Effects of combining tactile with visual and spatial cues in conditioned place preference

Cunningham, Christopher L.; Zerizef, Courtney L.

doi:10.1016/j.pbb.2014.07.012

Cited by 8 publications

(23 citation statements)

References 25 publications

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“…3, 4, and 5), grid and hole floors were separated during conditioning by a clear acrylic divider placed in the center of the apparatus. Previous research in our lab shows no difference in the magnitude of ethanol-induced CPP produced by these configurations in DBA/2J mice trained in the dark (Cunningham and Zerizef, 2014). Moreover, given the variation in CPP procedures across laboratories, our inclusion of two common configurations allows for greater generality of our conclusions.…”

Section: Methodsmentioning

confidence: 59%

The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice

et al. 2015

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Drug-associated stimuli are considered important factors in relapse to drug use. In the absence of drug, these cues can trigger drug craving and drive subsequent drug seeking. One structure that has been implicated in this process is the bed nucleus of the stria terminalis (BNST), a chief component of the extended amygdala. Previous studies have established a role for the BNST in cue-induced cocaine seeking. However, it is unclear if the BNST underlies cue-induced seeking of other abused drugs such as ethanol. In the present set of experiments, BNST involvement in ethanol-seeking behavior was assessed in male DBA/2J mice using the conditioned place preference procedure (CPP). The BNST was inhibited during CPP expression using electrolytic lesions (Experiment 1), co-infusion of GABAA and GABAB receptor agonists muscimol and baclofen (M+B; Experiment 2), and activation of inhibitory designer receptors exclusively activated by designer drugs (hM4Di-DREADD) with clozapine-N-oxide (CNO; Experiment 3). The magnitude of ethanol CPP was reduced significantly by each of these techniques. Notably, infusion of M+B (Exp. 2) abolished CPP altogether. Follow-up studies to Exp. 3 showed that ethanol cue-induced c-Fos immunoreactivity in the BNST was reduced by hM4Di activation (Experiment 4) and in the absence of hM4Di, CNO did not affect ethanol CPP (Experiment 5). Combined, these findings demonstrate that the BNST is involved in the modulation of cue-induced ethanol-seeking behavior.

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Section: Methodsmentioning

confidence: 59%

The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice

et al. 2015

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“…Cunningham and Zerizef reported CPP from visual and spatial cues in the light or in the dark. 31) Further, Varela et al 32) reported that chronic complete light deprivation for 4 weeks inhibited appetitive associative learning induced by EtOH. Although methamphetamine and EtOH have very different mechanisms and subjective effects, a larger cage in which mice can move freely has been linked to greater methamphetamine-induced sensitization.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Shimizu

Oki

Mitani

et al. 2015

Biological & Pharmaceutical Bulletin

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The rewarding effects of alcohol can lead to progressively heavier and more frequent drinking. Since studies of reward have mainly focused on responses to higher alcohol doses, the relations between reward and moderate/sustained alcohol exposure remain unknown. Our objective was to evaluate factors affecting the reward value of low alcohol doses and risk factors for increasing alcohol doses due to reward progression caused by alcohol exposure patterns. We thus performed conditioned place preference (CPP) and ethanol (EtOH)-induced locomotor sensitization tests in mice. Low-dose EtOH (0.5 or 1 g/kg twice/week)-induced CPP was stronger than that produced by saline control treatment, but the effect decreased with increasing numbers of conditioning trials. Moderate-dose/long-term EtOH exposure induced a weaker CPP than high-dose/short-term EtOH (2 g/kg twice/week) exposure with the same total EtOH dose (8 g/kg/experiment). Acamprosate calcium, an anti-relapse drug, preclusively reduced EtOH-induced CPP. EtOH induced CPP and locomotor sensitization in black but not white chamber, although the initial preference and the basal locomotion in each chamber were equal. Therefore the brightness of the chamber had an effect on EtOHinduced sensitization. Moreover, additional studies indicated that EtOH-induced locomotor sensitization also depends on the dose but not the administration interval. Paired associative learning with EtOH exposure is a potent factor influencing the level of reward produced by EtOH. Moreover, exposure to high doses of alcohol, even on an intermittent schedule, carries a higher risk of addiction than exposure to moderate doses over longer periods.Key words moderate alcohol (ethanol: EtOH); conditioned place preference (CPP); reward; sensitization; paired associative learning Alcohol abuse is associated with serious physical and psychiatric illnesses, financial hardships, familial dysfunction, and violence, all of which place a substantial burden on society. Heavy alcohol consumption and long-term drinking increase the risk of alcohol-related diseases such as liver cirrhosis, cancer, pancreatitis, and depression. 1,2) In response, the World Health Organization (WHO) recently approved a Global Strategy to Reduce Harmful Use of Alcohol urging all countries to strengthen national responses to public health problems caused by alcohol use.3) In Japan, 6.45 million people suffer from alcohol-related problems, with an estimated annual economic loss of 4.15 trillion yen associated with alcohol. 4) In December 2013, the Basic Act on Measures against Alcohol-related Health Harm was enacted in Japan, promoting education about drinking in moderation to prevent alcoholrelated problems.Regular consumption of alcohol increases the propensity for addiction because of the rewarding effects of alcohol. Thus, many casual drinkers gradually increase total alcohol consumption, which becomes habitual over time. Although many studies in rodents have been conducted on chronic drinking and reward, 5-7) previous studies have ma...

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“…Neither of those studies directly compared the specific cue configurations used here with ethanol, but a cross-experiment visual comparison of data reported by Cunningham and Zerizef (2014: Exps. 1 vs. 2) suggested no cue-configuration effect in D2 mice after four conditioning trials, an observation consistent with the results of Exp.…”

Section: Discussionmentioning

confidence: 99%

“…The alternative tactile cues are isolated to different spatial locations only at the time of preference testing.This procedure contrasts with the more commonly used two-compartment (2C) procedure that exposes animals to spatially distinct portions of the apparatus that typically differ in their cue properties during conditioning trials. More thorough theoretical descriptions of differences between the 1C and 2C procedures can be found elsewhere (Cunningham et al 2006b; Cunningham and Zerizef 2014; Hitchcock et al 2014). …”

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confidence: 99%

“…The cue configurations used here were adapted from previous studies in D2 mice that examined effects of apparatus illumination on ethanol-induced conditioning to tactile cues in the 1C and 2C procedures (Cunningham and Zerizef 2014). Those studies showed no difference between procedures when training occurred in the dark, indicating no effect of adding spatial cues in the absence of visual cues.…”

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confidence: 99%

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Effects of multi-modal cues on conditioned place preference in C57BL/6J and DBA/2J mice

Cunningham

Shields

2018

Psychopharmacology

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Rationale Previous work has shown that some mouse strains (e.g., DBA/2J [D2]) readily develop robust ethanol-induced conditioned place preference (CPP) while others (e.g., C57BL/6J [B6]) do not. Though commonly interpreted as a difference between strains in sensitivity to ethanol reward, other explanations for this finding are possible. Objectives To explore the hypothesis that variation in sensitivity to contextual cues underlies CPP differences, the present work investigated ethanol-induced CPP in D2 and B6 mice trained with a standard tactile (floor) cue procedure compared to mice trained with tactile plus visual-spatial cues. Methods In an unbiased CPP procedure, mice were assigned to either a single element cue (one-compartment apparatus with tactile cue presented in the dark) or multimodal cues (two-compartment apparatus with distinct tactile floors and lights on). To track CPP development, mice received preference tests during training in addition to a final test. Results Adding visual-spatial cues accelerated CPP acquisition in both D2 and B6 mice. However, this enhancement was observed after just one ethanol-conditioning trial in D2 mice, but was observed only after four ethanol-conditioning trials in B6 mice. Differences between groups trained with single or multimodal cues disappeared as conditioning reached asymptote, with D2 mice showing a more rapid loss of the effect and a higher maximum CPP. Conclusions Although multimodal cues produce more rapid conditioning, their inability to reduce or eliminate strain differences in CPP supports the interpretation that these strains differ in their sensitivity to ethanol reward.

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Effects of combining tactile with visual and spatial cues in conditioned place preference

Cited by 8 publications

References 25 publications

The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice

The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice

Factors Affecting Ethanol-Induced Conditioned Place Preference and Locomotor Sensitization in Mice

Effects of multi-modal cues on conditioned place preference in C57BL/6J and DBA/2J mice

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