Effects of contraceptive agents on the biochemical and protein composition of human endometrium

Umapathysivam, Kandiah; Jones, Warren R.

doi:10.1016/0010-7824(80)90027-x

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…However, this includes all the extracellular protein matrix and may not give a true reflection of cellular enzyme activity. Similarly, tissue weight is an unreliable parameter of cellular activity (Umapathysivam and Jones, 1980). When enzyme activity is expressed in terms of DNA content, this reflects enzyme activity per cell which is a better reflection of activity of a substance which is a cellular product (Cornillie et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Endometrial lysosomal enzyme activity in normal cycling endometrium

Wang

Cornillie²,

Barsamian³

et al. 1999

Molecular Human Reproduction

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The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-beta-D-glucosaminidase was relatively high, whilst that of alpha-L-fucosidase and alpha-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle.

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Section: Discussionmentioning

confidence: 99%

Endometrial lysosomal enzyme activity in normal cycling endometrium

Wang

Cornillie²,

Barsamian³

et al. 1999

Molecular Human Reproduction

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show abstract

“…1,10,12,20,21 These effects have been presumed to render the endometrium relatively inhospitable to implantation or to the maintenance of the preembryo or embryo prior to clinically recognized pregnancy by producing a predecidual or decidualized endometrial bed with diminished thickness and with widely spaced, exhausted, and atrophied glands; by altering the cellular structure of the endometrium, leading to the production of areas of edema alternating with areas of dense cellularity 18,20,21 ; and by altering the biochemical and protein composition of the endometrium. 47 Although these changes are consistently seen in women taking OCs, there is currently no direct evidence to link these changes to preembryo or embryo loss in women taking OCs. However, this hypothesized postfertilization effect seems to be so well accepted that in many medical articles and textbooks it has been explicitly listed as the third mechanism of OCs (after suppressing ovulation and prefertilization effects).…”

Section: Endometrial Changes That May Affect Endometrial Receptivitymentioning

confidence: 99%

Postfertilization Effects of Oral Contraceptives and Their Relationship to Informed Consent

Larimore¹

2000

Archives of Family Medicine

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Postfertilization Effects of Oral Contraceptives and Their Relationship to Informed Consent

Larimore

Stanford

2000

Archives of Family Medicine

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The primary mechanism of oral contraceptives is to inhibit ovulation, but this mechanism is not always operative. When breakthrough ovulation occurs, then secondary mechanisms operate to prevent clinically recognized pregnancy. These secondary mechanisms may occur either before or after fertilization. Postfertilization effects would be problematic for some patients, who may desire information about this possibility. This article evaluates the available evidence for the postfertilization effects of oral contraceptives and concludes that good evidence exists to support the hypothesis that the effectiveness of oral contraceptives depends to some degree on postfertilization effects. However, there are insufficient data to quantitate the relative contribution of postfertilization effects. Despite the lack of quantitative data, the principles of informed consent suggest that patients who may object to any postfertilization loss should be made aware of this information so that they can give fully informed consent for the use of oral contraceptives.

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Effects of contraceptive agents on the biochemical and protein composition of human endometrium

Cited by 8 publications

References 16 publications

Endometrial lysosomal enzyme activity in normal cycling endometrium

Endometrial lysosomal enzyme activity in normal cycling endometrium

Postfertilization Effects of Oral Contraceptives and Their Relationship to Informed Consent

Postfertilization Effects of Oral Contraceptives and Their Relationship to Informed Consent

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