Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

Hwang, Tae‐Kon; Song, Min-Young; Ahn, Sora; Oh, Ju-Young; Kim, Dong‐Hee; Liu, Quan Feng; Lee, Wonwoong; Ji, Hong; Jeon, Songhee; Park, Hi-Joon

doi:10.1155/2019/3612587

Cited by 10 publications

(10 citation statements)

References 52 publications

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Section: Discussionsupporting

confidence: 88%

“…The combination of acupuncture and medication promotes the relieving effects of symptoms than mere acupuncture or drug administration, indicating a synergistic effect between acupuncture and medicine in the therapy of OIC. This phenomenon agrees with the enhancer role of acupuncture for drugs observed in treating other diseases, like Parkinson's disease 38 and methamphetamine addiction. 39 In addition to the moderate improvement of therapeutic effects of acupuncture versus drug applications, the quality of life of OIC patients has significantly improved regardless of the mere usage of acupuncture or with co-interventional prescriptions.…”

Section: Total (95% Ci) Prediction Intervalsupporting

confidence: 88%

See 1 more Smart Citation

Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy – A Meta-Analysis and Systematic Review

Han¹,

Liu²,

Fan³

et al. 2021

CLEP

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Cancer pain is a common problem in clinical cancer therapy. Opioid analgesia is one of the most effective drugs for pain relief with satisfying performance besides the side effect of opioid-induced constipation (OIC). Acupuncture, as a Chinese traditional non-invasive intervention, has been applied to clinical cancer pain management and functional constipation therapy. However, only a few studies have adopted this treatment for OIC patients. Due to limited numbers of investigated subjects and variability of application methods, including treatment apparatus, acupoints, durations, and sessions, the interpretation of acupuncture’s therapy effects from single-site randomized clinical trials (RCT) is limited. Therefore, we conducted a meta-analysis by collecting published data from Pubmed, Embase, Cochrane library, and Web of Science. Five RCTs focusing on the application of acupuncture with or without medication in OIC patients were included. An overall remission rate of 86.8% in the acupuncture-treated group was achieved, higher than the control group (78.9%; RR, 1.10, 95% CI [1.03, 1.18]). The symptom scores, reporting on defecation frequency, defecation straining, abdominal pain, defection time, and stool property, in acupuncture groups were lower than control groups with a standardized mean difference (SMD) of −2.21 [−4.15, −0.27]. The quality of life (QOL) for patients in the acupuncture treated group increased compared to the control group with reduced PAC-QOL scores (SMD, −1.02 [−1.78, −0.26]). Referring to the effects from pure acupuncture treatment (SMD, −0.43 [−0.83, −0.03]), the co-intervention of acupuncture and drugs (SMD, −1.77 [−2.51, −1.02]) improved the life quality of patients more remarkably (P < 0.05). Overall, our data confirmed the therapeutic effects of acupuncture in the treatment of OIC. The co-intervention of acupuncture with drugs improves the outcomes of OIC patients better than a single strategy. Combined therapy with both medicine and acupuncture has insightful potential for future clinical cancer patient management on constipation problems.

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Section: Discussionsupporting

confidence: 88%

Section: Total (95% Ci) Prediction Intervalsupporting

confidence: 88%

Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy – A Meta-Analysis and Systematic Review

Han¹,

Liu²,

Fan³

et al. 2021

CLEP

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“…MA at GB34 can activate the ERK signaling pathway in the skin of a mouse pain model and the SN of an MPTP-induced PD mouse model, and EA at GB34 can activate ERK signaling in the hippocampus of neuropathic pain rats, as well as stressed rats. 19 , 20 , 21 , 22 These results suggest that EA at GB34 can activate the BDNF/ERK signaling pathway.…”

Section: Discussionmentioning

confidence: 76%

Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson's disease

Lee

Bae

et al. 2023

Journal of Traditional and Complementary Medicine

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“…50 Hz EA at GB34 and LR3 has been shown to increase BDNF and downstream p-Akt levels [67], improving rotational behavior in a rat model of unilateral MPP injury, and another study revealed that inhibition of the PI3K/Akt signaling pathway blocked the protective effect of acupuncture on DA neurons [69]. Acupuncture at GB34 combined with KD5040 downregulated pIκBα and upregulated pAkt, pGSK3β, pERK, pCREB, and BDNF, which significantly improve motor function [70]. Therefore, the results presented above suggest that BDNF/TrkB and their downstream signaling pathways may mediate the neuroprotective effects of acupuncture in PD treatment.…”

Section: Apoptosismentioning

confidence: 97%

Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit

et al. 2021

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Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra. Existing pharmaceutical treatments offer alleviation of symptoms but cannot delay disease progression and are often associated with significant side effects. Clinical studies have demonstrated that acupuncture may be beneficial for PD treatment, particularly in terms of ameliorating PD symptoms when combined with anti-PD medication, reducing the required dose of medication and associated side effects. During early stages of PD, acupuncture may even be used to replace medication. It has also been found that acupuncture can protect dopaminergic neurons from degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic pathways as well as modulating the neurotransmitter balance in the basal ganglia circuit. Here, we review current studies and reflect on the potential of acupuncture as a novel and effective treatment strategy for PD. We found that particularly during the early stages, acupuncture may reduce neurodegeneration of dopaminergic neurons and regulate the balance of the dopaminergic circuit, thus delaying the progression of the disease. The benefits of acupuncture will need to be further verified through basic and clinical studies.

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Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

Cited by 10 publications

References 52 publications

Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy – A Meta-Analysis and Systematic Review

Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy – A Meta-Analysis and Systematic Review

Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson's disease

Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit

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