Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats

Rahman, Shaikh Mizanoor; Wang, Yuming; Yotsumoto, Hiroaki; Cha, Jae-Young; Han, Sang Hoon; Inoue, Shuji; Yanagita, Teruyoshi

doi:10.1016/s0899-9007(00)00584-0

Cited by 163 publications

(109 citation statements)

References 44 publications

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“…Studies have suggested that CLA increased fatty acid oxidation in mouse liver (Degrace et al, 2004) and a variety of tissues in rats (Rahman et al, 2001) via an increase in CPT-I activity. The present study showed that CPT-I activity in cod liver was not increased by dietary CLA, suggesting that mitochondrial β-oxidation would not be increased.…”

Section: Discussionmentioning

confidence: 99%

Influence of dietary conjugated linoleic acid (CLA) and tetradecylthioacetic acid (TTA) on growth, lipid composition and key enzymes of fatty acid oxidation in liver and muscle of Atlantic cod (Gadus morhua L.)

et al. 2007

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The aim of the present study was to determine the effects of conjugated linoleic acid (CLA) and tetradecylthioacetic acid (TTA) on growth performance, and lipid and fatty acid metabolism in Atlantic cod. The overall objective being to test the hypotheses that CLA and TTA have beneficial effects in cod culture including decreased liver size and proportion through decreased lipid content, and increased nutritional quality through effects on fatty acid compositions including accumulation of bioactive fatty acids, CLA and TTA, in flesh. Juvenile cod were fed for three months on fish meal and fish oil diets of basically commercial formulation, but containing either 0.5% or 1% CLA, or 0.5% TTA. The effects of the functional fatty acids on growth, feed efficiency, body proximate composition, liver weight and lipid composition, fatty acid compositions of flesh and liver, and key enzymes of fatty acid oxidation were determined. Dietary CLA and TTA had no effect on growth parameters in cod juveniles, but viscero-and hepato-somatic indices were increased in fish fed 0.5% CLA and TTA, respectively.Proximate composition of whole fish was not affected by CLA or TTA, and there were no major effects of either functional fatty acid on lipid contents and compositions of liver and flesh. Dietary CLA and TTA were both incorporated into tissue lipids, with CLA deposited to a greater extent in liver, whereas TTA was deposited to a greater extent in flesh. In liver, acyl CoA oxidase (ACO) activity, but not carnitine palmitoyltransferase-I (CPT-I), was increased by CLA, whereas dietary TTA increased both ACO and CPT-I activities. In contrast, ACO activity was reduced by both CLA and TTA in red and white muscle, whereas CPT-I activity was generally not affected by CLA and TTA in either muscle tissue. Therefore, the results only partially supported the hypotheses tested, as CLA and TTA had few beneficial effects in Atlantic cod and did not enhance growth parameters, or improve feed conversion or potential yield through decreased adiposity or liver lipid deposition. However, nutritional quality could be enhanced, and cod fed CLA and/or TTA could be beneficial in the human diet, through provision of bioactive fatty acids with no detrimental effects on n-3 PUFA levels.3

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Section: Discussionmentioning

confidence: 99%

Influence of dietary conjugated linoleic acid (CLA) and tetradecylthioacetic acid (TTA) on growth, lipid composition and key enzymes of fatty acid oxidation in liver and muscle of Atlantic cod (Gadus morhua L.)

et al. 2007

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“…48) Rat experiments have shown that dietary CLA decreased the level of TG in the plasma and the NEFA concentration. 11) In addition, Lin et al 49) have reported that a trans-10, cis-12 CLA treatment decreased the synthesis of TG and the secretion of Hep G2 cells. Corino et al 35) have reported that dietary CLA increased the plasma concentration of HDL cholesterol and decreased that of LDL cholesterol in rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…CLA has numerous beneficial physiological effects, including anti-cancer, [1][2][3] anti-diabetes, 4) enhancing the immune response, 5) reducing atherosclerasis, [6][7][8] and reducing fat mass. [9][10][11][12][13] Recent studies have shown cis-9, trans-11 CLA and trans-10, cis-12 CLA to be the main biologically active isomers, but they produce different physiological effects. 14) Cis-9, trans-11 CLA is an anticancer isomer, 15) and trans-10, cis-12 CLA is an antilipogenesis isomer.…”

mentioning

confidence: 99%

Production of Lean Beef Containing a High Content oftrans-10,cis-12Conjugated Linoleic Acid by Feeding a High-Temperature-Micro-Time-Treated Diet with Extruded Soybean

Lee

Lee³

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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“…Conversely, leptin was significantly positively associated with plasma phospholipid levels of alpha linoleic acid. Previous studies have shown reductions in leptin associated with conjugated linoleic acid supplementation in rats [63] and marine lipid (eicosapentaenoic acid and docosahexaenoic acid) consumption in humans [64].…”

Section: Accepted M Manuscriptmentioning

confidence: 96%

Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults

Gray¹,

Steyn²,

Davies³

et al. 2014

Nutrition Research

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Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats

Cited by 163 publications

References 44 publications

Influence of dietary conjugated linoleic acid (CLA) and tetradecylthioacetic acid (TTA) on growth, lipid composition and key enzymes of fatty acid oxidation in liver and muscle of Atlantic cod (Gadus morhua L.)

Influence of dietary conjugated linoleic acid (CLA) and tetradecylthioacetic acid (TTA) on growth, lipid composition and key enzymes of fatty acid oxidation in liver and muscle of Atlantic cod (Gadus morhua L.)

Production of Lean Beef Containing a High Content oftrans-10,cis-12Conjugated Linoleic Acid by Feeding a High-Temperature-Micro-Time-Treated Diet with Extruded Soybean

Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults

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