Effects of contamination on ion mobility detection after gas chromatography

Zhang

et al. 2023

AChrom

Gas chromatography-ion mobility spectrometry (GC-IMS) is an emerging analytical technique that has the advantages of fast response, high sensitivity, simple operation, and low cost. The combination of the fast speed and resolution of GC with the high sensitivity of IMS makes GC-IMS play an important role in the detection of food volatile substances. This paper focuses on the basic principles and future development trend, and the comparative analysis of the functions, similarities and differences of GC-IMS, GC-MS and electronic nose in the detection of common volatile compounds. A comprehensive introduction to the main application of GC-IMS in food volatile components: fingerprint identification of sample differences and detection of characteristic compounds. On the basis of perfecting the spectral library, GC-IMS will have broad development prospects in food authentication, origin identification, process optimization and product classification, especially in the analysis and identification of trace volatile food flavor substances.

Section: Gc-ims Technology Development Process and Status Quomentioning

confidence: 99%

Application of gas chromatography-ion mobility spectrometry in the analysis of food volatile components

Zhang

et al. 2023

AChrom

J. RES. NATL. BUR. STAN.

“…It was also found that the linear range of the detector could be extended by the use of a photoionization source [ 4 ]. As a GC detector the IMD has been compared to the FID and the ECD for contamination effects [ 5 ] and has been applied to the detection of 2,4-D in soils [ 6 ] and for the determination of barbiturates [ 7 ].…”

Section: Recent Accomplishmentsmentioning

confidence: 99%

Ion mobility spectrometry after chromatography - Accomplishments, goals, challenges

Hill¹,

Eatherton²

1988

Ion mobility spectrometry was first introduced to the analytical community in 1970 as an ultratrace organic technique under the name of plasma chromatography. Using highly sensitive ionization methods commonly employed in electron capture detectors coupled with an atmospheric pressure drift region to separate ions produced, it had the potential for widespread application in the separation and detection of trace quantities of organics. The ProblemsAs researchers began to investigate the method, a number of serious problems rapidly became evident: Competitive ion-molecule reactions which occurred in the ionization region of the detector limited its use as a quantitative instrument when complex mixtures were introduced into the spectrometer. Long residence times (sometimes measured in hours) in the spectrometer prevented practical application to a large number of samples.Often spectra for a single component were found to contain multiple ion peaks, hopelessly complicating true multicomponent interpretation. Recent AccomplishmentsWe designed and constructed an ion mobility spectrometer that was specifically suited for the detection of trace organics after separation by high resolution gas chromatography [1]. Using a unique unidirectional flow design, problems associated with long residence times in the spectrometer were eliminated. The high resolution gas chromatograph insured the purity of standards and enabled the in-425

“…There are a lot of activities worldwide associated with the adaptation of IMS to industrial and environmental applications [4][5][6][7][8][9][10][11][12][13]. New developments as the combination of IMS to pre-separation techniques such as gas-chromatographic columns [14][15][16][17][18][19][20][21][22][23] started. In recent years, the first applications of IMS came out with respect to applications in medical field [24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath

2009

Recently, ion mobility spectrometry (IMS) started to be used for direct breath analysis with respect to metabolic profiling, biomarker finding and gas trace analysis. The present review describes the basic operation of an ion mobility spectrometer including the ionization process, humidity effects and sampling procedures. To enhance the resolution, pre-separation by multi-capillary columns (MCCs) is discussed and examples for IMS chromatograms are presented. The focus is to review the analytical method IMS with respect to potential use for direct investigations of humid air in direct breath analysis but not on detailed discussion of results of specific medical application of MCC/IMS or on specific analytes found in exhaled air.