Effects of Corticosterone Intake as Stress-Alternative Hormone on Broiler Chickens: Performance and Blood Parameters

Vahdatpour, Tohid; Adl, K Nazer; Nezhad, Y Ebrahim; Maheri-Sis, Naser; Riyazi, Seyyed Reza; Vahdatpour, Sina

doi:10.3923/ajava.2009.16.21

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…It has been previously reported that various stressors change weights of lymphoid organs (Puvadolpirod & Thaxton 2000;Post et al 2003;Vahdatpour et al 2009;Quinteiro-Filho et al 2010). Our results clearly showed that environmental enrichment did not affect body and organ weights, but transport stress had an impact on liver, spleen and bursa of Fabricius weights.…”

Section: Discussionsupporting

confidence: 68%

“…Our results clearly showed that environmental enrichment did not affect body and organ weights, but transport stress had an impact on liver, spleen and bursa of Fabricius weights. It has been previously reported that various stressors change weights of lymphoid organs (Puvadolpirod & Thaxton 2000;Post et al 2003;Vahdatpour et al 2009;Quinteiro-Filho et al 2010). Therefore, the effects of transport stress on the abovementioned organs could be expected.…”

Section: Discussionmentioning

confidence: 94%

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The effects of environmental enrichment and transport stress on the weights of lymphoid organs, cell‐mediated immune response, heterophil functions and antibody production in laying hens

Matur

Akyazı

Eraslan

et al. 2015

Animal Science Journal

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The effects of environmental enrichment and transport stress on the immune system were investigated in laying hens. A total of 48 1-day-old chickens were used, half of the chickens were reared in conventional cages (RCC) and the rest in enriched cages (REC). Transport stress was applied in the 17th week. Liver weight decreased, spleen and bursa of Fabricius weights, white blood cell count, CD4+ and CD8+ cell proportions increased due to the transport. Environmental enrichment significantly increased antibody production and tended to increase monocyte percentage and CD8+ cell proportion. The effect of transport on, heterophil (H) and lymphocyte (L) percentages was not significant in RCC chickens. While heterophil percentage and H:L ratio increased, lymphocyte percentage decreased in REC chickens subjected to transport. Transport stress increased heterophil functions both in REC and RCC chickens, but the increase was higher in REC hens than in RCC hens. In conclusion, although environmental enrichment did not neutralize the effect of transport on lymphoid organs, it activated the non-specific immune system, cellular and the humoral branches of the specific immune system by increasing heterophil functions, CD8+ cells and antibody production, respectively. Therefore, environmental enrichment suggested for improving animal welfare may also be beneficial to improve the immune system of birds exposed to stress.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 94%

The effects of environmental enrichment and transport stress on the weights of lymphoid organs, cell‐mediated immune response, heterophil functions and antibody production in laying hens

Matur

Akyazı

Eraslan

et al. 2015

Animal Science Journal

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“…Finally, we also examined organ masses, as glucocorticoids may have both direct and indirect effects on organ size (Dong et al 2007;Shini et al 2009). High CORT values may be negatively associated with masses of metabolically or immunologically active organs (e.g., heart, brain, spleen, musculoskeletal system), potentially to compensate for increased metabolic demands typically seen as a result of activation of the hypothalamic-pituitary-adrenal (HPA) axis (Elliott et al 2003;Shini et al 2009;Vahdatpour et al 2009). Moreover, organ sizes (particularly those of metabolically active organs) may correlate with the upper and lower limits of aerobic metabolism (Konarzewski and Diamond 1995;Javed et al 2010;Kolb et al 2010;Ksiazek and Konarzewski 2012) and voluntary exercise .…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoids, Aerobic Physiology, and Locomotor Behavior in California Mice

Dlugosz

Harris

Saltzman

et al. 2012

Physiological and Biochemical Zoology

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The glucocorticoid hormones corticosterone (CORT) and cortisol influence numerous physiological, morphological, and behavioral functions. However, few studies have addressed possible relationships between individual differences in glucocorticoid concentrations and whole-animal performance or metabolism. Because CORT is important in glucose regulation and energy metabolism and can influence activity levels, we hypothesized that individual variation in baseline circulating CORT levels would correlate with individual differences in energy expenditure (routine and maximal), aerobic physiology, voluntary exercise on wheels, and organ masses. We tested this hypothesis in the California mouse (Peromyscus californicus). We collected data from 54 adult, colony-bred mice on baseline CORT levels (measured near both the circadian peak and the circadian trough), voluntary wheel running and its energetic costs, maximal oxygen consumption during forced treadmill exercise ([Formula: see text]), basal metabolic rate, and relative organ masses. We found surprisingly few statistically significant relationships among CORT, energy metabolism, behavior, and organ masses, and these relationships appeared to differ between males and females. These findings suggest that individual differences in baseline CORT levels are not an important determinant of voluntary activity levels or aerobic performance in California mice.

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“…21 Dex treatment is thought to reproduce the effects of high levels of corticosterone, thus mimicking stress associated signaling pathways. 24 The higher the serum corticosterone level, the more obvious the immunosuppression. 23 In this study, the physiological indexes such as corticosterone, glucose, and triglyceride in peripheral blood of chickens, serum CD3 + , CD4 + , IgG, TNF-α, IL-1β, IL-6, and relative lymphoid organ weights were detected after the Dex treatment.…”

Section: Discussionmentioning

confidence: 99%

Transcriptom analysis revealed regulation of dexamethasone induced microRNAs in chicken thymus

Zhou

Tian

Zhang

et al. 2018

J of Cellular Biochemistry

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Stress‐induced immunosuppression is one of the serious threats to the poultry industry, especially obvious for young chicken. However, the molecular mechanism of stress‐induced immunosuppression has not been clear in chicken. Here, we established an immunosuppression model of 7‐day‐old chickens with injecting dexamethasone (Dex) to analyze the molecular regulation in the chicken thymus. The microRNAs (miRNAs) transcripts profiles of thymuses from the model and control group were identified by the Solexa sequencing technology. The results showed 121 significantly differently expressed (SDE) miRNAs, including 119 known and two novel miRNAs (novel‐58 and novel‐350). A total of 391 target genes of the SDE miRNAs were predicted and annotated. We verified the potential negative correlation between gga‐miR‐103‐3p and TGM2 by quantitative real‐time polymerase chain reaction (qRT‐PCR), as well as between novel‐350 and PCBD2, and the results were positive. Gene ontology (GO) enrichment analysis showed that there was 298 significant enrichment GO terms, in which 31 were related to immune or stress, such as lymphocyte apoptotic process and response to stress. KEGG pathway analysis suggested that the SDE miRNAs were involved in autophagy regulation, cytokine‐cytokine receptor interaction, Toll‐like receptor signaling pathway, Jak‐STAT signaling pathway, and so on (although not significantly enriched). In these immune signaling pathways, the SDE miRNAs (such as gga‐miR‐2954, gga‐miR‐146b‐3p, gga‐miR‐106‐3p, and gga‐miR‐214) and the predicted target genes (such as IL11Ra, CSF3R, IFNGR1, CNTF, and MAP2K2) might affect the thymus immune function of chicken. The above results would provide a basis for uncovering the molecular regulation mechanism of immunosuppression in poultry.

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Effects of Corticosterone Intake as Stress-Alternative Hormone on Broiler Chickens: Performance and Blood Parameters

Cited by 21 publications

References 19 publications

The effects of environmental enrichment and transport stress on the weights of lymphoid organs, cell‐mediated immune response, heterophil functions and antibody production in laying hens

The effects of environmental enrichment and transport stress on the weights of lymphoid organs, cell‐mediated immune response, heterophil functions and antibody production in laying hens

Glucocorticoids, Aerobic Physiology, and Locomotor Behavior in California Mice

Transcriptom analysis revealed regulation of dexamethasone induced microRNAs in chicken thymus

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