It is well recognized that the outcomes of investigations conducted in the field of basic sciences, as well as the achievements gained over the period of these studies, mediate effective and useful outcomes not only for basic sciences, but also for many other fields as diverse from engineering to medicine. In this regard, theoretical researches on the production routes of various radioisotopes that could be implemented in a numerous of fields ensure that physics and other associated areas interact on a common ground. Taking this fact into account as the motivation, the goal of this study is set to investigate how various deuteron and alpha optical models impact the cross–section calculations of 22,24Na radioisotopes, which are known to be utilized in medical applications. The TALYS (v1.95) code was utilized in the calculations, which allows for the use of five different deuteron and eight different alpha optical model alternatives. The obtained results were not only visually compared to the existing experimental data in the literature, but also quantitatively by performing mean weighted deviation and relative variance analyses.