Effects of concomitant exposure to styrene and intense noise on rats’ whole lung tissues. Biochemical and histopathological studies

Haghighat, Mojtaba; Allameh, Abdolamir; Fereidan, Mohammad; Khavanin, Ali; Ghasemi, Zahrasadat

doi:10.1080/01480545.2019.1662033

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…Also, there was a meaningful relationship between the group exposed to noise + toluene and the group exposed to noise, which demonstrates that noise can have a synergic effect on toluene's capability to produce MDA. These results correspond with the results of several other studies in which exposure to organic solvents and noise leads to higher levels of induction of oxidative stress rather than either factor alone [21,22,27,28].…”

Section: Discussionsupporting

confidence: 91%

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Beyrami

niri

Panahi

et al. 2023

Preprint

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Background: Occupational and environmental exposures to organic solvents and noises in the workplace are major health issues. One of these solvents is toluene, and on top of that noise is an impartible part of any industry. the present study aims to determine the alteration of oxidative stress parameters and the histopathological changes caused by simultaneous exposure to toluene and noise in the brain tissue. Methods: For this purpose, 32 male Wistar rats were divided into four experimental groups and then were exposed to varying factors for 8 hours a day (8 h/day) for 28 days. These four groups were: 1) The control group, 2) The group exposed to noise (100dB), 3) The group exposed to toluene by inhalation (500 ppm), and 4) The group simultaneously exposed to both of them. In this study, the levels of lipid peroxidation (MDA) and glutathione (GSH) and the histopathological changes of the brain tissue were determined. Results:The findings suggest that, in the various parts of the temporal brain tissue simultaneously exposed to toluene and noise, the cohesion was more decreased compared to the tissues in other groups. Furthermore, in the group simultaneously exposed to both factors the MDA level increased and the GSH level decreased significantly. Conclusions: The results indicated the impact of synergistic interaction between noise and toluene on the accumulation of oxidation products, the progressive morphological damages as well as the weakening of the antioxidant defense system in brain tissues of rats and being simultaneously exposed to both factors has a cumulative effect

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Section: Discussionsupporting

confidence: 91%

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Beyrami

niri

Panahi

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…The thicknesses of the interalveolar septa showed significant increase in SO group in comparison with control groups, this was supported by the results of Coccini et al [3], Arab et al [7] and Haghighat et al [57]. The increased thickness of the interalveolar septa may be explained by the histological findings of increased cellular proliferation in lung alveoli, in agreement with Kaufman et al [58], capillary dilation, and interalveolar infiltration, in concordance with Yaman et al [59].…”

Section: Discussionsupporting

confidence: 82%

Pneumotoxicity of Styrene Oxide and the Possible Protective Role of Thymosin β4 in Albino Rat: Biochemical and Immunohistochemical Study

Abdelwahab

Abozaid²,

Abdel-Kareem³

2023

Zagazig University Medical Journal

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Background: Styrene (ST) has been used for plastic and resin production. It was reported to induce injury of pulmonary tissues. Thymosin β4 (Tβ4), a naturally expressed protein, was reported to have antioxidant, anti-inflammatory, antiapoptotic, and regenerative properties. Aim of study: This study was designed to examine the role of Tβ4 in ameliorating Styrene Oxide (SO)-induced complication on the lung tissues and its potential mechanisms. Material and methods: Forty adult male Wistar albino rats were allocated randomly into 4 groups, 10 rats each. Control group: rats were injected intraperitoneally (i.p.) with 0.5cm physiological saline. Tβ4 group: rats were injected i.p. with 1mg/kg of Tβ4. SO group: rats were injected i.p. with 300 mg/kg of SO. SO+ Tβ4 group: rats were concomitantly injected i.p. with 300 mg/kg of SO and 1mg/kg of Tβ4. All chemicals were given once daily for 28 days. Results: There was a high significant decrease in the body weight, TAO and GSH levels and a significant increase in lung indices, inflammatory markers (TNF-α, IL-1β, and IL-13) and lipid peroxidation marker (MDA) levels in SO group. Also, there was a high significant increase in TGF-β1 and decrease in PGE2 in the SO group. SO also induced marked histopathological changes in lung tissues involving thickened interalveolar septa, collapsed alveoli, and infiltration by inflammatory cells. Also, there were excess collagen fiber depositi ons, increased number of macrophage cells, and positive α-SMA, CD68 and VEGF immunoreactivity. These results were significantly ameliorated via Tβ4 administration. Conclusion: Tβ4 was effective in preserving the structure and function of the lung after the injury induced by SO.

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“…However, our results consider the potential synergistic and antagonistic effects between VOCs, which were not considered in previous studies. Acrylonitrile and styrene are widely used industrial organic substances, and they are similar to the other VOCs in that they produce oxidative stress and are harmful to human health [ 46 , 47 ]. However, no study on the two VOCs and lipid profiles was found, and we need to conduct more research to explore these associations in the future.…”

Section: Discussionmentioning

confidence: 99%

The association between exposure to volatile organic compounds and serum lipids in the US adult population

Chen,

Fu,

et al. 2023

Lipids Health Dis

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Background and Aim Epidemiological evidence on the relationship between exposure to volatile organic compounds (VOCs), both single and mixed, and serum lipid levels is limited, and their relationship remains unclear. Our study aimed to investigate the associations of exposure to VOCs with serum lipid levels in the US adult population. Methods and results The study examined the association of 16 VOC levels (2-methylhippuric acid, 3- and 4-methylhippuric acid, N-acetyl-S-(2-carbamoylethyl)-L-cysteine, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine, 2-aminothiazoline-4-carboxylic acid, N-acetyl-S-(benzyl)-L-cysteine, N-acetyl-S-(n-propyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine, N-acetyl-S-(2-cyanoethyl)-L-cysteine, N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine, N-acetyl-S-(2-hydroxypropyl)-L-cysteine. N-Acetyl-S-(3-hydroxypropyl)-L-cysteine, mandelic acid, N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine, phenylglyoxylic acid and N-acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine) with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) using data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2015, and a total of 1410 adults were enrolled. The association was evaluated by Bayesian kernel machine regression (BKMR), multiple linear regression and weighted quantile sum (WQS) regression. In BKMR analysis, exposure to VOCs is positively correlated with levels of TC, TG, and LDL-C. However, statistical significance was observed only for the impact on TG. Our linear regression analysis and WQS regression generally support the BKMR results. Several VOCs were positively associated with serum lipid profiles (e.g., the ln-transformed level of mandelic acid (MA) displayed an increase in estimated changes of 7.01 (95% CIs: 2.78, 11.24) mg/dL for TC level), even after the effective number of tests for multiple testing (P < 0.05). Conclusions Exposure to VOCs was associated with serum lipids, and more studies are needed to confirm these findings.

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Effects of concomitant exposure to styrene and intense noise on rats’ whole lung tissues. Biochemical and histopathological studies

Cited by 7 publications

References 37 publications

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Pneumotoxicity of Styrene Oxide and the Possible Protective Role of Thymosin β4 in Albino Rat: Biochemical and Immunohistochemical Study

The association between exposure to volatile organic compounds and serum lipids in the US adult population

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