1996
DOI: 10.1016/0006-8993(96)00289-2
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Effects of corticosteroid synthesis inhibitors on the sensitization of reward by food restriction

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1996
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Cited by 20 publications
(4 citation statements)
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“…Prolonged negative energy balance results in increased expression of NPY in the hypothalamus; however, administration of NPY does not alter LH self-stimulation [8]. Although FR can be viewed as a stressor, acute modulation of corticosterone availability does not reverse the capacity of FR to sensitize LH self-stimulation [12]. These studies collectively suggest that FR may act through as yet unidentified feeding relevant system(s) to modulate psychostimulant reactivity.…”
Section: Introductionmentioning
confidence: 71%
“…Prolonged negative energy balance results in increased expression of NPY in the hypothalamus; however, administration of NPY does not alter LH self-stimulation [8]. Although FR can be viewed as a stressor, acute modulation of corticosterone availability does not reverse the capacity of FR to sensitize LH self-stimulation [12]. These studies collectively suggest that FR may act through as yet unidentified feeding relevant system(s) to modulate psychostimulant reactivity.…”
Section: Introductionmentioning
confidence: 71%
“…Therefore, a heightened physiological stress response may not always be necessary for the expression of stress-related behaviors. Abrahamsen and Carr (1996) demonstrated that in a lateral hypothalamus self-stimulation procedure, the sensitization of the rewarding effects of the stimulation by food restriction is unaltered following a treatment with a corticosterone synthesis inhibitor or an acute feeding-induced decrease in plasma corticosterone (Abrahamsen et al, 1995). The aforementioned studies argue against a modulatory role for corticosterone in rewarding-seeking.…”
Section: Discussionmentioning
confidence: 99%
“…The increased general mobility of the DER rats observed on the first day could reflect stress-relieving effects following the removal of the feeder. On the other hand, the higher locomotion of DER animals on later days as well as the increased rearing activity could result from a reward oversensitization due to food restriction (Abrahamsen and Carr, 1996;Tapp et al, 2020). Notably, locomotor sensitization has been proposed as a predictor of drug addiction (Robinson and Berridge, 2008), and locomotion and place preference sensitization are both considered indicators of drug abuse induced by early life stress (Levis et al, 2022), as early life adversity has been associated with increased risk for substance abuse in both humans (Enoch, 2011;Varese et al, 2012) and rodents (Levis et al, 2022).…”
Section: Discussionmentioning
confidence: 99%