Effects of coordination mode of 2-mercaptothiazoline on reactivity of Au(I) compounds with thiols and sulfur-containing proteins

X-ray Absorption Spectroscopy Combined with Time-Dependent Density Functional Theory Elucidates Differential Substitution Pathways of Au(I) and Au(III) with Zinc Fingers

“…The electronic structure of Au− CN − compounds is of interest due to the formation of {(NC) y Au x -NCp7} (x,y ≤ 3) in the reaction of Au(I)mercaptothiazoline compounds with the C-terminal NCp7. 62 The electronic structure is also of interest in the broader context of the effect of CN − on biodistribution of gold and the observation of [Au(CN) 2 ] − as a common metabolite of Au(I) drugs. 63,64 Au(III) compounds show the highest white line peaks in the series investigated, as a consequence of empty d orbitals promoting the allowed 2p 3/2 → 5d transitions in the L 3edge XAS, again having a simplistic atomic orbital picture in mind.…”

“…Furthermore, the Ph 3 P ligand is a weaker σ donor than Et 3 P. The intense white lines of compounds 7 and 8 , unusual for the Au­(I) case, reveal a substantial amount of unoccupied d-orbital character in those complexes, rationalized by the interaction of Au­(I) d orbitals with π* orbitals from CN – . The electronic structure of Au–CN – compounds is of interest due to the formation of {(NC) y Au x -NCp7} ( x , y ≤ 3) in the reaction of Au­(I)-mercaptothiazoline compounds with the C-terminal NCp7 . The electronic structure is also of interest in the broader context of the effect of CN – on biodistribution of gold and the observation of [Au­(CN) 2 ] − as a common metabolite of Au­(I) drugs. , Au­(III) compounds show the highest white line peaks in the series investigated, as a consequence of empty d orbitals promoting the allowed 2p 3/2 → 5d transitions in the L 3 -edge XAS, again having a simplistic atomic orbital picture in mind.…”

A Cytotoxic Bis(1,2,3‐triazol‐5‐ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation

“…The result is a bend in the DNA and a shortening of the effective length of the helix. The same effect is induced by the covalent binder cisplatin [6,10] . The significant non‐linear increase in the viscosity of ctDNA induced by 4 b is unique, reflecting neither the behavior of a classical intercalator nor a conventional partial intercalator.…”

“…The wide range of coordination numbers, geometries, ligands, and redox states available for metal complexes provide chemists with an impressive array of molecular tools to target one, or several, biological macromolecules. A topical objective is to design metallodrugs for multi‐faceted chemotherapeutic approaches [1–10] . Gold complexes, irrespective of their oxidation state, have emerged as effective anticancer agents due to their ability to target DNA and/or several intracellular proteins [11–25] .…”

Antileishmanial and Anti‐Chikungunya Activity of Cu(I)‐N‐Heterocyclic Carbenes

“…This value is within the range considered ideal, high enough for transport and distribution of a significant amount in the body, but at the same time low enough that the compound can be released once it reaches its target. In complexes ( 5 ) and ( 6 ), n is close to 1, thus evidencing that only one molecule of these copper complexes is inserted into the protein frames [54,55,58] …”