Maneuver load alleviation, gust load alleviation, and natural laminar flow are integrated into aircraft conceptual design. The concurrent design of the aircraft and its active load alleviation systems can yield significant gains. The simultaneous application of maneuver load alleviation and gust load alleviation to a short-haul aircraft leads to an 11% reduction in fuel burn and 7% reduction in direct operating cost. These savings are diminished if maneuver load alleviation and gust load alleviation are applied independently. The synergy between active load control and natural laminar flow is also explored. It is possible to invest some of the weight savings from load alleviation to achieve extensive laminar flow. The combination of load alleviation and natural laminar flow increases the fuel and cost savings to upwards of 18 and 11%, respectively. It is concluded that load alleviation can shift the transonic transport optimum toward low-sweep, natural laminar flow wings. Sensitivity studies finally demonstrate that contemporary commercial aircraft should be able to meet the control requirements for effective gust load alleviation.