Air-core photonic crystal waveguides with cylindrically periodic index variations are first proposed, thereby making low-index cores. The proposed aircore cylindrical photonic crystal waveguides (APCWs) possess numerous novel properties, including large or small effective areas. Based on two computational analyses of the finite-difference time-domain and finite difference method for accurate and cross-verified results, sizing the central core provides a decent way to control the effective area. Compared to the conventional step-index or dispersionshifted optical fibers with effective areas of 50-100 m 2 in the 1.5-m wavelength range, increased effective area results are well obtained for the designed APCW with r1 = 2 m and seven layers as 199.4 m 2 at the operation wavelength of 1.3 m and 201.2 m 2 at 1.55 m. It is also confirmed that the chromatic dispersion is very small, manageable, and moreover close to zero around the operating wavelength of 1.2 m. Additionally, depending on the desired applications, investigations for reasonable and efficient designing of the APCWs with respect to superior effective core areas can lead to useful improvements related to lightwave communications.