidney disease patients). In addition, considering the potential risks of thrombosis promoted by BFRT in medically compromised populations, BFRT use warrants caution for patients that already display impaired blood coagulability, loss of antithrombotic mechanisms in the vessel wall, and stasis caused by immobility (e.g., COVID-19 patients, diabetes mellitus, hypertension, chronic kidney disease, cardiovascular disease, orthopedic post-surgery, anabolic steroid and ergogenic substance users, rheumatoid arthritis, and pregnant/postpartum women). To avoid untoward outcomes and ensure that BFRT is properly used, efficacy endpoints such as a questionnaire for risk stratification involving a review of the patient’s medical history, signs, and symptoms indicative of underlying pathology is strongly advised. Here we present a model for BFRT pre-participation screening to theoretically reduce risk by excluding people with comorbidities or medically complex histories that could unnecessarily heighten intra- and/or post-exercise occurrence of adverse events. We propose this risk stratification tool as a framework to allow clinicians to use their knowledge, skills and expertise to assess and manage any risks related to the delivery of an appropriate BFRT exercise program. The questionnaires for risk stratification are adapted to guide clinicians for the referral, assessment, and suggestion of other modalities/approaches if/when necessary. Finally, the risk stratification might serve as a guideline for clinical protocols and future randomized controlled trial studies.

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Effects of combined treatment with blood flow restriction and low‐intensity electrical stimulation on diabetes mellitus‐associated muscle atrophy in rats

Abstract: Combination treatment with Bfr and ES may prevent diabetes-associated muscle atrophy by upregulating inhibition of AGEs, which leads to the activation of protein synthesis.

Cited by 11 publications

References 48 publications

Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies

Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies

Preventive effects of low‐intensity endurance exercise for severe hyperglycemia‐induced capillary regression in non‐obese type 2 diabetes rat skeletal muscle

A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation

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