Effects of continuous UV-irradiation on the antioxidant activities of quercetin and rutin in solution in the presence of lecithin as the protective target

Cvetković, Dragan; Marković, Dejan; Cvetković, Dragana; Radovanović, Blaga

doi:10.2298/jsc101123089c

Cited by 28 publications

(39 citation statements)

References 30 publications

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“…[36][37][38] Thus, quercetin may provide protection against UV radiation either through absorption (preventive, inhibition mode) or scavenging activities ("chain-breaking", antioxidant mode). 47 The system studied in this work was more complex compared to the previous one 46 due to the presence of benzophenone. 29,40,41 In the latter case, quercetin (as well as other flavonoids) scavenges already created free radicals (such as lipid peroxy radicals, LOO • , or some ROS species present), mostly by the hydrogen-atom-transfer mechanism, shown in Eq.…”

Section: Introductionmentioning

confidence: 94%

“…However, flavonoids can also act as free radical scavengers to prevent oxidative skin damage [32][33][34][35] and their topical application has met with considerable interest. 45 In a recent publication, 46 the stabilities of two flavonoid components, quercetin and rutin, in solution toward UV-irradiation (from the three sub-ranges, UV-A, UV-B and UV-C), as well as their antioxidant activities in the presence of a lipoidal mixture (i.e., lecithin), as the "protection target", were compared. In the former case, the absorbed UV energy may be dissipated as heat 39 or converted into quercetin decomposition products, both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

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UV-induced change in quercetin antioxidant activity toward benzophenone initiated lipid peroxidation

Zvezdanovic¹,

Marković²,

Cvetkovic³

et al. 2012

J Serb Chem Soc

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The aim of this work is to estimate the degradation and change in antioxidant activity of quercetin in the presence of two different mixtures of phospholipids in methanol solution, under continuous UV-irradiation from three different sub-ranges (UV-A, UV-B and UV-C), in the presence and in the absence of selected UV-absorbing photosensitizer, benzophenone. Quercetin is employed to control lipid peroxidation process generated by UV-irradiation, by absorbing part of the UV-incident light, or/and by scavenging the involved, created free radicals. The results show that quercetin undergoes to irreversible destruction, highly dependent on UV-photons energy input, more expressed in the presence than in the absence of benzophenone. In the same time quercetin expresses suppression effect on lipid peroxidation processes in UV-irradiated phospholipid mixtures in both cases - absence or presence of benzophenone (more or less effective, respectively). In UV-C-irradiated mixtures, benzophenone photosensitizing function is significantly reduced due to its strong absorption in the same UV-C spectral range, therefore affecting less antioxidant activity of the remained quercetin

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

UV-induced change in quercetin antioxidant activity toward benzophenone initiated lipid peroxidation

Zvezdanovic¹,

Marković²,

Cvetkovic³

et al. 2012

J Serb Chem Soc

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“…Quercetin (QCT), a representative of a larger flavone family (3, 3' ,4' ,5,7-pentahydroxyflavone), is well known for its antioxidant properties (Cvetković et al 2011;Zvezdanović et al 2012). It is known that the flavonoid molecule localizes either in the hydrophobic region or in the polar region of the lipid bilayers, depending on hydrogen bonding of the hydroxyl groups (Košinova et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparative spectroscopic studies on liposomes containing chlorophyll a and chlorophyllide a

Milenković¹,

Barbinta-Patrascu²,

Baranga³

et al. 2013

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Abstract. Chlorophyll a (Chla) and chlorophyllide a (Chlida) -a derivative of Chla, have been incorporated in the lipid bilayers of two types of liposomes, small unilamellar vesicles (SUV) and multilamelar vesicles (MLV). The objective of the present work was to compare the spectral behaviour of Chla and Chlida incorporated in the lipid bilayers and their sensing behaviour at molecular level. The VIS absorption and fluorescence emission presented differences depending on the type of liposomes and inserted pigment, reflecting the different localization of porphyrin macrocycle in the lipid moieties. The temperature dependence of emission anisotropy and fluorescence intensity, for both Chla and Chlida incorporated in DPPC SUV, revealed the presence of different lipid phases. The degree of incorporation of quercetin (QCT) in liposome membrane was studied by using Chla and Chlida as molecular sensors. The fluorescence polarisation data and the fluorescence quenching process provided arguments for the insertion of the QCT at the interface lipid/water, in the vicinity of lipid polar heads and porphyrin macrocycle. The phytyl chain of Chla penetrating in the hydrophobic core of the lipid bilayers is responsible for the observed differences among Chla and Chlida in sensing the lipid phase transition and the fluorescence quenching process induced by QCT.

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“…However, in the case of olive and privet extracts, it is likely that their constituents, such as secoiridoids, are highly unstable compounds in the presence of the destructive effects of UV radiation (Bruneton, 1999). Additionally, flavonoids are also distinguished by a greater sensitivity to UV radiation (Cvetković et al, 2011). The antioxidant activity of olive leaf extracts has never been investigated in UV-irradiated fibroblasts.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Czerwińska

Duszak

Parzonko

et al. 2016

Acta Biologica Cracoviensia S. Botanica

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Plants belonging to the family Oleaceae have been traditionally used in treatment of various inflammatory skin disorders. One of the most well-known species is Olea europaea L. (olive), cultivated in the Mediterranean countries. Another species is Ligustrum vulgare L. (common privet), occurring particularly in Northern Europe and Asia. The aim of the study was a comparison of the composition of aqueous and ethanolic extracts from leaves of O. europaea and L. vulgare (HPLC-DAD-MS), and determination of the total content of phenolics and flavonoids, as well as the content of the major compound, oleuropein. Secondly, we aimed to study the protective effect of extracts on reactive oxygen species (ROS) production by human fibroblast cells (NHDF), cell viability (MTT assay), and apoptosis rate (Annexin V/propidium iodide staining) after UVA-irradiation. The phytochemical analysis allowed us to identify compounds belonging to the groups of flavonoids, phenylpropanoids and secoiridoids in the extracts. The compounds from the group of lignans (olivil) were identified as being unique to O. europaea extracts. Echinacoside, ligustroflavone and ligustaloside A were identified in L. vulgare extracts in contrast to olive preparations. It was established that the aqueous and ethanolic extracts from leaves of both species, except the privet aqueous extract at a concentration of 5 μg/ml, did not show any significant inhibition of ROS production after UVA-irradiation in the model of NHDF cell line. The aqueous extracts of both species at concentrations of 5 and 25 μg/ml had a protective effect on the viability of UVA-treated cells in contrast to the ethanolic extract. In conclusion, no significant difference in the activity of olive and privet leaf extracts has been observed, which suggests that both plant materials' extracts, particularly aqueous ones, are effective herbal medicines and photoprotectors, which -to some extent -confirms the use of their preparations in skin disorders.

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Effects of continuous UV-irradiation on the antioxidant activities of quercetin and rutin in solution in the presence of lecithin as the protective target

Cited by 28 publications

References 30 publications

UV-induced change in quercetin antioxidant activity toward benzophenone initiated lipid peroxidation

UV-induced change in quercetin antioxidant activity toward benzophenone initiated lipid peroxidation

Comparative spectroscopic studies on liposomes containing chlorophyll a and chlorophyllide a

Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

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